Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease
Background: Genetic factors have a well-known influence on Parkinson's disease (PD) susceptibility; however, no previous studies have investigated the influence of SNCA mutations on the natural history of PD using a prospective follow-up study. The aim of this study was to assess the risk facto...
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnagi.2019.00110/full |
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| author | Ningdi Luo Yuanyuan Li Mengyue Niu Liche Zhou Mengsha Yao Lin Zhu Guanyu Ye Wenyan Kang Wenyan Kang Jun Liu Jun Liu |
| author_facet | Ningdi Luo Yuanyuan Li Mengyue Niu Liche Zhou Mengsha Yao Lin Zhu Guanyu Ye Wenyan Kang Wenyan Kang Jun Liu Jun Liu |
| author_sort | Ningdi Luo |
| collection | DOAJ |
| description | Background: Genetic factors have a well-known influence on Parkinson's disease (PD) susceptibility; however, no previous studies have investigated the influence of SNCA mutations on the natural history of PD using a prospective follow-up study. The aim of this study was to assess the risk factors of variation of SNCA on the prognosis symptoms of PD patients.Methods: Fifty PD patients were recruited with 38 v-PSG confirmed PD+RBD patients, and the median follow-up period was 30 months. All patients underwent a comprehensive clinical evaluation at baseline and follow-up, and six SNPs of SNCA (rs356165, rs3857053, rs1045722, rs894278, rs356186, and rs356219) were analyzed. Cox proportional hazards regression models and Kaplan–Meier plot analysis were used to assess the associations between the SNCA variation and the primary and secondary progression outcomes.Results: Based on the clinical assessment, we found that hyposmia was substantially easier to aggravate. Regression analysis showed that patients with the T allele of rs1045722 and the G allele of rs356219 presented a 34 and 20% decreased risk of progression to the H-Y stage, respectively (p = 0.022; p = 0.005). While for rs894278, G allele patients showed a 47% decreased risk of olfactory dysfunction (p = 0.029). Further subgroup analysis showed that PD+RBD patients with rs356219/G exhibited a 30% and 20% decreased risk of progression on the H-Y stage and MoCA score (p = 0.038; p = 0.045).Conclusions: Our results indicated that genetic variation in SNCA may contribute to variability natural progression of PD and could possibly be used as a prognostic marker. |
| first_indexed | 2024-12-20T02:43:36Z |
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| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-20T02:43:36Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-4b7f3fa558964e6c8aaa24770caedf612022-12-21T19:56:15ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652019-05-011110.3389/fnagi.2019.00110450626Variants in the SNCA Locus Are Associated With the Progression of Parkinson's DiseaseNingdi Luo0Yuanyuan Li1Mengyue Niu2Liche Zhou3Mengsha Yao4Lin Zhu5Guanyu Ye6Wenyan Kang7Wenyan Kang8Jun Liu9Jun Liu10Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaRuijin Hospital North Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaDepartment of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, ChinaCAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai, ChinaBackground: Genetic factors have a well-known influence on Parkinson's disease (PD) susceptibility; however, no previous studies have investigated the influence of SNCA mutations on the natural history of PD using a prospective follow-up study. The aim of this study was to assess the risk factors of variation of SNCA on the prognosis symptoms of PD patients.Methods: Fifty PD patients were recruited with 38 v-PSG confirmed PD+RBD patients, and the median follow-up period was 30 months. All patients underwent a comprehensive clinical evaluation at baseline and follow-up, and six SNPs of SNCA (rs356165, rs3857053, rs1045722, rs894278, rs356186, and rs356219) were analyzed. Cox proportional hazards regression models and Kaplan–Meier plot analysis were used to assess the associations between the SNCA variation and the primary and secondary progression outcomes.Results: Based on the clinical assessment, we found that hyposmia was substantially easier to aggravate. Regression analysis showed that patients with the T allele of rs1045722 and the G allele of rs356219 presented a 34 and 20% decreased risk of progression to the H-Y stage, respectively (p = 0.022; p = 0.005). While for rs894278, G allele patients showed a 47% decreased risk of olfactory dysfunction (p = 0.029). Further subgroup analysis showed that PD+RBD patients with rs356219/G exhibited a 30% and 20% decreased risk of progression on the H-Y stage and MoCA score (p = 0.038; p = 0.045).Conclusions: Our results indicated that genetic variation in SNCA may contribute to variability natural progression of PD and could possibly be used as a prognostic marker.https://www.frontiersin.org/article/10.3389/fnagi.2019.00110/fullParkinson's diseaseRBDSNCASNPdisease progression |
| spellingShingle | Ningdi Luo Yuanyuan Li Mengyue Niu Liche Zhou Mengsha Yao Lin Zhu Guanyu Ye Wenyan Kang Wenyan Kang Jun Liu Jun Liu Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease Frontiers in Aging Neuroscience Parkinson's disease RBD SNCA SNP disease progression |
| title | Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease |
| title_full | Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease |
| title_fullStr | Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease |
| title_full_unstemmed | Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease |
| title_short | Variants in the SNCA Locus Are Associated With the Progression of Parkinson's Disease |
| title_sort | variants in the snca locus are associated with the progression of parkinson s disease |
| topic | Parkinson's disease RBD SNCA SNP disease progression |
| url | https://www.frontiersin.org/article/10.3389/fnagi.2019.00110/full |
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