Activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test: An fMRI approach
<p>Abstract</p> <p>Background</p> <p>The <it>Kana Pick-out Test</it> (KPT), which uses <it>Kana or</it> Japanese symbols that represent syllables, requires parallel processing of discrete (pick-out) and continuous (reading) dual tasks. As a dual...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-05-01
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| Series: | Behavioral and Brain Functions |
| Subjects: | |
| Online Access: | http://www.behavioralandbrainfunctions.com/content/8/1/26 |
| _version_ | 1824020064565723136 |
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| author | Tachibana Atsumichi Noah J Bronner Shaw Ono Yumie Hirano Yoshiyuki Niwa Masami Watanabe Kazuko Onozuka Minoru |
| author_facet | Tachibana Atsumichi Noah J Bronner Shaw Ono Yumie Hirano Yoshiyuki Niwa Masami Watanabe Kazuko Onozuka Minoru |
| author_sort | Tachibana Atsumichi |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The <it>Kana Pick-out Test</it> (KPT), which uses <it>Kana or</it> Japanese symbols that represent syllables, requires parallel processing of discrete (pick-out) and continuous (reading) dual tasks. As a dual task, the KPT is thought to test working memory and executive function, particularly in the prefrontal cortex (PFC), and is widely used in Japan as a clinical screen for dementia. Nevertheless, there has been little neurological investigation into PFC activity during this test.</p> <p>Methods</p> <p>We used functional magnetic resonance imaging (fMRI) to evaluate changes in the blood oxygenation level-dependent (BOLD) signal in young healthy adults during performance of a computerized KPT dual task (comprised of reading comprehension and picking out vowels) and compared it to its single task components (reading or vowel pick-out alone).</p> <p>Results</p> <p>Behavioral performance of the KPT degraded compared to its single task components. Performance of the KPT markedly increased BOLD signal intensity in the PFC, and also activated sensorimotor, parietal association, and visual cortex areas. In conjunction analyses, bilateral BOLD signal in the dorsolateral PFC (Brodmann's areas 45, 46) was present only in the KPT.</p> <p>Conclusions</p> <p>Our results support the central bottleneck theory and suggest that the dorsolateral PFC is an important mediator of neural activity for both short-term storage and executive processes. Quantitative evaluation of the KPT with fMRI in healthy adults is the first step towards understanding the effects of aging or cognitive impairment on KPT performance.</p> |
| first_indexed | 2024-12-19T01:27:23Z |
| format | Article |
| id | doaj.art-4b8f73a8a3a74069a0cd56c9265ec75f |
| institution | Directory Open Access Journal |
| issn | 1744-9081 |
| language | English |
| last_indexed | 2024-12-19T01:27:23Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Behavioral and Brain Functions |
| spelling | doaj.art-4b8f73a8a3a74069a0cd56c9265ec75f2022-12-21T20:42:12ZengBMCBehavioral and Brain Functions1744-90812012-05-01812610.1186/1744-9081-8-26Activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test: An fMRI approachTachibana AtsumichiNoah JBronner ShawOno YumieHirano YoshiyukiNiwa MasamiWatanabe KazukoOnozuka Minoru<p>Abstract</p> <p>Background</p> <p>The <it>Kana Pick-out Test</it> (KPT), which uses <it>Kana or</it> Japanese symbols that represent syllables, requires parallel processing of discrete (pick-out) and continuous (reading) dual tasks. As a dual task, the KPT is thought to test working memory and executive function, particularly in the prefrontal cortex (PFC), and is widely used in Japan as a clinical screen for dementia. Nevertheless, there has been little neurological investigation into PFC activity during this test.</p> <p>Methods</p> <p>We used functional magnetic resonance imaging (fMRI) to evaluate changes in the blood oxygenation level-dependent (BOLD) signal in young healthy adults during performance of a computerized KPT dual task (comprised of reading comprehension and picking out vowels) and compared it to its single task components (reading or vowel pick-out alone).</p> <p>Results</p> <p>Behavioral performance of the KPT degraded compared to its single task components. Performance of the KPT markedly increased BOLD signal intensity in the PFC, and also activated sensorimotor, parietal association, and visual cortex areas. In conjunction analyses, bilateral BOLD signal in the dorsolateral PFC (Brodmann's areas 45, 46) was present only in the KPT.</p> <p>Conclusions</p> <p>Our results support the central bottleneck theory and suggest that the dorsolateral PFC is an important mediator of neural activity for both short-term storage and executive processes. Quantitative evaluation of the KPT with fMRI in healthy adults is the first step towards understanding the effects of aging or cognitive impairment on KPT performance.</p>http://www.behavioralandbrainfunctions.com/content/8/1/26Executive functionNeuropsychological testWorking memory |
| spellingShingle | Tachibana Atsumichi Noah J Bronner Shaw Ono Yumie Hirano Yoshiyuki Niwa Masami Watanabe Kazuko Onozuka Minoru Activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test: An fMRI approach Behavioral and Brain Functions Executive function Neuropsychological test Working memory |
| title | Activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test: An fMRI approach |
| title_full | Activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test: An fMRI approach |
| title_fullStr | Activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test: An fMRI approach |
| title_full_unstemmed | Activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test: An fMRI approach |
| title_short | Activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test: An fMRI approach |
| title_sort | activation of dorsolateral prefrontal cortex in a dual neuropsychological screening test an fmri approach |
| topic | Executive function Neuropsychological test Working memory |
| url | http://www.behavioralandbrainfunctions.com/content/8/1/26 |
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