Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma
Background: Evasion of apoptosis is an essential alteration for cellular genetic mutation. Survivin is a member of inhibitor of apoptosis protein (IAP) family. Under normal conditions, Survivin is expressed in embryonic and fetal tissues and markedly diminished in mature, differentiated adult tissue...
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| Format: | Article |
| Language: | English |
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West Asia Organization for Cancer Prevention
2021-08-01
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| Series: | Asian Pacific Journal of Cancer Biology |
| Subjects: | |
| Online Access: | http://www.waocp.com/journal/index.php/apjcb/article/view/702 |
| _version_ | 1797341007265660928 |
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| author | Maisa Hashem Mohammed Nagwa Abd El-Sadek Ahmed |
| author_facet | Maisa Hashem Mohammed Nagwa Abd El-Sadek Ahmed |
| author_sort | Maisa Hashem Mohammed |
| collection | DOAJ |
| description | Background: Evasion of apoptosis is an essential alteration for cellular genetic mutation. Survivin is a member of inhibitor of apoptosis protein (IAP) family. Under normal conditions, Survivin is expressed in embryonic and fetal tissues and markedly diminished in mature, differentiated adult tissues. Survivin was found to be re-expressed in multiple solid and hematological human malignant neoplasms. The purpose of this study was to evaluate the expression of Survivin in renal cell carcinoma (RCC), and to find statistically significant associations between Survivin and the tested Clinicopathological parameters.
Methods: 39 patients with RCCs who underwent nephrectomy were included in the study. From each RCC specimen, two tissue sections were obtained; one was stained by H&E stain to determine both RCC phenotype and Fuhrman’s nuclear grades. The second tissue section was immunohistochemically stained by anti-human Survivin antibody.
Results: The study revealed statistically significant associations between Survivin expression in RCC specimens and RCC histological types (p =0.002), high tumor grade (p< 0.001) and advanced tumor stage (p< 0.001).
Conclusion: The study revealed that Survivin is positively correlated to poorly differentiated RCCs with high Fuhrman’s nuclear grade and advanced tumor stage. |
| first_indexed | 2024-03-08T10:11:39Z |
| format | Article |
| id | doaj.art-4b6dcea361dc44f09925a7a9fa13df7b |
| institution | Directory Open Access Journal |
| issn | 2538-4635 |
| language | English |
| last_indexed | 2024-03-08T10:11:39Z |
| publishDate | 2021-08-01 |
| publisher | West Asia Organization for Cancer Prevention |
| record_format | Article |
| series | Asian Pacific Journal of Cancer Biology |
| spelling | doaj.art-4b6dcea361dc44f09925a7a9fa13df7b2024-01-29T07:19:44ZengWest Asia Organization for Cancer PreventionAsian Pacific Journal of Cancer Biology2538-46352021-08-016320120510.31557/apjcb.2021.6.3.201-205702Significance of Immunohistochemical Expression of Survivin in Renal Cell CarcinomaMaisa Hashem Mohammed0Nagwa Abd El-Sadek Ahmed1Department of Pathology, Faculty of Medicine, Sohage University, Egypt.Department of Pathology, Faculty of Medicine, Sohag University, Sohag, EgyptBackground: Evasion of apoptosis is an essential alteration for cellular genetic mutation. Survivin is a member of inhibitor of apoptosis protein (IAP) family. Under normal conditions, Survivin is expressed in embryonic and fetal tissues and markedly diminished in mature, differentiated adult tissues. Survivin was found to be re-expressed in multiple solid and hematological human malignant neoplasms. The purpose of this study was to evaluate the expression of Survivin in renal cell carcinoma (RCC), and to find statistically significant associations between Survivin and the tested Clinicopathological parameters. Methods: 39 patients with RCCs who underwent nephrectomy were included in the study. From each RCC specimen, two tissue sections were obtained; one was stained by H&E stain to determine both RCC phenotype and Fuhrman’s nuclear grades. The second tissue section was immunohistochemically stained by anti-human Survivin antibody. Results: The study revealed statistically significant associations between Survivin expression in RCC specimens and RCC histological types (p =0.002), high tumor grade (p< 0.001) and advanced tumor stage (p< 0.001). Conclusion: The study revealed that Survivin is positively correlated to poorly differentiated RCCs with high Fuhrman’s nuclear grade and advanced tumor stage.http://www.waocp.com/journal/index.php/apjcb/article/view/702rcc, survivin, apoptosis, ccrcc, sarcomatoid rcc. |
| spellingShingle | Maisa Hashem Mohammed Nagwa Abd El-Sadek Ahmed Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma Asian Pacific Journal of Cancer Biology rcc, survivin, apoptosis, ccrcc, sarcomatoid rcc. |
| title | Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma |
| title_full | Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma |
| title_fullStr | Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma |
| title_full_unstemmed | Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma |
| title_short | Significance of Immunohistochemical Expression of Survivin in Renal Cell Carcinoma |
| title_sort | significance of immunohistochemical expression of survivin in renal cell carcinoma |
| topic | rcc, survivin, apoptosis, ccrcc, sarcomatoid rcc. |
| url | http://www.waocp.com/journal/index.php/apjcb/article/view/702 |
| work_keys_str_mv | AT maisahashemmohammed significanceofimmunohistochemicalexpressionofsurvivininrenalcellcarcinoma AT nagwaabdelsadekahmed significanceofimmunohistochemicalexpressionofsurvivininrenalcellcarcinoma |