Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China
Background: Infection is the predominant contributor to morbidity and mortality in burn patients, and burn wound infection (BWI) is the most common reason. The objective of this research was to analyze the incidence, factors and progression of BWI, in terms of events and bacteria. Methods: Clinical...
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MDPI AG
2023-09-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/9/1432 |
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| author | Siqi Zhou Shuzhen Xiao Xuedong Wang Xuefeng Wang Lizhong Han |
| author_facet | Siqi Zhou Shuzhen Xiao Xuedong Wang Xuefeng Wang Lizhong Han |
| author_sort | Siqi Zhou |
| collection | DOAJ |
| description | Background: Infection is the predominant contributor to morbidity and mortality in burn patients, and burn wound infection (BWI) is the most common reason. The objective of this research was to analyze the incidence, factors and progression of BWI, in terms of events and bacteria. Methods: Clinical variables of all qualified patients admitted to burn wards were analyzed retrospectively in 2021 at a tertiary hospital in eastern China through univariate analysis and multivariate logistic regression. The Kaplan–Meier method was also used for plotting survival curves. Isolates and resistance data were evaluated to demonstrate the evolution of targeted antibiotics of strains from BWI. Results: A total of 580 (median age, 39.5 years (23–56 years); 372/580 (64.14%) male) patients were evaluated, 348 (60.0%) of whom experienced BWI. A variety of factors are associated with BWI. Multivariate logistic regression analysis showed that depth and area of burn and duration from burn to first hospitalization are independent risk factors for BWI. For BWI onset in these patients, 47.24% (274/580) occurred in the first week. The most frequently isolated causative organism was <i>Staphylococcus aureus</i> (15.7%) in patients with BWI. The duration of transition from Gram-positive strains (median 3 days, (2–7 days)) to Gram-negative (median 10 days, (4–17 days)) ones isolated from burn wound shrunk. Hospital length of stay was considered as a protective factor for BWI. Conclusion: The precise assessment of factors affecting BWI in burn patients enhances prompt and suitable management. Swab cultures for surveillance could be utilized to monitor the microbiological status of burn patients. |
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| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T23:06:20Z |
| publishDate | 2023-09-01 |
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| series | Antibiotics |
| spelling | doaj.art-4b7bf4dd15f34bd8a2ac2e11858cf73d2023-11-19T09:17:41ZengMDPI AGAntibiotics2079-63822023-09-01129143210.3390/antibiotics12091432Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East ChinaSiqi Zhou0Shuzhen Xiao1Xuedong Wang2Xuefeng Wang3Lizhong Han4Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, ChinaBackground: Infection is the predominant contributor to morbidity and mortality in burn patients, and burn wound infection (BWI) is the most common reason. The objective of this research was to analyze the incidence, factors and progression of BWI, in terms of events and bacteria. Methods: Clinical variables of all qualified patients admitted to burn wards were analyzed retrospectively in 2021 at a tertiary hospital in eastern China through univariate analysis and multivariate logistic regression. The Kaplan–Meier method was also used for plotting survival curves. Isolates and resistance data were evaluated to demonstrate the evolution of targeted antibiotics of strains from BWI. Results: A total of 580 (median age, 39.5 years (23–56 years); 372/580 (64.14%) male) patients were evaluated, 348 (60.0%) of whom experienced BWI. A variety of factors are associated with BWI. Multivariate logistic regression analysis showed that depth and area of burn and duration from burn to first hospitalization are independent risk factors for BWI. For BWI onset in these patients, 47.24% (274/580) occurred in the first week. The most frequently isolated causative organism was <i>Staphylococcus aureus</i> (15.7%) in patients with BWI. The duration of transition from Gram-positive strains (median 3 days, (2–7 days)) to Gram-negative (median 10 days, (4–17 days)) ones isolated from burn wound shrunk. Hospital length of stay was considered as a protective factor for BWI. Conclusion: The precise assessment of factors affecting BWI in burn patients enhances prompt and suitable management. Swab cultures for surveillance could be utilized to monitor the microbiological status of burn patients.https://www.mdpi.com/2079-6382/12/9/1432burn woundburn wound infectionepidemiologyrisk factorsresistancepathogenesis |
| spellingShingle | Siqi Zhou Shuzhen Xiao Xuedong Wang Xuefeng Wang Lizhong Han Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China Antibiotics burn wound burn wound infection epidemiology risk factors resistance pathogenesis |
| title | Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China |
| title_full | Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China |
| title_fullStr | Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China |
| title_full_unstemmed | Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China |
| title_short | Risk Factors and Pathogens of Wound Infection in Burn Inpatients from East China |
| title_sort | risk factors and pathogens of wound infection in burn inpatients from east china |
| topic | burn wound burn wound infection epidemiology risk factors resistance pathogenesis |
| url | https://www.mdpi.com/2079-6382/12/9/1432 |
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