Interfacial Electrostatic Self‐Assembly of Amyloid Fibrils into Multifunctional Protein Films
Abstract Amyloid fibrils have generated steadily increasing traction in the development of natural and artificial materials. However, it remains a challenge to construct bulk amyloid films directly from amyloid fibrils due to their intrinsic brittleness. Here, a facile and general methodology to fab...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-03-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202206867 |
| _version_ | 1797860812578095104 |
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| author | Yangyang Han Yiping Cao Jiangtao Zhou Yang Yao Xiaodong Wu Sreenath Bolisetty Michael Diener Stephan Handschin Canhui Lu Raffaele Mezzenga |
| author_facet | Yangyang Han Yiping Cao Jiangtao Zhou Yang Yao Xiaodong Wu Sreenath Bolisetty Michael Diener Stephan Handschin Canhui Lu Raffaele Mezzenga |
| author_sort | Yangyang Han |
| collection | DOAJ |
| description | Abstract Amyloid fibrils have generated steadily increasing traction in the development of natural and artificial materials. However, it remains a challenge to construct bulk amyloid films directly from amyloid fibrils due to their intrinsic brittleness. Here, a facile and general methodology to fabricate macroscopic and tunable amyloid films via fast electrostatic self‐assembly of amyloid fibrils at the air–water interface is introduced. Benefiting from the excellent templating properties of amyloid fibrils for nanoparticles (such as conductive carbon nanotubes or magnetic Fe3O4 nanoparticles), multifunctional amyloid films with tunable properties are constructed. As proof‐of‐concept demonstrations, a magnetically oriented soft robotic swimmer with well‐confined movement trajectory is prepared. In addition, a smart magnetic sensor with high sensitivity to external magnetic fields is fabricated via the combination of the conductive and magnetic amyloid films. This strategy provides a convenient, efficient, and controllable approach for the preparation of amyloid‐based multifunctional films and related smart devices. |
| first_indexed | 2024-04-09T21:53:03Z |
| format | Article |
| id | doaj.art-4b7b85ea9b3b4e358c17b3a7a04edd47 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-04-09T21:53:03Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-4b7b85ea9b3b4e358c17b3a7a04edd472023-03-24T12:30:04ZengWileyAdvanced Science2198-38442023-03-01109n/an/a10.1002/advs.202206867Interfacial Electrostatic Self‐Assembly of Amyloid Fibrils into Multifunctional Protein FilmsYangyang Han0Yiping Cao1Jiangtao Zhou2Yang Yao3Xiaodong Wu4Sreenath Bolisetty5Michael Diener6Stephan Handschin7Canhui Lu8Raffaele Mezzenga9State Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan University Sichuan 610065 P. R. ChinaETH Zurich Department of Health Science and Technology Schmelzbergstrasse 9, LFO E23 Zurich 8092 SwitzerlandETH Zurich Department of Health Science and Technology Schmelzbergstrasse 9, LFO E23 Zurich 8092 SwitzerlandETH Zurich Department of Health Science and Technology Schmelzbergstrasse 9, LFO E23 Zurich 8092 SwitzerlandState Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan University Sichuan 610065 P. R. ChinaETH Zurich Department of Health Science and Technology Schmelzbergstrasse 9, LFO E23 Zurich 8092 SwitzerlandETH Zurich Department of Health Science and Technology Schmelzbergstrasse 9, LFO E23 Zurich 8092 SwitzerlandETH Zurich Department of Health Science and Technology Schmelzbergstrasse 9, LFO E23 Zurich 8092 SwitzerlandState Key Laboratory of Polymer Materials Engineering Polymer Research Institute of Sichuan University Sichuan 610065 P. R. ChinaETH Zurich Department of Health Science and Technology Schmelzbergstrasse 9, LFO E23 Zurich 8092 SwitzerlandAbstract Amyloid fibrils have generated steadily increasing traction in the development of natural and artificial materials. However, it remains a challenge to construct bulk amyloid films directly from amyloid fibrils due to their intrinsic brittleness. Here, a facile and general methodology to fabricate macroscopic and tunable amyloid films via fast electrostatic self‐assembly of amyloid fibrils at the air–water interface is introduced. Benefiting from the excellent templating properties of amyloid fibrils for nanoparticles (such as conductive carbon nanotubes or magnetic Fe3O4 nanoparticles), multifunctional amyloid films with tunable properties are constructed. As proof‐of‐concept demonstrations, a magnetically oriented soft robotic swimmer with well‐confined movement trajectory is prepared. In addition, a smart magnetic sensor with high sensitivity to external magnetic fields is fabricated via the combination of the conductive and magnetic amyloid films. This strategy provides a convenient, efficient, and controllable approach for the preparation of amyloid‐based multifunctional films and related smart devices.https://doi.org/10.1002/advs.202206867amyloid fibrilsamyloid filmelectrostatic interactionmagnetic sensorself‐assembly |
| spellingShingle | Yangyang Han Yiping Cao Jiangtao Zhou Yang Yao Xiaodong Wu Sreenath Bolisetty Michael Diener Stephan Handschin Canhui Lu Raffaele Mezzenga Interfacial Electrostatic Self‐Assembly of Amyloid Fibrils into Multifunctional Protein Films Advanced Science amyloid fibrils amyloid film electrostatic interaction magnetic sensor self‐assembly |
| title | Interfacial Electrostatic Self‐Assembly of Amyloid Fibrils into Multifunctional Protein Films |
| title_full | Interfacial Electrostatic Self‐Assembly of Amyloid Fibrils into Multifunctional Protein Films |
| title_fullStr | Interfacial Electrostatic Self‐Assembly of Amyloid Fibrils into Multifunctional Protein Films |
| title_full_unstemmed | Interfacial Electrostatic Self‐Assembly of Amyloid Fibrils into Multifunctional Protein Films |
| title_short | Interfacial Electrostatic Self‐Assembly of Amyloid Fibrils into Multifunctional Protein Films |
| title_sort | interfacial electrostatic self assembly of amyloid fibrils into multifunctional protein films |
| topic | amyloid fibrils amyloid film electrostatic interaction magnetic sensor self‐assembly |
| url | https://doi.org/10.1002/advs.202206867 |
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