Multifaceted roles of CCAR family proteins in the DNA damage response and cancer
Abstract The cell cycle apoptosis regulator (CCAR) family of proteins consists of two proteins, CCAR1 and CCAR2, that play a variety of roles in cellular physiology and pathology. These multidomain proteins are able to perform multiple interactions and functions, playing roles in processes such as s...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2024-01-01
|
| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-023-01139-1 |
| _version_ | 1797275749472796672 |
|---|---|
| author | D. Lugano L. Barrett S. D. Westerheide Y. Kee |
| author_facet | D. Lugano L. Barrett S. D. Westerheide Y. Kee |
| author_sort | D. Lugano |
| collection | DOAJ |
| description | Abstract The cell cycle apoptosis regulator (CCAR) family of proteins consists of two proteins, CCAR1 and CCAR2, that play a variety of roles in cellular physiology and pathology. These multidomain proteins are able to perform multiple interactions and functions, playing roles in processes such as stress responses, metabolism, and the DNA damage response. The evolutionary conservation of CCAR family proteins allows their study in model organisms such as Caenorhabditis elegans, where a role for CCAR in aging was revealed. This review particularly highlights the multifaceted roles of CCAR family proteins and their implications in the DNA damage response and in cancer biology. |
| first_indexed | 2024-03-07T15:17:57Z |
| format | Article |
| id | doaj.art-4b7d910d48d745569201546b6c023edf |
| institution | Directory Open Access Journal |
| issn | 2092-6413 |
| language | English |
| last_indexed | 2024-03-07T15:17:57Z |
| publishDate | 2024-01-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-4b7d910d48d745569201546b6c023edf2024-03-05T17:47:54ZengNature Publishing GroupExperimental and Molecular Medicine2092-64132024-01-01561596510.1038/s12276-023-01139-1Multifaceted roles of CCAR family proteins in the DNA damage response and cancerD. Lugano0L. Barrett1S. D. Westerheide2Y. Kee3Department of Molecular Biosciences, College of Arts and Sciences, University of South FloridaDepartment of Molecular Biosciences, College of Arts and Sciences, University of South FloridaDepartment of Molecular Biosciences, College of Arts and Sciences, University of South FloridaDepartment of New Biology, Daegu Gyeongbuk Institute of Science and Technology (DGIST)Abstract The cell cycle apoptosis regulator (CCAR) family of proteins consists of two proteins, CCAR1 and CCAR2, that play a variety of roles in cellular physiology and pathology. These multidomain proteins are able to perform multiple interactions and functions, playing roles in processes such as stress responses, metabolism, and the DNA damage response. The evolutionary conservation of CCAR family proteins allows their study in model organisms such as Caenorhabditis elegans, where a role for CCAR in aging was revealed. This review particularly highlights the multifaceted roles of CCAR family proteins and their implications in the DNA damage response and in cancer biology.https://doi.org/10.1038/s12276-023-01139-1 |
| spellingShingle | D. Lugano L. Barrett S. D. Westerheide Y. Kee Multifaceted roles of CCAR family proteins in the DNA damage response and cancer Experimental and Molecular Medicine |
| title | Multifaceted roles of CCAR family proteins in the DNA damage response and cancer |
| title_full | Multifaceted roles of CCAR family proteins in the DNA damage response and cancer |
| title_fullStr | Multifaceted roles of CCAR family proteins in the DNA damage response and cancer |
| title_full_unstemmed | Multifaceted roles of CCAR family proteins in the DNA damage response and cancer |
| title_short | Multifaceted roles of CCAR family proteins in the DNA damage response and cancer |
| title_sort | multifaceted roles of ccar family proteins in the dna damage response and cancer |
| url | https://doi.org/10.1038/s12276-023-01139-1 |
| work_keys_str_mv | AT dlugano multifacetedrolesofccarfamilyproteinsinthednadamageresponseandcancer AT lbarrett multifacetedrolesofccarfamilyproteinsinthednadamageresponseandcancer AT sdwesterheide multifacetedrolesofccarfamilyproteinsinthednadamageresponseandcancer AT ykee multifacetedrolesofccarfamilyproteinsinthednadamageresponseandcancer |