Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation

Insights Into Peptide Inhibition of Alpha-Synuclein Aggregation

α-Synuclein (aSyn) aggregation is an attractive target for therapeutic development for a range of neurodegenerative conditions, collectively termed synucleinopathies. Here, we probe the mechanism of action of a peptide 4554W, (KDGIVNGVKA), previously identified through intracellular library screenin...

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Bibliographic Details
Main Authors: James H. Torpey, Richard M. Meade, Ravina Mistry, Jody M. Mason, Jillian Madine
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Neuroscience
Subjects:
alpha-synuclein
electron microscopy
neurodegenerative disease
NMR
Parkinson disease
peptide interaction
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.561462/full

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