In vitro release and in vivo growth-promoting effects of coated cysteamine in broilers
ABSTRACT: The purpose of this study was to investigate the effects of coating technology on the cysteamine (CSH) release in the digestive tract and the growth-promoting effect of enteric-coating CSH in broilers. First, using the self-developed computer-controlled simulated digestion system to mimic...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-04-01
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| Series: | Poultry Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0032579123000019 |
| _version_ | 1797854324099907584 |
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| author | Youyou Liu Biyue Zhao Yujing Feng Hu Zhang Qianyun Zhang Jia Hou Yuming Wang Renna Sa Feng Zhao Jingjing Xie |
| author_facet | Youyou Liu Biyue Zhao Yujing Feng Hu Zhang Qianyun Zhang Jia Hou Yuming Wang Renna Sa Feng Zhao Jingjing Xie |
| author_sort | Youyou Liu |
| collection | DOAJ |
| description | ABSTRACT: The purpose of this study was to investigate the effects of coating technology on the cysteamine (CSH) release in the digestive tract and the growth-promoting effect of enteric-coating CSH in broilers. First, using the self-developed computer-controlled simulated digestion system to mimic the digestion process in vitro, the release of 2 coated CSH (CSH-I and CSH-Ⅱ) were studied. The results showed that less than 10% of CSH-I was released after gastric digestion and 52.35% of CSH-I was released with additional 4 h of small intestinal digestion. In contrast, 83.62% of CSH-Ⅱ was released during the gastric digestion. In order to verify the growth-promoting effects of CSH-I, a feeding trial was conducted in a completely randomized block arrangement with 3 treatments in 6 blocks, 5 chickens per replicate. Broilers were fed with corn-soybean meal diet either supplemented with 0 (CON), 200 mg/kg uncoated CSH (CSH) or 200 mg/kg CSH-I from d 7 to 42, respectively. Body weight and FI was recorded at d 21 and 42. Excreta were collected from d 39 to d 42 to determine the total tract retention (TTR) of dietary nutrients. In comparisons with controls, birds fed with CSH-I had greater BW, ADG, and ADFI and increased TTR of DM, gross energy (GE), NDF and hemicellulose (P < 0.05). In addition, duodenal villi height and surface area were also greater in those CSH-I-fed birds. In contrast, the growth performance of birds fed with uncoated CSH did not significantly differ from controls. Although the TTR of DM and GE was higher in birds fed with CSH than controls, no differences in small intestine morphology were noted. Thus, the type I coating (CSH-I) could be good enteric-coating technology to increase CSH release in the duodenum, improve digestion and duodenal morphology, and therefore growth performance in broilers. |
| first_indexed | 2024-04-09T20:05:14Z |
| format | Article |
| id | doaj.art-4b6e53d4fb3742d69a8292a38cd2d2b0 |
| institution | Directory Open Access Journal |
| issn | 0032-5791 |
| language | English |
| last_indexed | 2024-04-09T20:05:14Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Poultry Science |
| spelling | doaj.art-4b6e53d4fb3742d69a8292a38cd2d2b02023-04-02T06:10:42ZengElsevierPoultry Science0032-57912023-04-011024102475In vitro release and in vivo growth-promoting effects of coated cysteamine in broilersYouyou Liu0Biyue Zhao1Yujing Feng2Hu Zhang3Qianyun Zhang4Jia Hou5Yuming Wang6Renna Sa7Feng Zhao8Jingjing Xie9State Key laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China; Animal Science Department, Hebei Normal University of Science & Technology, Qinhuangdao, ChinaState Key laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaProvincial Key Agricultural Enterprise Research Institute of Encapsulated Feed Additive, King Techina Technology Co., Ltd., Hangzhou, ChinaProvincial Key Agricultural Enterprise Research Institute of Encapsulated Feed Additive, King Techina Technology Co., Ltd., Hangzhou, ChinaState Key laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, ChinaState Key laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China; Corresponding author:ABSTRACT: The purpose of this study was to investigate the effects of coating technology on the cysteamine (CSH) release in the digestive tract and the growth-promoting effect of enteric-coating CSH in broilers. First, using the self-developed computer-controlled simulated digestion system to mimic the digestion process in vitro, the release of 2 coated CSH (CSH-I and CSH-Ⅱ) were studied. The results showed that less than 10% of CSH-I was released after gastric digestion and 52.35% of CSH-I was released with additional 4 h of small intestinal digestion. In contrast, 83.62% of CSH-Ⅱ was released during the gastric digestion. In order to verify the growth-promoting effects of CSH-I, a feeding trial was conducted in a completely randomized block arrangement with 3 treatments in 6 blocks, 5 chickens per replicate. Broilers were fed with corn-soybean meal diet either supplemented with 0 (CON), 200 mg/kg uncoated CSH (CSH) or 200 mg/kg CSH-I from d 7 to 42, respectively. Body weight and FI was recorded at d 21 and 42. Excreta were collected from d 39 to d 42 to determine the total tract retention (TTR) of dietary nutrients. In comparisons with controls, birds fed with CSH-I had greater BW, ADG, and ADFI and increased TTR of DM, gross energy (GE), NDF and hemicellulose (P < 0.05). In addition, duodenal villi height and surface area were also greater in those CSH-I-fed birds. In contrast, the growth performance of birds fed with uncoated CSH did not significantly differ from controls. Although the TTR of DM and GE was higher in birds fed with CSH than controls, no differences in small intestine morphology were noted. Thus, the type I coating (CSH-I) could be good enteric-coating technology to increase CSH release in the duodenum, improve digestion and duodenal morphology, and therefore growth performance in broilers.http://www.sciencedirect.com/science/article/pii/S0032579123000019coated cysteaminein vitro digestionrelease kineticsnutrient's retentionintestinal morphology |
| spellingShingle | Youyou Liu Biyue Zhao Yujing Feng Hu Zhang Qianyun Zhang Jia Hou Yuming Wang Renna Sa Feng Zhao Jingjing Xie In vitro release and in vivo growth-promoting effects of coated cysteamine in broilers Poultry Science coated cysteamine in vitro digestion release kinetics nutrient's retention intestinal morphology |
| title | In vitro release and in vivo growth-promoting effects of coated cysteamine in broilers |
| title_full | In vitro release and in vivo growth-promoting effects of coated cysteamine in broilers |
| title_fullStr | In vitro release and in vivo growth-promoting effects of coated cysteamine in broilers |
| title_full_unstemmed | In vitro release and in vivo growth-promoting effects of coated cysteamine in broilers |
| title_short | In vitro release and in vivo growth-promoting effects of coated cysteamine in broilers |
| title_sort | in vitro release and in vivo growth promoting effects of coated cysteamine in broilers |
| topic | coated cysteamine in vitro digestion release kinetics nutrient's retention intestinal morphology |
| url | http://www.sciencedirect.com/science/article/pii/S0032579123000019 |
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