Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s Disease
Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by the loss of dopaminergic neurons. The vast majority of PD patients develop the disease sporadically and it is assumed that the cause lies in polygenic and environmental components. The overall polygenic ri...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/11/10/1030 |
| _version_ | 1797514096859414528 |
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| author | Mohammad Dehestani Hui Liu Thomas Gasser |
| author_facet | Mohammad Dehestani Hui Liu Thomas Gasser |
| author_sort | Mohammad Dehestani |
| collection | DOAJ |
| description | Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by the loss of dopaminergic neurons. The vast majority of PD patients develop the disease sporadically and it is assumed that the cause lies in polygenic and environmental components. The overall polygenic risk is the result of a large number of common low-risk variants discovered by large genome-wide association studies (GWAS). Polygenic risk scores (PRS), generated by compiling genome-wide significant variants, are a useful prognostic tool that quantifies the cumulative effect of genetic risk in a patient and in this way helps to identify high-risk patients. Although there are limitations to the construction and application of PRS, such as considerations of limited genetic underpinning of diseases explained by SNPs and generalizability of PRS to other populations, this personalized risk prediction could make a promising contribution to stratified medicine and tailored therapeutic interventions in the future. |
| first_indexed | 2024-03-10T06:26:48Z |
| format | Article |
| id | doaj.art-4b7ee5891ffe44508f36e631e291fade |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T06:26:48Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-4b7ee5891ffe44508f36e631e291fade2023-11-22T18:49:35ZengMDPI AGJournal of Personalized Medicine2075-44262021-10-011110103010.3390/jpm11101030Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s DiseaseMohammad Dehestani0Hui Liu1Thomas Gasser2Department of Neurodegenerative Disease, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, GermanyDepartment of Neurodegenerative Disease, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, GermanyDepartment of Neurodegenerative Disease, Hertie Institute for Clinical Brain Research, University of Tuebingen, 72076 Tuebingen, GermanyParkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by the loss of dopaminergic neurons. The vast majority of PD patients develop the disease sporadically and it is assumed that the cause lies in polygenic and environmental components. The overall polygenic risk is the result of a large number of common low-risk variants discovered by large genome-wide association studies (GWAS). Polygenic risk scores (PRS), generated by compiling genome-wide significant variants, are a useful prognostic tool that quantifies the cumulative effect of genetic risk in a patient and in this way helps to identify high-risk patients. Although there are limitations to the construction and application of PRS, such as considerations of limited genetic underpinning of diseases explained by SNPs and generalizability of PRS to other populations, this personalized risk prediction could make a promising contribution to stratified medicine and tailored therapeutic interventions in the future.https://www.mdpi.com/2075-4426/11/10/1030Parkinson’s diseasepolygenic risk scorespersonalized medicine |
| spellingShingle | Mohammad Dehestani Hui Liu Thomas Gasser Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s Disease Journal of Personalized Medicine Parkinson’s disease polygenic risk scores personalized medicine |
| title | Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s Disease |
| title_full | Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s Disease |
| title_fullStr | Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s Disease |
| title_full_unstemmed | Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s Disease |
| title_short | Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson’s Disease |
| title_sort | polygenic risk scores contribute to personalized medicine of parkinson s disease |
| topic | Parkinson’s disease polygenic risk scores personalized medicine |
| url | https://www.mdpi.com/2075-4426/11/10/1030 |
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