Trypanocidal activity of organotin chlorides on Trypanosoma brucei-infected mice
The organotin compounds dibulyltin (DBTC) and diphenyltin dichlorides (DPTC) were tested for trypanocidal activity on a Trypanosoma brucei-infected mice model. At a dose of 10 mg DBTC and 15 mg DPTC/kg/day for five consecutive days, they cleared the parasites from the peripheral blood of the infecte...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2000-03-01
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| Series: | Parasite |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1051/parasite/2000071043 |
| _version_ | 1797423488938541056 |
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| author | Shuaibu M.N. Ameh D.A. Bonire J.J. Adaudi A.O. Ibrahim S. Nok A.J. |
| author_facet | Shuaibu M.N. Ameh D.A. Bonire J.J. Adaudi A.O. Ibrahim S. Nok A.J. |
| author_sort | Shuaibu M.N. |
| collection | DOAJ |
| description | The organotin compounds dibulyltin (DBTC) and diphenyltin dichlorides (DPTC) were tested for trypanocidal activity on a Trypanosoma brucei-infected mice model. At a dose of 10 mg DBTC and 15 mg DPTC/kg/day for five consecutive days, they cleared the parasites from the peripheral blood of the infected mice. Subinoculation of some healthy mice with the homogenates of liver, spleen, kidney, cerebrospinal fluid and blood from the mice considered cured, showed a few cases of relapse. The LD50 of DBTC and DPTC are 90 mg/kg and 75 mg/kg respectively. |
| first_indexed | 2024-03-09T07:48:31Z |
| format | Article |
| id | doaj.art-4b87bd9947184f61aa3da223216c98c8 |
| institution | Directory Open Access Journal |
| issn | 1252-607X 1776-1042 |
| language | English |
| last_indexed | 2024-03-09T07:48:31Z |
| publishDate | 2000-03-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Parasite |
| spelling | doaj.art-4b87bd9947184f61aa3da223216c98c82023-12-03T02:32:03ZengEDP SciencesParasite1252-607X1776-10422000-03-0171434510.1051/parasite/2000071043parasite2000071p43Trypanocidal activity of organotin chlorides on Trypanosoma brucei-infected miceShuaibu M.N.Ameh D.A.Bonire J.J.Adaudi A.O.Ibrahim S.Nok A.J.The organotin compounds dibulyltin (DBTC) and diphenyltin dichlorides (DPTC) were tested for trypanocidal activity on a Trypanosoma brucei-infected mice model. At a dose of 10 mg DBTC and 15 mg DPTC/kg/day for five consecutive days, they cleared the parasites from the peripheral blood of the infected mice. Subinoculation of some healthy mice with the homogenates of liver, spleen, kidney, cerebrospinal fluid and blood from the mice considered cured, showed a few cases of relapse. The LD50 of DBTC and DPTC are 90 mg/kg and 75 mg/kg respectively.http://dx.doi.org/10.1051/parasite/2000071043organotinTrypanosoma brucei bruceitrypanocidal |
| spellingShingle | Shuaibu M.N. Ameh D.A. Bonire J.J. Adaudi A.O. Ibrahim S. Nok A.J. Trypanocidal activity of organotin chlorides on Trypanosoma brucei-infected mice Parasite organotin Trypanosoma brucei brucei trypanocidal |
| title | Trypanocidal activity of organotin chlorides on Trypanosoma brucei-infected mice |
| title_full | Trypanocidal activity of organotin chlorides on Trypanosoma brucei-infected mice |
| title_fullStr | Trypanocidal activity of organotin chlorides on Trypanosoma brucei-infected mice |
| title_full_unstemmed | Trypanocidal activity of organotin chlorides on Trypanosoma brucei-infected mice |
| title_short | Trypanocidal activity of organotin chlorides on Trypanosoma brucei-infected mice |
| title_sort | trypanocidal activity of organotin chlorides on trypanosoma brucei infected mice |
| topic | organotin Trypanosoma brucei brucei trypanocidal |
| url | http://dx.doi.org/10.1051/parasite/2000071043 |
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