Putative Familial Transmissible Bacteria of Various Body Niches Link with Home Environment and Children’s Immune Health
ABSTRACT Owing to their significant impact on children’s long-term health, familial factors in the microbiomes of children have attracted increasing attention. However, the mechanism underlying microbiome transmission across generations remains unclear. A significantly lower alpha diversity was obse...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2021-12-01
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| Series: | Microbiology Spectrum |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/Spectrum.00872-21 |
| _version_ | 1828126749425139712 |
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| author | Lu Zhao Wanning Chen Yongsheng Ge Xin Lv Ying Wang Han Yu Yi Liu Dingfeng Wu Na Jiao Yuanqi Wu Daqing Lv Guoqing Zhang Fuzhong Xue Xiaohong Xu Zhongtao Gai Ruixin Zhu Lei Zhang Guoping Zhao |
| author_facet | Lu Zhao Wanning Chen Yongsheng Ge Xin Lv Ying Wang Han Yu Yi Liu Dingfeng Wu Na Jiao Yuanqi Wu Daqing Lv Guoqing Zhang Fuzhong Xue Xiaohong Xu Zhongtao Gai Ruixin Zhu Lei Zhang Guoping Zhao |
| author_sort | Lu Zhao |
| collection | DOAJ |
| description | ABSTRACT Owing to their significant impact on children’s long-term health, familial factors in the microbiomes of children have attracted increasing attention. However, the mechanism underlying microbiome transmission across generations remains unclear. A significantly lower alpha diversity was observed in the gut flora of children than in the gut flora of parents and grandparents; the alpha diversity of oral and skin microbiota was relatively higher in children than in their predecessors. Gut, oral, and skin microbiome was more similar between family members than between unrelated individuals. Meanwhile, 55.05%, 61.09%, and 76.73% of amplicon sequence variants (ASVs) in children’s gut, oral, and skin microbiomes, respectively, were transmitted from all family members. Among these, the most transmissible ASVs belonged to Methylophilaceae, Solimonadaceae, Neisseriaceae, and Burkholderiaceae, which were defined as “putative familial transmissible bacteria.” Furthermore, we found that the time spent with parents/grandparents and children’s dietary preferences were important factors that influenced the proportion of the transmissible microbiome. Moreover, the majority of transmissible ASVs (85.06%), especially those of Ruminococcaceae and Lachnospiraceae, were significantly associated with the immune indices, such as CD3+, CD4+, CD8+, IgG, and IgA. IMPORTANCE Our study revealed that the children’s microbiota was partially transmitted from their family members and specific putative transmissible ASVs were associated with the immune system of children. These findings suggest that home life plays a key role in the shaping of young children’s microbiomes and has long-term health benefits. |
| first_indexed | 2024-04-11T15:40:15Z |
| format | Article |
| id | doaj.art-4b6f2aca53084423a80c8f1b44f31006 |
| institution | Directory Open Access Journal |
| issn | 2165-0497 |
| language | English |
| last_indexed | 2024-04-11T15:40:15Z |
| publishDate | 2021-12-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | Microbiology Spectrum |
| spelling | doaj.art-4b6f2aca53084423a80c8f1b44f310062022-12-22T04:15:51ZengAmerican Society for MicrobiologyMicrobiology Spectrum2165-04972021-12-019310.1128/Spectrum.00872-21Putative Familial Transmissible Bacteria of Various Body Niches Link with Home Environment and Children’s Immune HealthLu Zhao0Wanning Chen1Yongsheng Ge2Xin Lv3Ying Wang4Han Yu5Yi Liu6Dingfeng Wu7Na Jiao8Yuanqi Wu9Daqing Lv10Guoqing Zhang11Fuzhong Xue12Xiaohong Xu13Zhongtao Gai14Ruixin Zhu15Lei Zhang16Guoping Zhao17Shandong Children’s Microbiome Center, Pediatric Research Institute, Qilu Children’s Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of ChinaDepartment of Gastroenterology, The Shanghai Tenth People’s Hospital, Department of Bioinformatics, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of ChinaShandong Children’s Microbiome Center, Pediatric Research Institute, Qilu Children’s Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of ChinaLaboratory Medicine, Qilu Children's Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of ChinaShandong Children’s Microbiome Center, Pediatric Research Institute, Qilu Children’s Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of ChinaShandong Children’s Microbiome Center, Pediatric Research Institute, Qilu Children’s Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of ChinaShandong Children’s Microbiome Center, Pediatric Research Institute, Qilu