The Protein Secretome Is Altered in Rectal Cancer Tissue Compared to Normal Rectal Tissue, and Alterations in the Secretome Induce Enhanced Innate Immune Responses
Locally advanced rectal cancer is treated with neoadjuvant-chemoradiotherapy; however, only ~22% of patients achieve a complete response, and resistance mechanisms are poorly understood. The role of inflammation and immune cell biology in this setting is under-investigated. In this study, we profile...
Main Authors: | Aisling B. Heeran, Margaret R. Dunne, Maria E. Morrissey, Croí E. Buckley, Niamh Clarke, Aoife Cannon, Noel E. Donlon, Timothy S. Nugent, Michael Durand, Cara Dunne, John O. Larkin, Brian Mehigan, Paul McCormick, Niamh Lynam-Lennon, Jacintha O’Sullivan |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2021-02-01
|
Series: | Cancers |
Subjects: | |
Online Access: | https://www.mdpi.com/2072-6694/13/3/571 |
Similar Items
-
Energy Metabolism Is Altered in Radioresistant Rectal Cancer
by: Croí E. Buckley, et al.
Published: (2023-04-01) -
Metformin is a metabolic modulator and radiosensitiser in rectal cancer
by: Croí E. Buckley, et al.
Published: (2023-08-01) -
Opposing Immune-Metabolic Signature in Visceral Versus Subcutaneous Adipose Tissue in Patients with Adenocarcinoma of the Oesophagus and the Oesophagogastric Junction
by: Aisling B. Heeran, et al.
Published: (2021-11-01) -
Cytokine-Mediated Alterations of Human Cardiac Fibroblast’s Secretome
by: Hanna Bräuninger, et al.
Published: (2021-11-01) -
Oncolytic Virus Therapy Alters the Secretome of Targeted Glioblastoma Cells
by: Jakub Godlewski, et al.
Published: (2021-03-01)