PCSK9 is not secreted from mature differentiated intestinal cells

PCSK9 is not secreted from mature differentiated intestinal cells

Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes lysosomal degradation of the LDL receptor and is a key regulator of cholesterol metabolism. After the liver, the small intestine is the second organ that highly expresses PCSK9. However, the small intestine's ability to secrete PCSK...

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Bibliographic Details
Main Authors: Moreau François, Aurélie Thédrez, Damien Garçon, Audrey Ayer, Thibaud Sotin, Wieneke Dijk, Claire Blanchard, Gilliane Chadeuf, Lucie Arnaud, Mikael Croyal, Laurianne Van Landeghem, Melissa Touvron, Xavier Prieur, Anna Roubtsova, Nabil Seidah, Annik Prat, Bertrand Cariou, Cedric Le May
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Lipid Research
Subjects:
PCSK9
intestine
cholesterol metabolism
lipoprotein metabolism
Caco-2 cell
liver-specific knockout
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752100078X

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