Suppression of Cancer Cell Stemness and Drug Resistance via MYC Destabilization by Deubiquitinase USP45 Inhibition with a Natural Small Molecule

Suppression of Cancer Cell Stemness and Drug Resistance via MYC Destabilization by Deubiquitinase USP45 Inhibition with a Natural Small Molecule

Cancer stem cells (CSCs) play significant roles in cancer development, drug resistance and cancer recurrence. In cancer treatments based on the CSC characteristics and inducing factors, MYC is a promising target for therapeutic molecules. Although it has been regarded as an undrugable target, its st...

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Bibliographic Details
Main Authors: Xiao Tu, Chuncheng Li, Wen Sun, Xi Tian, Qiufu Li, Shaoxin Wang, Xiaoling Ding, Zhen Huang
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Cancers
Subjects:
deubiquitinase
cancer stemness
drug resistance
natural product
Online Access:https://www.mdpi.com/2072-6694/15/3/930

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