Sustained Very Low Disease Activity and Remission in Psoriatic Arthritis Patients
Abstract Introduction Sustained remission should be considered the main therapeutic target in psoriatic arthritis (PsA). Very low disease activity (VLDA) and a DAPSA score ≤ 4 are the most commonly used criteria. The aim of the present study was to evaluate the rate of sustained remission in a group...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2019-08-01
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| Series: | Rheumatology and Therapy |
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| Online Access: | http://link.springer.com/article/10.1007/s40744-019-00171-w |
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| author | Ennio Lubrano Fabio Massimo Perrotta Silvia Scriffignano Laura C. Coates Philip Helliwell |
| author_facet | Ennio Lubrano Fabio Massimo Perrotta Silvia Scriffignano Laura C. Coates Philip Helliwell |
| author_sort | Ennio Lubrano |
| collection | DOAJ |
| description | Abstract Introduction Sustained remission should be considered the main therapeutic target in psoriatic arthritis (PsA). Very low disease activity (VLDA) and a DAPSA score ≤ 4 are the most commonly used criteria. The aim of the present study was to evaluate the rate of sustained remission in a group of PsA patients followed in a real-life setting. Methods All PsA patients satisfying CASPAR criteria were followed prospectively every 3–6 months, in a context of clinical practice by January 2013. Sustained remission was defined when patients achieved a DAPSA score ≤ 4 and/or VLDA for at least 12 months. The exclusion criterion was the presence of a condition of VLDA or DAPSA ≤ 4 at the baseline assessment. Kaplan–Meier survival curve was used to evaluate the survival of patients. Results A total of 147 PsA patients were evaluated for the study. Of these, 80 performed at least 12 consecutive months of follow-up. The average duration of follow-up was 24 months (range, 12–60 months). At the last follow-up, 22 patients were on csDMARDs treatment while 58 patients were on bDMARDs. Of the 80 patients, 14 (17.5%) achieved a sustained VLDA while 24 (30%) achieved sustained remission according to the DAPSA criteria. The mean duration of remission in patients achieving VLDA and DAPSA ≤ 4 was 17 months for both criteria. High baseline levels of CRP, shorter disease duration, and less pain at baseline were found to be predictors of sustained VLDA and DAPSA remission. Conclusions In our study, based on clinical practice, a sustained VLDA was achieved in 17.5% and a sustained remission according to the DAPSA criteria in 30% of patients with PsA. |
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| format | Article |
| id | doaj.art-4b7d0d8d69e44901bdce5d645213d557 |
| institution | Directory Open Access Journal |
| issn | 2198-6576 2198-6584 |
| language | English |
| last_indexed | 2024-12-13T00:08:03Z |
| publishDate | 2019-08-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Rheumatology and Therapy |
| spelling | doaj.art-4b7d0d8d69e44901bdce5d645213d5572022-12-22T00:06:08ZengAdis, Springer HealthcareRheumatology and Therapy2198-65762198-65842019-08-016452152810.1007/s40744-019-00171-wSustained Very Low Disease Activity and Remission in Psoriatic Arthritis PatientsEnnio Lubrano0Fabio Massimo Perrotta1Silvia Scriffignano2Laura C. Coates3Philip Helliwell4Dipartimento di Medicina e Scienze, della Salute “Vincenzo Tiberio”, Università degli Studi del MoliseDipartimento di Medicina e Scienze, della Salute “Vincenzo Tiberio”, Università degli Studi del MoliseDipartimento di Medicina e Scienze, della Salute “Vincenzo Tiberio”, Università degli Studi del MoliseDepartment of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of OxfordLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of LeedsAbstract Introduction Sustained remission should be considered the main therapeutic target in psoriatic arthritis (PsA). Very low disease activity (VLDA) and a DAPSA score ≤ 4 are the most commonly used criteria. The aim of the present study was to evaluate the rate of sustained remission in a group of PsA patients followed in a real-life setting. Methods All PsA patients satisfying CASPAR criteria were followed prospectively every 3–6 months, in a context of clinical practice by January 2013. Sustained remission was defined when patients achieved a DAPSA score ≤ 4 and/or VLDA for at least 12 months. The exclusion criterion was the presence of a condition of VLDA or DAPSA ≤ 4 at the baseline assessment. Kaplan–Meier survival curve was used to evaluate the survival of patients. Results A total of 147 PsA patients were evaluated for the study. Of these, 80 performed at least 12 consecutive months of follow-up. The average duration of follow-up was 24 months (range, 12–60 months). At the last follow-up, 22 patients were on csDMARDs treatment while 58 patients were on bDMARDs. Of the 80 patients, 14 (17.5%) achieved a sustained VLDA while 24 (30%) achieved sustained remission according to the DAPSA criteria. The mean duration of remission in patients achieving VLDA and DAPSA ≤ 4 was 17 months for both criteria. High baseline levels of CRP, shorter disease duration, and less pain at baseline were found to be predictors of sustained VLDA and DAPSA remission. Conclusions In our study, based on clinical practice, a sustained VLDA was achieved in 17.5% and a sustained remission according to the DAPSA criteria in 30% of patients with PsA.http://link.springer.com/article/10.1007/s40744-019-00171-wPsoriatic arthritisRemissionVery low disease activity |
| spellingShingle | Ennio Lubrano Fabio Massimo Perrotta Silvia Scriffignano Laura C. Coates Philip Helliwell Sustained Very Low Disease Activity and Remission in Psoriatic Arthritis Patients Rheumatology and Therapy Psoriatic arthritis Remission Very low disease activity |
| title | Sustained Very Low Disease Activity and Remission in Psoriatic Arthritis Patients |
| title_full | Sustained Very Low Disease Activity and Remission in Psoriatic Arthritis Patients |
| title_fullStr | Sustained Very Low Disease Activity and Remission in Psoriatic Arthritis Patients |
| title_full_unstemmed | Sustained Very Low Disease Activity and Remission in Psoriatic Arthritis Patients |
| title_short | Sustained Very Low Disease Activity and Remission in Psoriatic Arthritis Patients |
| title_sort | sustained very low disease activity and remission in psoriatic arthritis patients |
| topic | Psoriatic arthritis Remission Very low disease activity |
| url | http://link.springer.com/article/10.1007/s40744-019-00171-w |
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