Efferent therapy in the first-line drug treatment of metastatic colorectal cancer
The aim of this study is to analyse the efficacy of efferent therapy (hemosorption) as part of drug treatment in patients with metastatic colorectal cancer (mCRC) based on the use of standard first-line chemotherapy combined with the bevacizumab biosimilar. The study included 54 patients with histol...
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| Format: | Article |
| Language: | Russian |
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Remedium Group LLC
2018-07-01
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| Series: | Медицинский совет |
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| Online Access: | https://www.med-sovet.pro/jour/article/view/2554 |
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| author | Z. S. Kotova T. Yu. Semiglazova I. A. Baldueva D. H. Latipova D. O. Yurlov V. V. Semiglazov G. M. Teletaeva A. V. Novik A. I. Semenova S. A. Protsenko |
| author_facet | Z. S. Kotova T. Yu. Semiglazova I. A. Baldueva D. H. Latipova D. O. Yurlov V. V. Semiglazov G. M. Teletaeva A. V. Novik A. I. Semenova S. A. Protsenko |
| author_sort | Z. S. Kotova |
| collection | DOAJ |
| description | The aim of this study is to analyse the efficacy of efferent therapy (hemosorption) as part of drug treatment in patients with metastatic colorectal cancer (mCRC) based on the use of standard first-line chemotherapy combined with the bevacizumab biosimilar. The study included 54 patients with histologically verified mCRC who received the first-line FOLFOX + bevacizumab therapy in combination with and without hemosorption. All patients of the FOLFOX + bevacizumab (+) hemosorption group (n = 32) received the hemosorption using Hemophoenix apparatus on Day 4 of the cycle during the first 6 cycles. A total of 182 hemosorption procedures were performed. The control group included 22 patients receiving the FOLFOX + bevacizumab regimen without hemosorption. The bevacizumab biosimilar was introduced in both groups throughout the treatment at standard doses once every 2 weeks. There was no statistically significant difference between the study groups in the main clinical, pathomorphological, molecular genetic characteristics (sex, age, ECOG status, localization of primary tumor, tumor differentiation, RAS, BRAF mutations, microsatellite instability, etc.).Blood sampling to evaluate the effect of hemosorption on the pharmacokinetics (PK) of bevacizumab biosimilar was performed during the 2nd cycle before (PK1) and after (PK2) hemosorption procedures. The bevacizumab biosimilar concentration in the blood of patients before and after hemosorption showed no statistically significant difference (p = 0,423).The use of pharmaceutical treatment in the FOLFOX + bevacizumab (+) hemosorption group contributed to the achievement of an objective response (OR) in 62% of patients (p = 0.001). Median progression-free survival (PFS) was 10 ± 0.9 months [95% CI 8.3-11.7] in the FOLFOX + bevacizumab (+) hemosorption group, and 7 ± 0.5 months [95% CI 4.4-11.6] in the FOLFOX + bevacizumab (-) hemosorption group. There was no significant difference in PFS between the groups of patients treated with FOLFOX + bevacizumab regimen with and without hemosorption (p = 0.445).There were statistically significant differences in the frequency of nausea, diarrhoea and asthenia in the FOLFOX + bevacizumab (+) hemosorption group. The analysis of the dynamics of the quality of life (QoL) level before and after treatment showed that QoL level related to health (p = 0.0001) as well as the emotional (p = 0.0001) and social (p = 0,04) functioning increased in patients receiving the FOLFOX + bevacizumab regimen in combination with hemosorption, 0,039).Thus, the addition of hemosorption to the first-line drug treatment according to the FOLFOX + bevacizumab regimen does not affect bevacizumab pharmacokinetics, increases the frequency of objective response, reduces toxicity of the therapy and improves the quality of patients’ life indicators. |
| first_indexed | 2024-04-09T16:28:26Z |
| format | Article |
| id | doaj.art-4b8d8806db7444a88919e0781d762df9 |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:28:26Z |
