Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization
Coronary artery bypass revascularization is still the optimal treatment for complex coronary artery disease with good long-term results. The relation between inflammatory activation in the post-operative period and the long-term prognosis was already postulated. The possible predictive role of preop...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754600/?tool=EBI |
| _version_ | 1811195993740279808 |
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| author | Tomasz Urbanowicz Anna Olasińska-Wiśniewska Michał Michalak Bartłomiej Perek Ahmed Al-Imam Michał Rodzki Anna Witkowska Ewa Straburzyńska-Migaj Michał Bociański Marcin Misterski Maciej Lesiak Marek Jemielity |
| author_facet | Tomasz Urbanowicz Anna Olasińska-Wiśniewska Michał Michalak Bartłomiej Perek Ahmed Al-Imam Michał Rodzki Anna Witkowska Ewa Straburzyńska-Migaj Michał Bociański Marcin Misterski Maciej Lesiak Marek Jemielity |
| author_sort | Tomasz Urbanowicz |
| collection | DOAJ |
| description | Coronary artery bypass revascularization is still the optimal treatment for complex coronary artery disease with good long-term results. The relation between inflammatory activation in the post-operative period and the long-term prognosis was already postulated. The possible predictive role of preoperative inflammatory indexes after the off-pump coronary artery bypass grafting technique on long term survival was the aim of the study. Study population included 171 patients with a median age of 64 years (59–64) operated on using off-pump technique between January and December 2014. Patients enrolled in the current study were followed-up for 8 years. We conducted a multivariable analysis of pre-operative and post-operative inflammatory markers based on analysis of the whole blood count. The overall survival rate was 80% for the total follow-up period, while 34 deaths were reported (30-days mortality rate of 1%). In the multivariable analysis, a pre-operative value of systemic inflammatory response index (SIRI) >1.27 (HR = 6.16, 95% CI 2.17–17.48, p = 0.012) revealed a prognostic value for long-term mortality assessment after off-pump surgery. Preoperative inflammatory activation evaluated by systemic inflammatory reaction index (SIRI) possess a prognostic value for patients with complex coronary artery disease. The SIRI value above 1.27 indicates a worse late prognosis after off-pump coronary artery bypass (AUC = 0.682, p<0.001). |
| first_indexed | 2024-04-12T00:51:27Z |
| format | Article |
| id | doaj.art-4b8785b260294daba358029231d8b74e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T00:51:27Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4b8785b260294daba358029231d8b74e2022-12-22T03:54:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-011712Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularizationTomasz UrbanowiczAnna Olasińska-WiśniewskaMichał MichalakBartłomiej PerekAhmed Al-ImamMichał RodzkiAnna WitkowskaEwa Straburzyńska-MigajMichał BociańskiMarcin MisterskiMaciej LesiakMarek JemielityCoronary artery bypass revascularization is still the optimal treatment for complex coronary artery disease with good long-term results. The relation between inflammatory activation in the post-operative period and the long-term prognosis was already postulated. The possible predictive role of preoperative inflammatory indexes after the off-pump coronary artery bypass grafting technique on long term survival was the aim of the study. Study population included 171 patients with a median age of 64 years (59–64) operated on using off-pump technique between January and December 2014. Patients enrolled in the current study were followed-up for 8 years. We conducted a multivariable analysis of pre-operative and post-operative inflammatory markers based on analysis of the whole blood count. The overall survival rate was 80% for the total follow-up period, while 34 deaths were reported (30-days mortality rate of 1%). In the multivariable analysis, a pre-operative value of systemic inflammatory response index (SIRI) >1.27 (HR = 6.16, 95% CI 2.17–17.48, p = 0.012) revealed a prognostic value for long-term mortality assessment after off-pump surgery. Preoperative inflammatory activation evaluated by systemic inflammatory reaction index (SIRI) possess a prognostic value for patients with complex coronary artery disease. The SIRI value above 1.27 indicates a worse late prognosis after off-pump coronary artery bypass (AUC = 0.682, p<0.001).https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754600/?tool=EBI |
| spellingShingle | Tomasz Urbanowicz Anna Olasińska-Wiśniewska Michał Michalak Bartłomiej Perek Ahmed Al-Imam Michał Rodzki Anna Witkowska Ewa Straburzyńska-Migaj Michał Bociański Marcin Misterski Maciej Lesiak Marek Jemielity Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization PLoS ONE |
| title | Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization |
| title_full | Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization |
| title_fullStr | Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization |
| title_full_unstemmed | Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization |
| title_short | Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization |
| title_sort | pre operative systemic inflammatory response index influences long term survival rate in off pump surgical revascularization |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754600/?tool=EBI |
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