MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review
Noncoding RNAs (ncRNAs) include a diverse range of RNA species, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). MiRNAs, ncRNAs of approximately 19–25 nucleotides in length, are involved in gene expression regulation either via degradation or silencing of the messenger RNAs (mRNAs) an...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.526850/full |
| _version_ | 1818460660523073536 |
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| author | Simona Ruxandra Volovat Constantin Volovat Constantin Volovat Irina Hordila Dorin-Alexandru Hordila Ciprian Camil Mirestean Oana Tatiana Miron Cristian Lungulescu Dragos Viorel Scripcariu Cati Raluca Stolniceanu Assia Adrianova Konsoulova-Kirova Cristina Grigorescu Cipriana Stefanescu Cristian Constantin Volovat Iolanda Augustin |
| author_facet | Simona Ruxandra Volovat Constantin Volovat Constantin Volovat Irina Hordila Dorin-Alexandru Hordila Ciprian Camil Mirestean Oana Tatiana Miron Cristian Lungulescu Dragos Viorel Scripcariu Cati Raluca Stolniceanu Assia Adrianova Konsoulova-Kirova Cristina Grigorescu Cipriana Stefanescu Cristian Constantin Volovat Iolanda Augustin |
| author_sort | Simona Ruxandra Volovat |
| collection | DOAJ |
| description | Noncoding RNAs (ncRNAs) include a diverse range of RNA species, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). MiRNAs, ncRNAs of approximately 19–25 nucleotides in length, are involved in gene expression regulation either via degradation or silencing of the messenger RNAs (mRNAs) and have roles in multiple biological processes, including cell proliferation, differentiation, migration, angiogenesis, and apoptosis. LncRNAs, which are longer than 200 nucleotides, comprise one of the largest and most heterogeneous RNA families. LncRNAs can activate or repress gene expression through various mechanisms, acting alone or in combination with miRNAs and other molecules as part of various pathways. Until recently, most research has focused on individual lncRNA and miRNA functions as regulators, and there is limited available data on ncRNA interactions relating to the tumor growth, metastasis, and therapy of cancer, acting either on mRNA alone or as competing endogenous RNA (ceRNA) networks. Triple-negative breast cancer (TNBC) represents approximately 10%–20% of all breast cancers (BCs) and is highly heterogenous and more aggressive than other types of BC, for which current targeted treatment options include hormonotherapy, PARP inhibitors, and immunotherapy; however, no targeted therapies for TNBC are available, partly because of a lack of predictive biomarkers. With advances in proteomics, new evidence has emerged demonstrating the implications of dysregulation of ncRNAs in TNBC etiology. Here, we review the roles of lncRNAs and miRNAs implicated in TNBC, including their interactions and regulatory networks. Our synthesis provides insight into the mechanisms involved in TNBC progression and has potential to aid the discovery of new diagnostic and therapeutic strategies. |
| first_indexed | 2024-12-14T23:33:47Z |
| format | Article |
| id | doaj.art-4b8a8e18659b4e7890285736bd521ed0 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-14T23:33:47Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-4b8a8e18659b4e7890285736bd521ed02022-12-21T22:43:39ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-11-011010.3389/fonc.2020.526850526850MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A ReviewSimona Ruxandra Volovat0Constantin Volovat1Constantin Volovat2Irina Hordila3Dorin-Alexandru Hordila4Ciprian Camil Mirestean5Oana Tatiana Miron6Cristian Lungulescu7Dragos Viorel Scripcariu8Cati Raluca Stolniceanu9Assia Adrianova Konsoulova-Kirova10Cristina Grigorescu11Cipriana Stefanescu12Cristian Constantin Volovat13Iolanda Augustin14Department of Medical Oncology-Radiotherapy, Grigore T Popa University of Medicine and Pharmacy, Iași, RomaniaDepartment of Medical Oncology-Radiotherapy, Grigore T Popa University of Medicine and Pharmacy, Iași, RomaniaCenter of Oncology Euroclinic, Iași, RomaniaCenter