| publishDate | 2018-07-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-4b8d8806db7444a88919e0781d762df92023-04-23T06:57:11ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902018-07-0101017217510.21518/2079-701X-2018-10-172-1752515Efferent therapy in the first-line drug treatment of metastatic colorectal cancerZ. S. Kotova0T. Yu. Semiglazova1I. A. Baldueva2D. H. Latipova3D. O. Yurlov4V. V. Semiglazov5G. M. Teletaeva6A. V. Novik7A. I. Semenova8S. A. Protsenko9Petrov Russian Research Centre of Oncology of the Ministry of Health of RussiaPetrov Russian Research Centre of Oncology of the Ministry of Health of Russia; Mechnikov North-Western State Medical University of the Ministry of Health of RussiaPetrov Russian Research Centre of Oncology of the Ministry of Health of Russia; Mechnikov North-Western State Medical University of the Ministry of Health of RussiaPetrov Russian Research Centre of Oncology of the Ministry of Health of RussiaPetrov Russian Research Centre of Oncology of the Ministry of Health of RussiaPetrov Russian Research Centre of Oncology of the Ministry of Health of Russia; Pavlov First Saint Petersburg State Medical University of the Ministry of Health of RussiaPetrov Russian Research Centre of Oncology of the Ministry of Health of RussiaPetrov Russian Research Centre of Oncology of the Ministry of Health of Russia; Mechnikov North-Western State Medical University of the Ministry of Health of RussiaPetrov Russian Research Centre of Oncology of the Ministry of Health of RussiaPetrov Russian Research Centre of Oncology of the Ministry of Health of RussiaThe aim of this study is to analyse the efficacy of efferent therapy (hemosorption) as part of drug treatment in patients with metastatic colorectal cancer (mCRC) based on the use of standard first-line chemotherapy combined with the bevacizumab biosimilar. The study included 54 patients with histologically verified mCRC who received the first-line FOLFOX + bevacizumab therapy in combination with and without hemosorption. All patients of the FOLFOX + bevacizumab (+) hemosorption group (n = 32) received the hemosorption using Hemophoenix apparatus on Day 4 of the cycle during the first 6 cycles. A total of 182 hemosorption procedures were performed. The control group included 22 patients receiving the FOLFOX + bevacizumab regimen without hemosorption. The bevacizumab biosimilar was introduced in both groups throughout the treatment at standard doses once every 2 weeks. There was no statistically significant difference between the study groups in the main clinical, pathomorphological, molecular genetic characteristics (sex, age, ECOG status, localization of primary tumor, tumor differentiation, RAS, BRAF mutations, microsatellite instability, etc.).Blood sampling to evaluate the effect of hemosorption on the pharmacokinetics (PK) of bevacizumab biosimilar was performed during the 2nd cycle before (PK1) and after (PK2) hemosorption procedures. The bevacizumab biosimilar concentration in the blood of patients before and after hemosorption showed no statistically significant difference (p = 0,423).The use of pharmaceutical treatment in the FOLFOX + bevacizumab (+) hemosorption group contributed to the achievement of an objective response (OR) in 62% of patients (p = 0.001). Median progression-free survival (PFS) was 10 ± 0.9 months [95% CI 8.3-11.7] in the FOLFOX + bevacizumab (+) hemosorption group, and 7 ± 0.5 months [95% CI 4.4-11.6] in the FOLFOX + bevacizumab (-) hemosorption group. There was no significant difference in PFS between the groups of patients treated with FOLFOX + bevacizumab regimen with and without hemosorption (p = 0.445).There were statistically significant differences in the frequency of nausea, diarrhoea and asthenia in the FOLFOX + bevacizumab (+) hemosorption group. The analysis of the dynamics of the quality of life (QoL) level before and after treatment showed that QoL level related to health (p = 0.0001) as well as the emotional (p = 0.0001) and social (p = 0,04) functioning increased in patients receiving the FOLFOX + bevacizumab regimen in combination with hemosorption, 0,039).Thus, the addition of hemosorption to the first-line drug treatment according to the FOLFOX + bevacizumab regimen does not affect bevacizumab pharmacokinetics, increases the frequency of objective response, reduces toxicity of the therapy and improves the quality of patients’ life indicators.https://www.med-sovet.pro/jour/article/view/2554metastatic colorectal cancerhemosorptionbevacizumab biosimilarfirst-line treatment |
| spellingShingle | Z. S. Kotova T. Yu. Semiglazova I. A. Baldueva D. H. Latipova D. O. Yurlov V. V. Semiglazov G. M. Teletaeva A. V. Novik A. I. Semenova S. A. Protsenko Efferent therapy in the first-line drug treatment of metastatic colorectal cancer Медицинский совет metastatic colorectal cancer hemosorption bevacizumab biosimilar first-line treatment |
| title | Efferent therapy in the first-line drug treatment of metastatic colorectal cancer |
| title_full | Efferent therapy in the first-line drug treatment of metastatic colorectal cancer |
| title_fullStr | Efferent therapy in the first-line drug treatment of metastatic colorectal cancer |
| title_full_unstemmed | Efferent therapy in the first-line drug treatment of metastatic colorectal cancer |
| title_short | Efferent therapy in the first-line drug treatment of metastatic colorectal cancer |
| title_sort | efferent therapy in the first line drug treatment of metastatic colorectal cancer |
| topic | metastatic colorectal cancer hemosorption bevacizumab biosimilar first-line treatment |
| url | https://www.med-sovet.pro/jour/article/view/2554 |
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