Difference between the Effects of Peripheral Sensory Nerve Electrical Stimulation on the Excitability of the Primary Motor Cortex: Examination of the Combinations of Stimulus Frequency and Duration
Peripheral sensory nerve electrical stimulation (PES) excites the primary motor cortex and is expected to improve motor dysfunction post-stroke. However, previous studies have reported a variety of stimulus frequencies and stimulus duration settings, and the effects of these different combinations o...
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MDPI AG
2022-11-01
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| Online Access: | https://www.mdpi.com/2076-3425/12/12/1637 |
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| author | Masaaki Sato Hitoshi Mutai Jun Iwanami Anna Noji Sayaka Sugimoto Kana Ozawa Akira Sagari |
| author_facet | Masaaki Sato Hitoshi Mutai Jun Iwanami Anna Noji Sayaka Sugimoto Kana Ozawa Akira Sagari |
| author_sort | Masaaki Sato |
| collection | DOAJ |
| description | Peripheral sensory nerve electrical stimulation (PES) excites the primary motor cortex and is expected to improve motor dysfunction post-stroke. However, previous studies have reported a variety of stimulus frequencies and stimulus duration settings, and the effects of these different combinations on primary motor cortex excitability are not clear. We aimed to clarify the effects of different combinations of stimulus frequency and stimulus duration of PES on the excitation of primary motor cortex. Twenty-one healthy individuals (aged > 18 years, right-handed, and without a history of neurological or orthopedic disorders) were included. Each participant experienced three different stimulation frequencies (1, 10 and 50 Hz) and durations (20, 40 and 60 min). Motor-evoked potentials (MEPs) were recorded pre- and post-PES. The outcome measure was the change in primary motor cortex excitability using the MEP ratio. We used a D-optimal design of experiments and response surface analysis to define the optimal combination within nine different settings inducing more satisfying responses. The combination of stimulation frequency and stimulation time that maximized the desirability value was 10 Hz and 40 min, respectively. The results of this study may provide fundamental data for more minimally invasive and effective implementation of PES in patients with stroke. |
| first_indexed | 2024-03-09T17:16:06Z |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T17:16:06Z |
| publishDate | 2022-11-01 |
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| spelling | doaj.art-4b6fe13a8f1d4d8298451bdb6e6102302023-11-24T13:39:08ZengMDPI AGBrain Sciences2076-34252022-11-011212163710.3390/brainsci12121637Difference between the Effects of Peripheral Sensory Nerve Electrical Stimulation on the Excitability of the Primary Motor Cortex: Examination of the Combinations of Stimulus Frequency and DurationMasaaki Sato0Hitoshi Mutai1Jun Iwanami2Anna Noji3Sayaka Sugimoto4Kana Ozawa5Akira Sagari6Department of Occupational Therapy, School of Health Sciences, Faculty of Medicine, Shinshu University, Matsumoto 390-8621, JapanDepartment of Occupational Therapy, School of Health Sciences, Faculty of Medicine, Shinshu University, Matsumoto 390-8621, JapanDepartment of Occupational Therapy, School of Health Sciences, Faculty of Medicine, Shinshu University, Matsumoto 390-8621, JapanDepartment of Rehabilitation, Aizawa Hospital, Matsumoto 390-8510, JapanDepartment of Rehabilitation, Toyama Rosai Hospital, Uozu 937-0042, JapanDepartment of Rehabilitation, Suwa Kyoritsu Hospital, Okaya 393-0077, JapanDepartment of Occupational Therapy, School of Health Sciences, Faculty of Medicine, Shinshu University, Matsumoto 390-8621, JapanPeripheral sensory nerve electrical stimulation (PES) excites the primary motor cortex and is expected to improve motor dysfunction post-stroke. However, previous studies have reported a variety of stimulus frequencies and stimulus duration settings, and the effects of these different combinations on primary motor cortex excitability are not clear. We aimed to clarify the effects of different combinations of stimulus frequency and stimulus duration of PES on the excitation of primary motor cortex. Twenty-one healthy individuals (aged > 18 years, right-handed, and without a history of neurological or orthopedic disorders) were included. Each participant experienced three different stimulation frequencies (1, 10 and 50 Hz) and durations (20, 40 and 60 min). Motor-evoked potentials (MEPs) were recorded pre- and post-PES. The outcome measure was the change in primary motor cortex excitability using the MEP ratio. We used a D-optimal design of experiments and response surface analysis to define the optimal combination within nine different settings inducing more satisfying responses. The combination of stimulation frequency and stimulation time that maximized the desirability value was 10 Hz and 40 min, respectively. The results of this study may provide fundamental data for more minimally invasive and effective implementation of PES in patients with stroke.https://www.mdpi.com/2076-3425/12/12/1637electrical stimulationstimulation paradigmmotor-evoked potentialtranscranial magnetic stimulationdesign of experiments |
| spellingShingle | Masaaki Sato Hitoshi Mutai Jun Iwanami Anna Noji Sayaka Sugimoto Kana Ozawa Akira Sagari Difference between the Effects of Peripheral Sensory Nerve Electrical Stimulation on the Excitability of the Primary Motor Cortex: Examination of the Combinations of Stimulus Frequency and Duration Brain Sciences electrical stimulation stimulation paradigm motor-evoked potential transcranial magnetic stimulation design of experiments |
| title | Difference between the Effects of Peripheral Sensory Nerve Electrical Stimulation on the Excitability of the Primary Motor Cortex: Examination of the Combinations of Stimulus Frequency and Duration |
| title_full | Difference between the Effects of Peripheral Sensory Nerve Electrical Stimulation on the Excitability of the Primary Motor Cortex: Examination of the Combinations of Stimulus Frequency and Duration |
| title_fullStr | Difference between the Effects of Peripheral Sensory Nerve Electrical Stimulation on the Excitability of the Primary Motor Cortex: Examination of the Combinations of Stimulus Frequency and Duration |
| title_full_unstemmed | Difference between the Effects of Peripheral Sensory Nerve Electrical Stimulation on the Excitability of the Primary Motor Cortex: Examination of the Combinations of Stimulus Frequency and Duration |
| title_short | Difference between the Effects of Peripheral Sensory Nerve Electrical Stimulation on the Excitability of the Primary Motor Cortex: Examination of the Combinations of Stimulus Frequency and Duration |
| title_sort | difference between the effects of peripheral sensory nerve electrical stimulation on the excitability of the primary motor cortex examination of the combinations of stimulus frequency and duration |
| topic | electrical stimulation stimulation paradigm motor-evoked potential transcranial magnetic stimulation design of experiments |
| url | https://www.mdpi.com/2076-3425/12/12/1637 |
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