Optimized Design and Preparation of Ag Nanoparticle Multilayer SERS Substrates with Excellent Sensing Performance
Nanoparticle multilayer substrates usually exhibit excellent SERS activity due to multi-dimensional plasmon coupling. However, simply increasing the layers will lead to several problems, such as complex manufacturing procedures, reduced uniformity and poor reproducibility. In this paper, the local e...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
|
| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/13/1/52 |
| _version_ | 1797445394636996608 |
|---|---|
| author | Ping Wen Feng Yang Xiaoling Hu Yi Xu Shu Wan Li Chen |
| author_facet | Ping Wen Feng Yang Xiaoling Hu Yi Xu Shu Wan Li Chen |
| author_sort | Ping Wen |
| collection | DOAJ |
| description | Nanoparticle multilayer substrates usually exhibit excellent SERS activity due to multi-dimensional plasmon coupling. However, simply increasing the layers will lead to several problems, such as complex manufacturing procedures, reduced uniformity and poor reproducibility. In this paper, the local electric field (LEF) characteristics of a Ag nanoparticle (AgNP) multilayer were systematically studied through finite element simulations. We found that, on the glass support, the LEF intensity improved with the increase in the layers of AgNPs. However, the maximum LEF could be obtained with only two layers of AgNPs on the Au film support, and it was much stronger than the optimal value of the former. To verify the simulation results, we have successfully prepared one to four layers of AgNPs on both supports with a liquid–liquid interface self-assembly method, and carried out a series of SERS measurements. The experimental results were in good agreement with the simulations. Finally, the optimized SERS substrate, the 2-AgNP@Au film, showed an ultra-high SERS sensitivity, along with an excellent signal uniformity, which had a detection ability of 1 × 10<sup>−15</sup> M for the Rhodamine 6G (R6G) and a relative standard deviation (RSD) of 11% for the signal intensity. Our study provides important theoretical guidance and a technical basis for the optimized design and application of high-performance SERS substrates. |
| first_indexed | 2024-03-09T13:25:13Z |
| format | Article |
| id | doaj.art-4b85961779394e0d8668b554272e1f06 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T13:25:13Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-4b85961779394e0d8668b554272e1f062023-11-30T21:24:48ZengMDPI AGBiosensors2079-63742022-12-011315210.3390/bios13010052Optimized Design and Preparation of Ag Nanoparticle Multilayer SERS Substrates with Excellent Sensing PerformancePing Wen0Feng Yang1Xiaoling Hu2Yi Xu3Shu Wan4Li Chen5Key Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, College of Optoelectronic Engineering, Chongqing University, Chongqing 400044, ChinaSchool of Artificial Intelligence, Chongqing Technology and Business University, Chongqing 400067, ChinaThe Water Quality Monitoring Network of National Urban Water Supply Monitoring Station of Chongqing, Chongqing 400074, ChinaKey Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, College of Optoelectronic Engineering, Chongqing University, Chongqing 400044, ChinaKey Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, College of Optoelectronic Engineering, Chongqing University, Chongqing 400044, ChinaKey Laboratory of Optoelectronic Technology and Systems, Ministry of Education, Key Disciplines Lab of Novel Micro-Nano Devices and System Technology, College of Optoelectronic Engineering, Chongqing University, Chongqing 400044, ChinaNanoparticle multilayer substrates usually exhibit excellent SERS activity due to multi-dimensional plasmon coupling. However, simply increasing the layers will lead to several problems, such as complex manufacturing procedures, reduced uniformity and poor reproducibility. In this paper, the local electric field (LEF) characteristics of a Ag nanoparticle (AgNP) multilayer were systematically studied through finite element simulations. We found that, on the glass support, the LEF intensity improved with the increase in the layers of AgNPs. However, the maximum LEF could be obtained with only two layers of AgNPs on the Au film support, and it was much stronger than the optimal value of the former. To verify the simulation results, we have successfully prepared one to four layers of AgNPs on both supports with a liquid–liquid interface self-assembly method, and carried out a series of SERS measurements. The experimental results were in good agreement with the simulations. Finally, the optimized SERS substrate, the 2-AgNP@Au film, showed an ultra-high SERS sensitivity, along with an excellent signal uniformity, which had a detection ability of 1 × 10<sup>−15</sup> M for the Rhodamine 6G (R6G) and a relative standard deviation (RSD) of 11% for the signal intensity. Our study provides important theoretical guidance and a technical basis for the optimized design and application of high-performance SERS substrates.https://www.mdpi.com/2079-6374/13/1/52SERSlocal electric field (LEF)Ag nanoparticle (AgNP) multilayerpropagating surface plasmons (PSPs) |
| spellingShingle | Ping Wen Feng Yang Xiaoling Hu Yi Xu Shu Wan Li Chen Optimized Design and Preparation of Ag Nanoparticle Multilayer SERS Substrates with Excellent Sensing Performance Biosensors SERS local electric field (LEF) Ag nanoparticle (AgNP) multilayer propagating surface plasmons (PSPs) |
| title | Optimized Design and Preparation of Ag Nanoparticle Multilayer SERS Substrates with Excellent Sensing Performance |
| title_full | Optimized Design and Preparation of Ag Nanoparticle Multilayer SERS Substrates with Excellent Sensing Performance |
| title_fullStr | Optimized Design and Preparation of Ag Nanoparticle Multilayer SERS Substrates with Excellent Sensing Performance |
| title_full_unstemmed | Optimized Design and Preparation of Ag Nanoparticle Multilayer SERS Substrates with Excellent Sensing Performance |
| title_short | Optimized Design and Preparation of Ag Nanoparticle Multilayer SERS Substrates with Excellent Sensing Performance |
| title_sort | optimized design and preparation of ag nanoparticle multilayer sers substrates with excellent sensing performance |
| topic | SERS local electric field (LEF) Ag nanoparticle (AgNP) multilayer propagating surface plasmons (PSPs) |
| url | https://www.mdpi.com/2079-6374/13/1/52 |
| work_keys_str_mv | AT pingwen optimizeddesignandpreparationofagnanoparticlemultilayerserssubstrateswithexcellentsensingperformance AT fengyang optimizeddesignandpreparationofagnanoparticlemultilayerserssubstrateswithexcellentsensingperformance AT xiaolinghu optimizeddesignandpreparationofagnanoparticlemultilayerserssubstrateswithexcellentsensingperformance AT yixu optimizeddesignandpreparationofagnanoparticlemultilayerserssubstrateswithexcellentsensingperformance AT shuwan optimizeddesignandpreparationofagnanoparticlemultilayerserssubstrateswithexcellentsensingperformance AT lichen optimizeddesignandpreparationofagnanoparticlemultilayerserssubstrateswithexcellentsensingperformance |