Oral vancomycin treatment suppresses gut trypsin activity and preserves intestinal barrier function during EAE

Oral vancomycin treatment suppresses gut trypsin activity and preserves intestinal barrier function during EAE

Summary: Studies have reported increased intestinal permeability in multiple sclerosis (MS) patients and its mouse model experimental autoimmune encephalomyelitis (EAE). However, the mechanisms driving increased intestinal permeability that in turn exacerbate neuroinflammation during EAE remain uncl...

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Bibliographic Details
Main Authors: Paola Bianchimano, Kacper Iwanowski, Emma M. Smith, Adam Cantor, Paola Leone, Gerold Bongers, Carlos G. Gonzalez, Yoon Hongsup, Joshua Elias, Howard L. Weiner, Jose C. Clemente, Stephanie K. Tankou
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:iScience
Subjects:
Human physiology
Drugs
Microbiome
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223022204

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