Brown Fat and Nutrition: Implications for Nutritional Interventions
Brown and beige adipocytes are renowned for their unique ability to generate heat through a mechanism known as thermogenesis. This process can be induced by exposure to cold, hormonal signals, drugs, and dietary factors. The activation of these thermogenic adipocytes holds promise for improving gluc...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/18/4072 |
| _version_ | 1797578242505310208 |
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| author | Lloyd Noriega Cheng-Ying Yang Chih-Hao Wang |
| author_facet | Lloyd Noriega Cheng-Ying Yang Chih-Hao Wang |
| author_sort | Lloyd Noriega |
| collection | DOAJ |
| description | Brown and beige adipocytes are renowned for their unique ability to generate heat through a mechanism known as thermogenesis. This process can be induced by exposure to cold, hormonal signals, drugs, and dietary factors. The activation of these thermogenic adipocytes holds promise for improving glucose metabolism, reducing fat accumulation, and enhancing insulin sensitivity. However, the translation of preclinical findings into effective clinical therapies poses challenges, warranting further research to identify the molecular mechanisms underlying the differentiation and function of brown and beige adipocytes. Consequently, research has focused on the development of drugs, such as mirabegron, ephedrine, and thyroid hormone, that mimic the effects of cold exposure to activate brown fat activity. Additionally, nutritional interventions have been explored as an alternative approach to minimize potential side effects. Brown fat and beige fat have emerged as promising targets for addressing nutritional imbalances, with the potential to develop strategies for mitigating the impact of metabolic diseases. Understanding the influence of nutritional factors on brown fat activity can facilitate the development of strategies to promote its activation and mitigate metabolic disorders. |
| first_indexed | 2024-03-10T22:19:14Z |
| format | Article |
| id | doaj.art-4b74b69d712d4568a7933b30ac69401e |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T22:19:14Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-4b74b69d712d4568a7933b30ac69401e2023-11-19T12:19:59ZengMDPI AGNutrients2072-66432023-09-011518407210.3390/nu15184072Brown Fat and Nutrition: Implications for Nutritional InterventionsLloyd Noriega0Cheng-Ying Yang1Chih-Hao Wang2Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 406040, TaiwanGraduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 406040, TaiwanGraduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung 406040, TaiwanBrown and beige adipocytes are renowned for their unique ability to generate heat through a mechanism known as thermogenesis. This process can be induced by exposure to cold, hormonal signals, drugs, and dietary factors. The activation of these thermogenic adipocytes holds promise for improving glucose metabolism, reducing fat accumulation, and enhancing insulin sensitivity. However, the translation of preclinical findings into effective clinical therapies poses challenges, warranting further research to identify the molecular mechanisms underlying the differentiation and function of brown and beige adipocytes. Consequently, research has focused on the development of drugs, such as mirabegron, ephedrine, and thyroid hormone, that mimic the effects of cold exposure to activate brown fat activity. Additionally, nutritional interventions have been explored as an alternative approach to minimize potential side effects. Brown fat and beige fat have emerged as promising targets for addressing nutritional imbalances, with the potential to develop strategies for mitigating the impact of metabolic diseases. Understanding the influence of nutritional factors on brown fat activity can facilitate the development of strategies to promote its activation and mitigate metabolic disorders.https://www.mdpi.com/2072-6643/15/18/4072metabolic diseasesmitochondria dysfunctionobesitydiabetesfatty liver diseasewhite adipose tissue |
| spellingShingle | Lloyd Noriega Cheng-Ying Yang Chih-Hao Wang Brown Fat and Nutrition: Implications for Nutritional Interventions Nutrients metabolic diseases mitochondria dysfunction obesity diabetes fatty liver disease white adipose tissue |
| title | Brown Fat and Nutrition: Implications for Nutritional Interventions |
| title_full | Brown Fat and Nutrition: Implications for Nutritional Interventions |
| title_fullStr | Brown Fat and Nutrition: Implications for Nutritional Interventions |
| title_full_unstemmed | Brown Fat and Nutrition: Implications for Nutritional Interventions |
| title_short | Brown Fat and Nutrition: Implications for Nutritional Interventions |
| title_sort | brown fat and nutrition implications for nutritional interventions |
| topic | metabolic diseases mitochondria dysfunction obesity diabetes fatty liver disease white adipose tissue |
| url | https://www.mdpi.com/2072-6643/15/18/4072 |
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