Get real: Orbitofrontal cortex mediates the ability to sense reality in early adolescents
Abstract Introduction Orbitofrontal reality filtering (ORFi) is a memory mechanism that distinguishes whether a thought is relevant to present reality or not. In adults, it is mediated by the orbitofrontal cortex (OFC). This region is still not fully developed in preteenagers, but ORFi is already ac...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-04-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.1552 |
| _version_ | 1819170365937549312 |
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| author | Maria Chiara Liverani Lorena G. A. Freitas Vanessa Siffredi Greta Mikneviciute Roberto Martuzzi Djalel‐Eddine Meskaldij Cristina Borradori Tolsa Russia Ha‐Vinh Leuchter Armin Schnider Dimitri Van De Ville Petra Susan Hüppi |
| author_facet | Maria Chiara Liverani Lorena G. A. Freitas Vanessa Siffredi Greta Mikneviciute Roberto Martuzzi Djalel‐Eddine Meskaldij Cristina Borradori Tolsa Russia Ha‐Vinh Leuchter Armin Schnider Dimitri Van De Ville Petra Susan Hüppi |
| author_sort | Maria Chiara Liverani |
| collection | DOAJ |
| description | Abstract Introduction Orbitofrontal reality filtering (ORFi) is a memory mechanism that distinguishes whether a thought is relevant to present reality or not. In adults, it is mediated by the orbitofrontal cortex (OFC). This region is still not fully developed in preteenagers, but ORFi is already active from age 7. Here, we probe the neural correlates of ORFi in early adolescents, hypothesizing that OFC mediates the sense of reality in this population. Methods Functional magnetic resonance images (fMRI) were acquired in 22 early adolescents during a task composed of two runs: run 1 measuring recognition capacity; run 2 measuring ORFi; each containing two types of images (conditions): distractors (D: images seen for the first time in the current run) and targets (T: images seen for the second time in the current run). Group region of interest (ROI) analysis was performed in a flexible factorial design with two factors (run and condition) using SPM12. Results We found significant main effects for the experimental run and condition. The bilateral OFC activation was higher during ORFi than during the first run. Additionally, the OFC was more active while processing distractors than targets. Conclusion These results confirm, for the first time, the role of OFC in reality filtering in early adolescents. |
| first_indexed | 2024-12-22T19:34:15Z |
| format | Article |
| id | doaj.art-4b829118ad7e4edc90943c0b80ae64d5 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-12-22T19:34:15Z |
| publishDate | 2020-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-4b829118ad7e4edc90943c0b80ae64d52022-12-21T18:15:01ZengWileyBrain and Behavior2162-32792020-04-01104n/an/a10.1002/brb3.1552Get real: Orbitofrontal cortex mediates the ability to sense reality in early adolescentsMaria Chiara Liverani0Lorena G. A. Freitas1Vanessa Siffredi2Greta Mikneviciute3Roberto Martuzzi4Djalel‐Eddine Meskaldij5Cristina Borradori Tolsa6Russia Ha‐Vinh Leuchter7Armin Schnider8Dimitri Van De Ville9Petra Susan Hüppi10Department of Paediatrics, Gynecology and Obstetrics Division of Development and Growth Geneva University Hospitals Geneva SwitzerlandDepartment of Paediatrics, Gynecology and Obstetrics Division of Development and Growth Geneva University Hospitals Geneva SwitzerlandDepartment of Paediatrics, Gynecology and Obstetrics Division of Development and Growth Geneva University Hospitals Geneva SwitzerlandDepartment of Paediatrics, Gynecology and Obstetrics Division of Development and Growth Geneva University Hospitals Geneva SwitzerlandFoundation Campus Biotech Geneva Geneva SwitzerlandDepartment of Paediatrics, Gynecology and Obstetrics Division of Development and Growth Geneva University Hospitals Geneva SwitzerlandDepartment of Paediatrics, Gynecology and Obstetrics Division of Development and Growth Geneva University Hospitals Geneva SwitzerlandDepartment of Paediatrics, Gynecology and Obstetrics Division of Development and Growth Geneva University Hospitals Geneva SwitzerlandDepartment of Clinical Neurosciences Division of Neurorehabilitation Geneva University Hospitals Geneva SwitzerlandInstitute of Bioengineering École Polytechnique Fédérale de Lausanne Lausanne SwitzerlandDepartment of Paediatrics, Gynecology and Obstetrics Division of Development and Growth Geneva University Hospitals Geneva SwitzerlandAbstract Introduction Orbitofrontal reality filtering (ORFi) is a memory mechanism that distinguishes whether a thought is relevant to present reality or not. In adults, it is mediated by the orbitofrontal cortex (OFC). This region is still not fully developed in preteenagers, but ORFi is already active from age 7. Here, we probe the neural correlates of ORFi in early adolescents, hypothesizing that OFC mediates the sense of reality in this population. Methods Functional magnetic resonance images (fMRI) were acquired in 22 early adolescents during a task composed of two runs: run 1 measuring recognition capacity; run 2 measuring ORFi; each containing two types of images (conditions): distractors (D: images seen for the first time in the current run) and targets (T: images seen for the second time in the current run). Group region of interest (ROI) analysis was performed in a flexible factorial design with two factors (run and condition) using SPM12. Results We found significant main effects for the experimental run and condition. The bilateral OFC activation was higher during ORFi than during the first run. Additionally, the OFC was more active while processing distractors than targets. Conclusion These results confirm, for the first time, the role of OFC in reality filtering in early adolescents.https://doi.org/10.1002/brb3.1552early adolescentsfMRImemoryorbitofrontal cortexorbitofrontal reality filtering |
| spellingShingle | Maria Chiara Liverani Lorena G. A. Freitas Vanessa Siffredi Greta Mikneviciute Roberto Martuzzi Djalel‐Eddine Meskaldij Cristina Borradori Tolsa Russia Ha‐Vinh Leuchter Armin Schnider Dimitri Van De Ville Petra Susan Hüppi Get real: Orbitofrontal cortex mediates the ability to sense reality in early adolescents Brain and Behavior early adolescents fMRI memory orbitofrontal cortex orbitofrontal reality filtering |
| title | Get real: Orbitofrontal cortex mediates the ability to sense reality in early adolescents |
| title_full | Get real: Orbitofrontal cortex mediates the ability to sense reality in early adolescents |
| title_fullStr | Get real: Orbitofrontal cortex mediates the ability to sense reality in early adolescents |
| title_full_unstemmed | Get real: Orbitofrontal cortex mediates the ability to sense reality in early adolescents |
| title_short | Get real: Orbitofrontal cortex mediates the ability to sense reality in early adolescents |
| title_sort | get real orbitofrontal cortex mediates the ability to sense reality in early adolescents |
| topic | early adolescents fMRI memory orbitofrontal cortex orbitofrontal reality filtering |
| url | https://doi.org/10.1002/brb3.1552 |
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