Microchimerism as Post-Transplant Marker of a Chronic Rejection Process
The risk of losing a transplanted organ is high, and non-invasive markers to warn of this phenomenon are still being sought. We investigated the impact of post-transplant microchimerism on the function of the transplanted kidney. The study included 100 kidney transplant recipients, mostly women. All...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-06-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/13/10603 |
| Summary: | The risk of losing a transplanted organ is high, and non-invasive markers to warn of this phenomenon are still being sought. We investigated the impact of post-transplant microchimerism on the function of the transplanted kidney. The study included 100 kidney transplant recipients, mostly women. All transplanted organs were from opposite-sex deceased donors. Microchimerism was assessed using multiplex PCR. Male DNA was detected in all urine samples from female recipients and in 13/56 blood samples from female kidney recipients. Female DNA was found in 31/44 urine samples from male recipients, but in none of the blood samples. Microchimerism in the urine of female recipients correlated positively with blood urea (Rs = 0.45; <i>p</i> = 5.84 × 10<sup>−4</sup>) and K<sup>+</sup> ions (Rs = 0.29; <i>p</i> = 0.03), while microchimerism in the blood of female recipients also correlated positively with blood urea (Rs = 0. 28; <i>p</i> = 0.04), cystatin C (Rs = 0.31; <i>p</i> = 0.02) and the number of incompatible HLA alleles (Rs = 0.42; <i>p</i> = 0.01). A history of DGF was associated with higher urinary donor DNA concentrations in female recipients.: Post-transplant microchimerism may serve as a potential marker of chronic kidney rejection. |
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| ISSN: | 1661-6596 1422-0067 |