Update on New Aspects of the Renin-Angiotensin System in Hepatic Fibrosis and Portal Hypertension: Implications for Novel Therapeutic Options

Update on New Aspects of the Renin-Angiotensin System in Hepatic Fibrosis and Portal Hypertension: Implications for Novel Therapeutic Options

There is considerable experimental evidence that the renin angiotensin system (RAS) plays a central role in both hepatic fibrogenesis and portal hypertension. Angiotensin converting enzyme (ACE), a key enzyme of the classical RAS, converts angiotensin I (Ang I) to angiotensin II (Ang II), which acts...

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Bibliographic Details
Main Authors: Indu G. Rajapaksha, Lakmie S. Gunarathne, Peter W. Angus, Chandana B. Herath
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Journal of Clinical Medicine
Subjects:
liver fibrosis and cirrhosis
portal hypertension
renin angiotensin system
angiotensin converting enzyme 2
angiotensin-(1–7)
Mas related G protein-coupled receptor type-D
Online Access:https://www.mdpi.com/2077-0383/10/4/702

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