Risk Factors and Management of Osteoporosis Post-Transplant
Bone and mineral disorders are common after organ transplantation. Osteoporosis post transplantation is associated with increased morbidity and mortality. Pathogenesis of bone disorders in this particular sub set of the population is complicated by multiple co-existing factors like preexisting bone...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/6/302 |
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| author | Karthik Kovvuru Swetha Rani Kanduri Pradeep Vaitla Rachana Marathi Shiva Gosi Desiree F. Garcia Anton Franco H. Cabeza Rivera Vishnu Garla |
| author_facet | Karthik Kovvuru Swetha Rani Kanduri Pradeep Vaitla Rachana Marathi Shiva Gosi Desiree F. Garcia Anton Franco H. Cabeza Rivera Vishnu Garla |
| author_sort | Karthik Kovvuru |
| collection | DOAJ |
| description | Bone and mineral disorders are common after organ transplantation. Osteoporosis post transplantation is associated with increased morbidity and mortality. Pathogenesis of bone disorders in this particular sub set of the population is complicated by multiple co-existing factors like preexisting bone disease, Vitamin D deficiency and parathyroid dysfunction. Risk factors include post-transplant immobilization, steroid usage, diabetes mellitus, low body mass index, older age, female sex, smoking, alcohol consumption and a sedentary lifestyle. Immunosuppressive medications post-transplant have a negative impact on outcomes, and further aggravate osteoporotic risk. Management is complex and challenging due to the sub-optimal sensitivity and specificity of non-invasive diagnostic tests, and the underutilization of bone biopsy. In this review, we summarize the prevalence, pathophysiology, diagnostic tests and management of osteoporosis in solid organ and hematopoietic stem cell transplant recipients. |
| first_indexed | 2024-03-12T05:53:22Z |
| format | Article |
| id | doaj.art-4b7ce809291e44309d6c37e5e2685a31 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T05:53:22Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-4b7ce809291e44309d6c37e5e2685a312023-09-03T04:53:09ZengMDPI AGMedicina1010-660X2020-06-015630230210.3390/medicina56060302Risk Factors and Management of Osteoporosis Post-TransplantKarthik Kovvuru0Swetha Rani Kanduri1Pradeep Vaitla2Rachana Marathi3Shiva Gosi4Desiree F. Garcia Anton5Franco H. Cabeza Rivera6Vishnu Garla7Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39156, USADivision of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39156, USADivision of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39156, USADivision of Hospital Medicine, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39156, USADepartment of Hospital Medicine, Banner Thunderbird Medical Center, Glenadale, AZ 85306, USADivision of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39156, USADivision of Nephrology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39156, USADepartment of Internal Medicine and Mississippi Center for Clinical and Translational Research, University of Mississippi Medical Center, Jackson, MS 39156, USABone and mineral disorders are common after organ transplantation. Osteoporosis post transplantation is associated with increased morbidity and mortality. Pathogenesis of bone disorders in this particular sub set of the population is complicated by multiple co-existing factors like preexisting bone disease, Vitamin D deficiency and parathyroid dysfunction. Risk factors include post-transplant immobilization, steroid usage, diabetes mellitus, low body mass index, older age, female sex, smoking, alcohol consumption and a sedentary lifestyle. Immunosuppressive medications post-transplant have a negative impact on outcomes, and further aggravate osteoporotic risk. Management is complex and challenging due to the sub-optimal sensitivity and specificity of non-invasive diagnostic tests, and the underutilization of bone biopsy. In this review, we summarize the prevalence, pathophysiology, diagnostic tests and management of osteoporosis in solid organ and hematopoietic stem cell transplant recipients.https://www.mdpi.com/1010-660X/56/6/302osteoporosisorgan transplantationbone diseasekidney transplantliver transplant |
| spellingShingle | Karthik Kovvuru Swetha Rani Kanduri Pradeep Vaitla Rachana Marathi Shiva Gosi Desiree F. Garcia Anton Franco H. Cabeza Rivera Vishnu Garla Risk Factors and Management of Osteoporosis Post-Transplant Medicina osteoporosis organ transplantation bone disease kidney transplant liver transplant |
| title | Risk Factors and Management of Osteoporosis Post-Transplant |
| title_full | Risk Factors and Management of Osteoporosis Post-Transplant |
| title_fullStr | Risk Factors and Management of Osteoporosis Post-Transplant |
| title_full_unstemmed | Risk Factors and Management of Osteoporosis Post-Transplant |
| title_short | Risk Factors and Management of Osteoporosis Post-Transplant |
| title_sort | risk factors and management of osteoporosis post transplant |
| topic | osteoporosis organ transplantation bone disease kidney transplant liver transplant |
| url | https://www.mdpi.com/1010-660X/56/6/302 |
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