Development and validation of a stability-indicating HPLC method for the determination of buclizine hydrochloride in tablets and oral suspension and its application to dissolution studies

Development and validation of a stability-indicating HPLC method for the determination of buclizine hydrochloride in tablets and oral suspension and its application to dissolution studies

A method using liquid chromatography has been developed and validated for determination of buclizine in pharmaceutical formulations and in release studies. Isocratic chromatography was performed on a C18 column with methanol:water (80:20 v/v, pH 2.6) as mobile phase, at a flow rate of 1.0 mL/min, an...

Full description

Bibliographic Details
Main Authors: Gislaine Kuminek, Hellen K. Stulzer, Monika P. Tagliari, Paulo R. Oliveira, Larissa S. Bernardi, Gabriela Rauber, Simone G. Cardoso
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2012-01-01
Series:Química Nova
Subjects:
buclizine
dissolution test
liquid chromatography
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012000100036&lng=en&tlng=en

Similar Items

Similar Items