Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic retinochoroiditis
This study aimed to investigate the serum levels of the cytokine TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in patients with toxoplasmosis retinochoroidits (TR) and controls. 37 patients with TR and 30 subjects with positive serology for toxoplasmosis but without history and signs...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-12-01
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600007 |
| _version_ | 1818245430522150912 |
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| author | Thais Fontes Bessa Cynthia Azeredo Cordeiro Roberto Martins Gonçalves Lucy H. Young Wesley R. Campos Fernando Oréfice Antônio L. Teixeira |
| author_facet | Thais Fontes Bessa Cynthia Azeredo Cordeiro Roberto Martins Gonçalves Lucy H. Young Wesley R. Campos Fernando Oréfice Antônio L. Teixeira |
| author_sort | Thais Fontes Bessa |
| collection | DOAJ |
| description | This study aimed to investigate the serum levels of the cytokine TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in patients with toxoplasmosis retinochoroidits (TR) and controls. 37 patients with TR and 30 subjects with positive serology for toxoplasmosis but without history and signs of uveitis were included in this study. Serum concentrations of TNF-α, sTNFR1, and sTNFR2 were determined by ELISA. Serum concentrations of TNF-α and sTNFR1 were similar in controls (mean ± SD median values; 56.57 ± 141.96 and 504.37 ± 163.87, respectively) and TR patients (mean ± SD values, 121.62 ± 217.56 and 511.15 ± 189.30, respectively). Serum concentrations of sTNFR2 were higher in the uveitis group when compared to the control group (respectively, mean ± SD values, 1734.84 ± 379.32 and 1442.75 ± 309.47; p=0.002). There was no association between the serum levels of the molecules and the time of first symptoms, severity of vitreous haze, size or localization of active lesions, levels of visual acuity, and presence of vasculitis. These results suggest that TR is associated with changes in the circulating levels of inflammatory biomarkers, but they are not correlated with local/ocular signs. |
| first_indexed | 2024-12-12T14:32:47Z |
| format | Article |
| id | doaj.art-4b7d4239933f4eaca608c105ceaafc8a |
| institution | Directory Open Access Journal |
| issn | 1413-8670 1678-4391 |
| language | English |
| last_indexed | 2024-12-12T14:32:47Z |
| publishDate | 2012-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-4b7d4239933f4eaca608c105ceaafc8a2022-12-22T00:21:28ZengElsevierBrazilian Journal of Infectious Diseases1413-86701678-43912012-12-0116654054410.1590/S1413-86702012000600007Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic retinochoroiditisThais Fontes BessaCynthia Azeredo CordeiroRoberto Martins GonçalvesLucy H. YoungWesley R. CamposFernando OréficeAntônio L. TeixeiraThis study aimed to investigate the serum levels of the cytokine TNF-α and its soluble receptors (sTNFR1 and sTNFR2) in patients with toxoplasmosis retinochoroidits (TR) and controls. 37 patients with TR and 30 subjects with positive serology for toxoplasmosis but without history and signs of uveitis were included in this study. Serum concentrations of TNF-α, sTNFR1, and sTNFR2 were determined by ELISA. Serum concentrations of TNF-α and sTNFR1 were similar in controls (mean ± SD median values; 56.57 ± 141.96 and 504.37 ± 163.87, respectively) and TR patients (mean ± SD values, 121.62 ± 217.56 and 511.15 ± 189.30, respectively). Serum concentrations of sTNFR2 were higher in the uveitis group when compared to the control group (respectively, mean ± SD values, 1734.84 ± 379.32 and 1442.75 ± 309.47; p=0.002). There was no association between the serum levels of the molecules and the time of first symptoms, severity of vitreous haze, size or localization of active lesions, levels of visual acuity, and presence of vasculitis. These results suggest that TR is associated with changes in the circulating levels of inflammatory biomarkers, but they are not correlated with local/ocular signs.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600007Toxoplasmosis UveitisTNF-alphaSoluble TNF receptors |
| spellingShingle | Thais Fontes Bessa Cynthia Azeredo Cordeiro Roberto Martins Gonçalves Lucy H. Young Wesley R. Campos Fernando Oréfice Antônio L. Teixeira Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic retinochoroiditis Brazilian Journal of Infectious Diseases Toxoplasmosis Uveitis TNF-alpha Soluble TNF receptors |
| title | Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic retinochoroiditis |
| title_full | Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic retinochoroiditis |
| title_fullStr | Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic retinochoroiditis |
| title_full_unstemmed | Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic retinochoroiditis |
| title_short | Increased serum levels of soluble tumor necrosis factor receptor-2 (sTNFR2) in patients with active toxoplasmic retinochoroiditis |
| title_sort | increased serum levels of soluble tumor necrosis factor receptor 2 stnfr2 in patients with active toxoplasmic retinochoroiditis |
| topic | Toxoplasmosis Uveitis TNF-alpha Soluble TNF receptors |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600007 |
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