Cuproptosis-associated lncRNAs discern prognosis and immune microenvironment in sarcoma victims
Cuproptosis is a fresh form of the copper-elesclomol-triggered, mitochondrial tricarboxylic acid (TCA) dependent cell death. Yet, the subsumed mechanism of cuproptosis-associated lncRNAs in carcinoma is not wholly clarified. Here, We appraised 580 cuproptosis-associated lncRNAs in sarcoma and therea...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.989882/full |
| _version_ | 1828267130479443968 |
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| author | Binxiang Chu Haihong Zheng Xiaohe Zheng Xingbing Feng Zhenghua Hong |
| author_facet | Binxiang Chu Haihong Zheng Xiaohe Zheng Xingbing Feng Zhenghua Hong |
| author_sort | Binxiang Chu |
| collection | DOAJ |
| description | Cuproptosis is a fresh form of the copper-elesclomol-triggered, mitochondrial tricarboxylic acid (TCA) dependent cell death. Yet, the subsumed mechanism of cuproptosis-associated lncRNAs in carcinoma is not wholly clarified. Here, We appraised 580 cuproptosis-associated lncRNAs in sarcoma and thereafter construed a module composing of 6 cuproptosis lncRNAs, entitled CuLncScore, utilizing a machine learning methodology. It could outstandingly discern the prognosis of patients in parallel with discriminating tumor immune microenvironment traits. Moreover, we simulate the classification system of cuproptosis lncRNAs by unsupervised learning method to facilitate differentiation of clinical denouement and immunotherapy modality options. Notably, Our Taizhou cohort validated the stability of CuLncScore and the classification system. Taking a step further, we checked these 6 cuproptosis lncRNAs by Quantitative real-time polymerase chain reaction (qRT-PCR) to ascertain their authenticity. All told, our investigations highlight that cuproptosis lncRNAs are involved in various components of sarcoma and assist in the formation of the tumor immune microenvironment. These results provide partial insights to further comprehend the molecular mechanisms of cuproptosis lncRNAs in sarcoma and could be helpful for the development of personalized therapeutic strategies targeting cuproptosis or cuproptosis lncRNAs. |
| first_indexed | 2024-04-13T05:01:38Z |
| format | Article |
| id | doaj.art-4b8d6944792c45579b76f474edd537c7 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-13T05:01:38Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-4b8d6944792c45579b76f474edd537c72022-12-22T03:01:19ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-12-011010.3389/fcell.2022.989882989882Cuproptosis-associated lncRNAs discern prognosis and immune microenvironment in sarcoma victimsBinxiang Chu0Haihong Zheng1Xiaohe Zheng2Xingbing Feng3Zhenghua Hong4Department of Orthopedic, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, ChinaDepartment of Pathology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, ChinaDepartment of Pathology, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, ChinaDepartment of Orthopedic, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, ChinaDepartment of Orthopedic, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, ChinaCuproptosis is a fresh form of the copper-elesclomol-triggered, mitochondrial tricarboxylic acid (TCA) dependent cell death. Yet, the subsumed mechanism of cuproptosis-associated lncRNAs in carcinoma is not wholly clarified. Here, We appraised 580 cuproptosis-associated lncRNAs in sarcoma and thereafter construed a module composing of 6 cuproptosis lncRNAs, entitled CuLncScore, utilizing a machine learning methodology. It could outstandingly discern the prognosis of patients in parallel with discriminating tumor immune microenvironment traits. Moreover, we simulate the classification system of cuproptosis lncRNAs by unsupervised learning method to facilitate differentiation of clinical denouement and immunotherapy modality options. Notably, Our Taizhou cohort validated the stability of CuLncScore and the classification system. Taking a step further, we checked these 6 cuproptosis lncRNAs by Quantitative real-time polymerase chain reaction (qRT-PCR) to ascertain their authenticity. All told, our investigations highlight that cuproptosis lncRNAs are involved in various components of sarcoma and assist in the formation of the tumor immune microenvironment. These results provide partial insights to further comprehend the molecular mechanisms of cuproptosis lncRNAs in sarcoma and could be helpful for the development of personalized therapeutic strategies targeting cuproptosis or cuproptosis lncRNAs.https://www.frontiersin.org/articles/10.3389/fcell.2022.989882/fullcuproptosislncRNAsarcomatumor immune microenvironmentimmunotherapyprognosis |
| spellingShingle | Binxiang Chu Haihong Zheng Xiaohe Zheng Xingbing Feng Zhenghua Hong Cuproptosis-associated lncRNAs discern prognosis and immune microenvironment in sarcoma victims Frontiers in Cell and Developmental Biology cuproptosis lncRNA sarcoma tumor immune microenvironment immunotherapy prognosis |
| title | Cuproptosis-associated lncRNAs discern prognosis and immune microenvironment in sarcoma victims |
| title_full | Cuproptosis-associated lncRNAs discern prognosis and immune microenvironment in sarcoma victims |
| title_fullStr | Cuproptosis-associated lncRNAs discern prognosis and immune microenvironment in sarcoma victims |
| title_full_unstemmed | Cuproptosis-associated lncRNAs discern prognosis and immune microenvironment in sarcoma victims |
| title_short | Cuproptosis-associated lncRNAs discern prognosis and immune microenvironment in sarcoma victims |
| title_sort | cuproptosis associated lncrnas discern prognosis and immune microenvironment in sarcoma victims |
| topic | cuproptosis lncRNA sarcoma tumor immune microenvironment immunotherapy prognosis |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.989882/full |
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