The H2-A Class II molecule α/β-chain cis-mismatch severely affects cell surface expression, selection of conventional CD4+ T cells and protection against TB infection

The H2-A Class II molecule α/β-chain cis-mismatch severely affects cell surface expression, selection of conventional CD4+ T cells and protection against TB infection

IntroductionTo dissect the role of the part of the H2 complex comprised of the MHC-II genes in the control of tuberculosis (TB) infection, we previously established a panel of recombinant congenic mouse strains bearing different segments of the H2j haplotype on the B6 (H2b) genetic background. Fine...

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Bibliographic Details
Main Authors: Nadezhda Logunova, Marina Kapina, Elena Kondratieva, Alexander Apt
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
H2-recombinant mice
MHC-II
recombination hot spot
T-cell selection
class II expression
tuberculosis infection
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1183614/full

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