Brainstem Modulation of Large-Scale Intrinsic Cortical Activity Correlations
Brain activity fluctuates continuously, even in the absence of changes in sensory input or motor output. These intrinsic activity fluctuations are correlated across brain regions and are spatially organized in macroscale networks. Variations in the strength, topography, and topology of correlated ac...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-10-01
|
| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2019.00340/full |
| _version_ | 1818494239464488960 |
|---|---|
| author | R. L. van den Brink T. Pfeffer T. H. Donner T. H. Donner T. H. Donner |
| author_facet | R. L. van den Brink T. Pfeffer T. H. Donner T. H. Donner T. H. Donner |
| author_sort | R. L. van den Brink |
| collection | DOAJ |
| description | Brain activity fluctuates continuously, even in the absence of changes in sensory input or motor output. These intrinsic activity fluctuations are correlated across brain regions and are spatially organized in macroscale networks. Variations in the strength, topography, and topology of correlated activity occur over time, and unfold upon a backbone of long-range anatomical connections. Subcortical neuromodulatory systems send widespread ascending projections to the cortex, and are thus ideally situated to shape the temporal and spatial structure of intrinsic correlations. These systems are also the targets of the pharmacological treatment of major neurological and psychiatric disorders, such as Parkinson’s disease, depression, and schizophrenia. Here, we review recent work that has investigated how neuromodulatory systems shape correlations of intrinsic fluctuations of large-scale cortical activity. We discuss studies in the human, monkey, and rodent brain, with a focus on non-invasive recordings of human brain activity. We provide a structured but selective overview of this work and distil a number of emerging principles. Future efforts to chart the effect of specific neuromodulators and, in particular, specific receptors, on intrinsic correlations may help identify shared or antagonistic principles between different neuromodulatory systems. Such principles can inform models of healthy brain function and may provide an important reference for understanding altered cortical dynamics that are evident in neurological and psychiatric disorders, potentially paving the way for mechanistically inspired biomarkers and individualized treatments of these disorders. |
| first_indexed | 2024-12-10T18:03:58Z |
| format | Article |
| id | doaj.art-4b7bdce7b3e2433aa6c7e5d631934386 |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-10T18:03:58Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-4b7bdce7b3e2433aa6c7e5d6319343862022-12-22T01:38:41ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612019-10-011310.3389/fnhum.2019.00340486495Brainstem Modulation of Large-Scale Intrinsic Cortical Activity CorrelationsR. L. van den Brink0T. Pfeffer1T. H. Donner2T. H. Donner3T. H. Donner4Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Psychology, University of Amsterdam, Amsterdam, NetherlandsAmsterdam Center for Brain and Cognition, Institute for Interdisciplinary Studies, Amsterdam, NetherlandsBrain activity fluctuates continuously, even in the absence of changes in sensory input or motor output. These intrinsic activity fluctuations are correlated across brain regions and are spatially organized in macroscale networks. Variations in the strength, topography, and topology of correlated activity occur over time, and unfold upon a backbone of long-range anatomical connections. Subcortical neuromodulatory systems send widespread ascending projections to the cortex, and are thus ideally situated to shape the temporal and spatial structure of intrinsic correlations. These systems are also the targets of the pharmacological treatment of major neurological and psychiatric disorders, such as Parkinson’s disease, depression, and schizophrenia. Here, we review recent work that has investigated how neuromodulatory systems shape correlations of intrinsic fluctuations of large-scale cortical activity. We discuss studies in the human, monkey, and rodent brain, with a focus on non-invasive recordings of human brain activity. We provide a structured but selective overview of this work and distil a number of emerging principles. Future efforts to chart the effect of specific neuromodulators and, in particular, specific receptors, on intrinsic correlations may help identify shared or antagonistic principles between different neuromodulatory systems. Such principles can inform models of healthy brain function and may provide an important reference for understanding altered cortical dynamics that are evident in neurological and psychiatric disorders, potentially paving the way for mechanistically inspired biomarkers and individualized treatments of these disorders.https://www.frontiersin.org/article/10.3389/fnhum.2019.00340/fullfunctional connectivitynorepinepherinedopamineacetycholineserotoninbrainstem |
| spellingShingle | R. L. van den Brink T. Pfeffer T. H. Donner T. H. Donner T. H. Donner Brainstem Modulation of Large-Scale Intrinsic Cortical Activity Correlations Frontiers in Human Neuroscience functional connectivity norepinepherine dopamine acetycholine serotonin brainstem |
| title | Brainstem Modulation of Large-Scale Intrinsic Cortical Activity Correlations |
| title_full | Brainstem Modulation of Large-Scale Intrinsic Cortical Activity Correlations |
| title_fullStr | Brainstem Modulation of Large-Scale Intrinsic Cortical Activity Correlations |
| title_full_unstemmed | Brainstem Modulation of Large-Scale Intrinsic Cortical Activity Correlations |
| title_short | Brainstem Modulation of Large-Scale Intrinsic Cortical Activity Correlations |
| title_sort | brainstem modulation of large scale intrinsic cortical activity correlations |
| topic | functional connectivity norepinepherine dopamine acetycholine serotonin brainstem |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2019.00340/full |
| work_keys_str_mv | AT rlvandenbrink brainstemmodulationoflargescaleintrinsiccorticalactivitycorrelations AT tpfeffer brainstemmodulationoflargescaleintrinsiccorticalactivitycorrelations AT thdonner brainstemmodulationoflargescaleintrinsiccorticalactivitycorrelations AT thdonner brainstemmodulationoflargescaleintrinsiccorticalactivitycorrelations AT thdonner brainstemmodulationoflargescaleintrinsiccorticalactivitycorrelations |