Genome-Wide Association Analysis Identifies Important Haplotypes and Candidate Gene <i>XKR4</i> for Body Size Traits in Pekin Ducks
Body size is an important growth indicator in ducks and is a primary selection criterion for physical improvement. An excessively rapid growth rate in meat ducks can result in excessive body size, which may hinder subsequent processing and slaughter operations. However, only a few molecular markers...
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| フォーマット: | 論文 |
| 言語: | English |
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MDPI AG
2024-08-01
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| シリーズ: | Animals |
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| オンライン･アクセス: | https://www.mdpi.com/2076-2615/14/16/2349 |
| _version_ | 1827135457228488704 |
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| author | Jiang-Zhou Yu Jun Zhou Fang-Xi Yang Jin-Ping Hao Zhuo-Cheng Hou Feng Zhu |
| author_facet | Jiang-Zhou Yu Jun Zhou Fang-Xi Yang Jin-Ping Hao Zhuo-Cheng Hou Feng Zhu |
| author_sort | Jiang-Zhou Yu |
| collection | DOAJ |
| description | Body size is an important growth indicator in ducks and is a primary selection criterion for physical improvement. An excessively rapid growth rate in meat ducks can result in excessive body size, which may hinder subsequent processing and slaughter operations. However, only a few molecular markers related to body size have been studied in meat ducks. In this study, we performed a genome-wide association study (GWAS) to identify candidate genes and QTLs affecting body length (BL), keel bone length (KBL), neck length (NL), and breast width (BrW) in Pekin ducks (Anas platyrhynchos domestica). Our results indicate the significant SNP for NL is located within a pseudogene, whereas the significant SNP for BrW is located in an intergenic region. More importantly, our analysis identified a haplotype that was significantly associated with both BL and KBL. This haplotype, containing 48 single-nucleotide polymorphisms (SNPs), is localized within the <i>XKR4</i> gene. The identification of this haplotype suggests that <i>XKR4</i> may be a key candidate gene influencing BL and KBL in Pekin ducks. These findings have important implications for the breeding and genetic improvement of Pekin ducks, and provide valuable insights into the genetic architecture of body size traits in this species. |
| first_indexed | 2025-03-20T17:35:58Z |
| format | Article |
| id | doaj.art-4b88836a76d24872bc9e3b51a8d13e84 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2025-03-20T17:35:58Z |
| publishDate | 2024-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-4b88836a76d24872bc9e3b51a8d13e842024-08-28T14:01:59ZengMDPI AGAnimals2076-26152024-08-011416234910.3390/ani14162349Genome-Wide Association Analysis Identifies Important Haplotypes and Candidate Gene <i>XKR4</i> for Body Size Traits in Pekin DucksJiang-Zhou Yu0Jun Zhou1Fang-Xi Yang2Jin-Ping Hao3Zhuo-Cheng Hou4Feng Zhu5National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaBeijing Nankou Duck Breeding Technology Co., Ltd., Beijing 102202, ChinaBeijing Nankou Duck Breeding Technology Co., Ltd., Beijing 102202, ChinaNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaNational Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breeding and Reproduction of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, ChinaBody size is an important growth indicator in ducks and is a primary selection criterion for physical improvement. An excessively rapid growth rate in meat ducks can result in excessive body size, which may hinder subsequent processing and slaughter operations. However, only a few molecular markers related to body size have been studied in meat ducks. In this study, we performed a genome-wide association study (GWAS) to identify candidate genes and QTLs affecting body length (BL), keel bone length (KBL), neck length (NL), and breast width (BrW) in Pekin ducks (Anas platyrhynchos domestica). Our results indicate the significant SNP for NL is located within a pseudogene, whereas the significant SNP for BrW is located in an intergenic region. More importantly, our analysis identified a haplotype that was significantly associated with both BL and KBL. This haplotype, containing 48 single-nucleotide polymorphisms (SNPs), is localized within the <i>XKR4</i> gene. The identification of this haplotype suggests that <i>XKR4</i> may be a key candidate gene influencing BL and KBL in Pekin ducks. These findings have important implications for the breeding and genetic improvement of Pekin ducks, and provide valuable insights into the genetic architecture of body size traits in this species.https://www.mdpi.com/2076-2615/14/16/2349GWASpekin duckhaplotypebody size |
| spellingShingle | Jiang-Zhou Yu Jun Zhou Fang-Xi Yang Jin-Ping Hao Zhuo-Cheng Hou Feng Zhu Genome-Wide Association Analysis Identifies Important Haplotypes and Candidate Gene <i>XKR4</i> for Body Size Traits in Pekin Ducks Animals GWAS pekin duck haplotype body size |
| title | Genome-Wide Association Analysis Identifies Important Haplotypes and Candidate Gene <i>XKR4</i> for Body Size Traits in Pekin Ducks |
| title_full | Genome-Wide Association Analysis Identifies Important Haplotypes and Candidate Gene <i>XKR4</i> for Body Size Traits in Pekin Ducks |
| title_fullStr | Genome-Wide Association Analysis Identifies Important Haplotypes and Candidate Gene <i>XKR4</i> for Body Size Traits in Pekin Ducks |
| title_full_unstemmed | Genome-Wide Association Analysis Identifies Important Haplotypes and Candidate Gene <i>XKR4</i> for Body Size Traits in Pekin Ducks |
| title_short | Genome-Wide Association Analysis Identifies Important Haplotypes and Candidate Gene <i>XKR4</i> for Body Size Traits in Pekin Ducks |
| title_sort | genome wide association analysis identifies important haplotypes and candidate gene i xkr4 i for body size traits in pekin ducks |
| topic | GWAS pekin duck haplotype body size |
| url | https://www.mdpi.com/2076-2615/14/16/2349 |
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