Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia.

Global analysis of erythroid cells redox status reveals the involvement of Prdx1 and Prdx2 in the severity of beta thalassemia.

β-thalassemia is a worldwide distributed monogenic red cell disorder, characterized by an absent or reduced beta globin chain synthesis. The unbalance of alpha-gamma chain and the presence of pathological free iron promote severe oxidative damage, playing crucial a role in erythrocyte hemolysis, exa...

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Main Authors: Karen S Romanello, Karina K L Teixeira, João Pedro M O Silva, Sheila T Nagamatsu, Marcos André C Bezerra, Igor F Domingos, Diego A P Martins, Aderson S Araujo, Carolina Lanaro, Carlos A Breyer, Regiane A Ferreira, Carla Franco-Penteado, Fernando F Costa, Iran Malavazi, Luis E S Netto, Marcos A de Oliveira, Anderson F Cunha
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0208316

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