Children’s Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of ChinaDepartment of Gastroenterology, The Shanghai Tenth People’s Hospital, Department of Bioinformatics, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of ChinaGuangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Department of Colorectal Surgery, the Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, People’s Republic of ChinaDepartment of Gastroenterology, The Shanghai Tenth People’s Hospital, Department of Bioinformatics, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of ChinaCAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of ChinaCAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of ChinaDepartment of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of ChinaResearch Institute, GloriousMed Clinical Laboratory Co., Ltd., Shanghai, People’s Republic of ChinaShandong Children’s Microbiome Center, Pediatric Research Institute, Qilu Children’s Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of ChinaDepartment of Gastroenterology, The Shanghai Tenth People’s Hospital, Department of Bioinformatics, School of Life Sciences and Technology, Tongji University, Shanghai, People’s Republic of ChinaShandong Children’s Microbiome Center, Pediatric Research Institute, Qilu Children’s Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of ChinaCAS Key Laboratory of Computational Biology, Bio-Med Big Data Center, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of ChinaABSTRACT Owing to their significant impact on children’s long-term health, familial factors in the microbiomes of children have attracted increasing attention. However, the mechanism underlying microbiome transmission across generations remains unclear. A significantly lower alpha diversity was observed in the gut flora of children than in the gut flora of parents and grandparents; the alpha diversity of oral and skin microbiota was relatively higher in children than in their predecessors. Gut, oral, and skin microbiome was more similar between family members than between unrelated individuals. Meanwhile, 55.05%, 61.09%, and 76.73% of amplicon sequence variants (ASVs) in children’s gut, oral, and skin microbiomes, respectively, were transmitted from all family members. Among these, the most transmissible ASVs belonged to Methylophilaceae, Solimonadaceae, Neisseriaceae, and Burkholderiaceae, which were defined as “putative familial transmissible bacteria.” Furthermore, we found that the time spent with parents/grandparents and children’s dietary preferences were important factors that influenced the proportion of the transmissible microbiome. Moreover, the majority of transmissible ASVs (85.06%), especially those of Ruminococcaceae and Lachnospiraceae, were significantly associated with the immune indices, such as CD3+, CD4+, CD8+, IgG, and IgA. IMPORTANCE Our study revealed that the children’s microbiota was partially transmitted from their family members and specific putative transmissible ASVs were associated with the immune system of children. These findings suggest that home life plays a key role in the shaping of young children’s microbiomes and has long-term health benefits.https://journals.asm.org/doi/10.1128/Spectrum.00872-21transmissionmicrobiomefamily generationgutmouthskin |
| spellingShingle | Lu Zhao Wanning Chen Yongsheng Ge Xin Lv Ying Wang Han Yu Yi Liu Dingfeng Wu Na Jiao Yuanqi Wu Daqing Lv Guoqing Zhang Fuzhong Xue Xiaohong Xu Zhongtao Gai Ruixin Zhu Lei Zhang Guoping Zhao Putative Familial Transmissible Bacteria of Various Body Niches Link with Home Environment and Children’s Immune Health Microbiology Spectrum transmission microbiome family generation gut mouth skin |
| title | Putative Familial Transmissible Bacteria of Various Body Niches Link with Home Environment and Children’s Immune Health |
| title_full | Putative Familial Transmissible Bacteria of Various Body Niches Link with Home Environment and Children’s Immune Health |
| title_fullStr | Putative Familial Transmissible Bacteria of Various Body Niches Link with Home Environment and Children’s Immune Health |
| title_full_unstemmed | Putative Familial Transmissible Bacteria of Various Body Niches Link with Home Environment and Children’s Immune Health |
| title_short | Putative Familial Transmissible Bacteria of Various Body Niches Link with Home Environment and Children’s Immune Health |
| title_sort | putative familial transmissible bacteria of various body niches link with home environment and children s immune health |
| topic | transmission microbiome family generation gut mouth skin |
| url | https://journals.asm.org/doi/10.1128/Spectrum.00872-21 |
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