Transient global amnesia and neurological events: the Framingham Heart Study
Background/ objective: Transient global amnesia (TGA) is a temporary amnestic syndrome characterized by lack of other focal neurological deficits. Cerebrovascular disease, migraine and seizures have been suggested as underlying mechanisms. TGA may be a risk factor for cerebrovascular or other neurol...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2013-05-01
|
| Series: | Frontiers in Neurology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00047/full |
| _version_ | 1819267847026638848 |
|---|---|
| author | Jose Rafael Romero Jose Rafael Romero Melissa eMercado Alexa S Beiser Alexa S Beiser Alexa S Beiser Aleksandra ePikula Aleksandra ePikula Sudha eSeshadri Sudha eSeshadri Margaret eKelly-Hayes Philip A Wolf Philip A Wolf Carlos S Kase Carlos S Kase |
| author_facet | Jose Rafael Romero Jose Rafael Romero Melissa eMercado Alexa S Beiser Alexa S Beiser Alexa S Beiser Aleksandra ePikula Aleksandra ePikula Sudha eSeshadri Sudha eSeshadri Margaret eKelly-Hayes Philip A Wolf Philip A Wolf Carlos S Kase Carlos S Kase |
| author_sort | Jose Rafael Romero |
| collection | DOAJ |
| description | Background/ objective: Transient global amnesia (TGA) is a temporary amnestic syndrome characterized by lack of other focal neurological deficits. Cerebrovascular disease, migraine and seizures have been suggested as underlying mechanisms. TGA may be a risk factor for cerebrovascular or other neurological events. We studied the relation of TGA, vascular risk factors, brain magnetic resonance imaging (MRI) indices of subclinical ischemia and neurological events in a community-based sample. Design/setting: A total of 12 TGA cases were ascertained using standard criteria by experienced neurologists, and matched to 41 stroke- and seizure-free controls. Vascular risk factors, brain MRI findings, and subsequent cerebrovascular or seizure events were compared in cases and controls. Participants: Framingham Heart Study (FHS) original and offspring cohort participants were included.Results: No significant differences between the groups were observed in the prevalence of vascular risk factors, or brain MRI measures. Few incident stroke/transient ischemic attacks (TIA) (1 event among the cases and 4 in controls) or subsequent seizures occurred in either group. Head CT during the acute event (n=11) and brain MRI (n=7) were negative for acute abnormalities. Electroencephalograms (EEG) (n=5) were negative for epileptiform activity. Extracranial vascular studies were negative for significant stenosis in all cases.Conclusions: In our community-based study TGA was not related to traditional vascular risk factors, or cerebrovascular disease. However, our study is limited by small sample size and power, and larger studies are required to exclude an association. |
| first_indexed | 2024-12-23T21:23:40Z |
| format | Article |
| id | doaj.art-4b72836bc3ba46c9a554a83e8a8e137a |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-12-23T21:23:40Z |
| publishDate | 2013-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-4b72836bc3ba46c9a554a83e8a8e137a2022-12-21T17:30:40ZengFrontiers Media S.A.Frontiers in Neurology1664-22952013-05-01410.3389/fneur.2013.0004747586Transient global amnesia and neurological events: the Framingham Heart StudyJose Rafael Romero0Jose Rafael Romero1Melissa eMercado2Alexa S Beiser3Alexa S Beiser4Alexa S Beiser5Aleksandra ePikula6Aleksandra ePikula7Sudha eSeshadri8Sudha eSeshadri9Margaret eKelly-Hayes10Philip A Wolf11Philip A Wolf12Carlos S Kase13Carlos S Kase14Boston University Medical CenterNHLBI’s Framingham Heart StudyBoston University Medical CenterBoston University Medical CenterBoston University School of Public HealthNHLBI’s Framingham Heart StudyBoston University Medical CenterNHLBI’s Framingham Heart StudyBoston University Medical CenterNHLBI’s Framingham Heart StudyNHLBI’s Framingham Heart StudyBoston University Medical CenterNHLBI’s Framingham Heart StudyBoston University Medical CenterNHLBI’s Framingham Heart StudyBackground/ objective: Transient global amnesia (TGA) is a temporary amnestic syndrome characterized by lack of other focal neurological deficits. Cerebrovascular disease, migraine and seizures have been suggested as underlying mechanisms. TGA may be a risk factor for cerebrovascular or other neurological events. We studied the relation of TGA, vascular risk factors, brain magnetic resonance imaging (MRI) indices of subclinical ischemia and neurological events in a community-based sample. Design/setting: A total of 12 TGA cases were ascertained using standard criteria by experienced neurologists, and matched to 41 stroke- and seizure-free controls. Vascular risk factors, brain MRI findings, and subsequent cerebrovascular or seizure events were compared in cases and controls. Participants: Framingham Heart Study (FHS) original and offspring cohort participants were included.Results: No significant differences between the groups were observed in the prevalence of vascular risk factors, or brain MRI measures. Few incident stroke/transient ischemic attacks (TIA) (1 event among the cases and 4 in controls) or subsequent seizures occurred in either group. Head CT during the acute event (n=11) and brain MRI (n=7) were negative for acute abnormalities. Electroencephalograms (EEG) (n=5) were negative for epileptiform activity. Extracranial vascular studies were negative for significant stenosis in all cases.Conclusions: In our community-based study TGA was not related to traditional vascular risk factors, or cerebrovascular disease. However, our study is limited by small sample size and power, and larger studies are required to exclude an association.http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00047/fullSeizuresStrokebrain MRITIAcerebrovascular diseasetransient global amnesia |
| spellingShingle | Jose Rafael Romero Jose Rafael Romero Melissa eMercado Alexa S Beiser Alexa S Beiser Alexa S Beiser Aleksandra ePikula Aleksandra ePikula Sudha eSeshadri Sudha eSeshadri Margaret eKelly-Hayes Philip A Wolf Philip A Wolf Carlos S Kase Carlos S Kase Transient global amnesia and neurological events: the Framingham Heart Study Frontiers in Neurology Seizures Stroke brain MRI TIA cerebrovascular disease transient global amnesia |
| title | Transient global amnesia and neurological events: the Framingham Heart Study |
| title_full | Transient global amnesia and neurological events: the Framingham Heart Study |
| title_fullStr | Transient global amnesia and neurological events: the Framingham Heart Study |
| title_full_unstemmed | Transient global amnesia and neurological events: the Framingham Heart Study |
| title_short | Transient global amnesia and neurological events: the Framingham Heart Study |
| title_sort | transient global amnesia and neurological events the framingham heart study |
| topic | Seizures Stroke brain MRI TIA cerebrovascular disease transient global amnesia |
| url | http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00047/full |
| work_keys_str_mv | AT joserafaelromero transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT joserafaelromero transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT melissaemercado transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT alexasbeiser transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT alexasbeiser transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT alexasbeiser transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT aleksandraepikula transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT aleksandraepikula transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT sudhaeseshadri transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT sudhaeseshadri transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT margaretekellyhayes transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT philipawolf transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT philipawolf transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT carlosskase transientglobalamnesiaandneurologicaleventstheframinghamheartstudy AT carlosskase transientglobalamnesiaandneurologicaleventstheframinghamheartstudy |