of Oncology Euroclinic, Iași, RomaniaCenter of Oncology Euroclinic, Iași, RomaniaCenter of Oncology Euroclinic, Iași, RomaniaDepartment of Pneumology, Hospital of Pneumophtysiology, Iasi, RomaniaDepartment of Medical Oncology, University of Medicine and Pharmacy, Craiova, RomaniaDepartment of Surgery, Grigore T Popa University of Medicine and Pharmacy, Iași, RomaniaDepartment of Biophysics and Medical Physics—Nuclear Medicine, University of Medicine and Pharmacy Gr. T. Popa Iasi, Iași, RomaniaDepartment of Medical Oncology, Complex Oncological Center, Burgas, BulgariaDepartment of Surgery, Grigore T Popa University of Medicine and Pharmacy, Iași, RomaniaDepartment of Biophysics and Medical Physics—Nuclear Medicine, University of Medicine and Pharmacy Gr. T. Popa Iasi, Iași, RomaniaDepartment of Radiology, Grigore T Popa University of Medicine and Pharmacy, Iași, RomaniaCenter of Oncology Euroclinic, Iași, RomaniaNoncoding RNAs (ncRNAs) include a diverse range of RNA species, including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). MiRNAs, ncRNAs of approximately 19–25 nucleotides in length, are involved in gene expression regulation either via degradation or silencing of the messenger RNAs (mRNAs) and have roles in multiple biological processes, including cell proliferation, differentiation, migration, angiogenesis, and apoptosis. LncRNAs, which are longer than 200 nucleotides, comprise one of the largest and most heterogeneous RNA families. LncRNAs can activate or repress gene expression through various mechanisms, acting alone or in combination with miRNAs and other molecules as part of various pathways. Until recently, most research has focused on individual lncRNA and miRNA functions as regulators, and there is limited available data on ncRNA interactions relating to the tumor growth, metastasis, and therapy of cancer, acting either on mRNA alone or as competing endogenous RNA (ceRNA) networks. Triple-negative breast cancer (TNBC) represents approximately 10%–20% of all breast cancers (BCs) and is highly heterogenous and more aggressive than other types of BC, for which current targeted treatment options include hormonotherapy, PARP inhibitors, and immunotherapy; however, no targeted therapies for TNBC are available, partly because of a lack of predictive biomarkers. With advances in proteomics, new evidence has emerged demonstrating the implications of dysregulation of ncRNAs in TNBC etiology. Here, we review the roles of lncRNAs and miRNAs implicated in TNBC, including their interactions and regulatory networks. Our synthesis provides insight into the mechanisms involved in TNBC progression and has potential to aid the discovery of new diagnostic and therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fonc.2020.526850/fullmiRNALncRNAbiomarkersceRNAcirculating miRNAtriple negative breast cancer |
| spellingShingle | Simona Ruxandra Volovat Constantin Volovat Constantin Volovat Irina Hordila Dorin-Alexandru Hordila Ciprian Camil Mirestean Oana Tatiana Miron Cristian Lungulescu Dragos Viorel Scripcariu Cati Raluca Stolniceanu Assia Adrianova Konsoulova-Kirova Cristina Grigorescu Cipriana Stefanescu Cristian Constantin Volovat Iolanda Augustin MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review Frontiers in Oncology miRNA LncRNA biomarkers ceRNA circulating miRNA triple negative breast cancer |
| title | MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review |
| title_full | MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review |
| title_fullStr | MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review |
| title_full_unstemmed | MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review |
| title_short | MiRNA and LncRNA as Potential Biomarkers in Triple-Negative Breast Cancer: A Review |
| title_sort | mirna and lncrna as potential biomarkers in triple negative breast cancer a review |
| topic | miRNA LncRNA biomarkers ceRNA circulating miRNA triple negative breast cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.526850/full |
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