Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicities
Heavy metals are the metal compounds found in earth’s crust and have densities higher than that of water. Common heavy metals include the lead, arsenic, mercury, cadmium, copper, manganese, chromium, nickel, and aluminum. Their environmental levels are consistently rising above the permissible limit...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1218497/full |
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| author | Muhammad Sajid Hamid Akash Azka Yaqoob Kanwal Rehman Muhammad Imran Muhammad Imran Mohammed A. Assiri Mohammed A. Assiri Fatema Al-Rashed Fahd Al-Mulla Rasheed Ahmad Sardar Sindhu Sardar Sindhu |
| author_facet | Muhammad Sajid Hamid Akash Azka Yaqoob Kanwal Rehman Muhammad Imran Muhammad Imran Mohammed A. Assiri Mohammed A. Assiri Fatema Al-Rashed Fahd Al-Mulla Rasheed Ahmad Sardar Sindhu Sardar Sindhu |
| author_sort | Muhammad Sajid Hamid Akash |
| collection | DOAJ |
| description | Heavy metals are the metal compounds found in earth’s crust and have densities higher than that of water. Common heavy metals include the lead, arsenic, mercury, cadmium, copper, manganese, chromium, nickel, and aluminum. Their environmental levels are consistently rising above the permissible limits and they are highly toxic as enter living systems via inhalation, ingestion, or inoculation. Prolonged exposures cause the disruption of metabolism, altered gene and/or protein expression, and dysregulated metabolite profiles. Metabolomics is a state of the art analytical tool widely used for pathomolecular inv22estigations, biomarkers, drug discovery and validation of biotransformation pathways in the fields of biomedicine, nutrition, agriculture, and industry. Here, we overview studies using metabolomics as a dynamic tool to decipher the mechanisms of metabolic impairment related to heavy metal toxicities caused by the environmental or experimental exposures in different living systems. These investigations highlight the key role of metabolomics in identifying perturbations in pathways of lipid and amino acid metabolism, with a critical role of oxidative stress in metabolic impairment. We present the conclusions with future perspectives on metabolomics applications in meeting emerging needs. |
| first_indexed | 2024-03-13T01:01:58Z |
| format | Article |
| id | doaj.art-4b90f70d640a498a96a7f9bd06474d01 |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2024-03-13T01:01:58Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-4b90f70d640a498a96a7f9bd06474d012023-07-06T11:16:44ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-07-011010.3389/fmolb.2023.12184971218497Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicitiesMuhammad Sajid Hamid Akash0Azka Yaqoob1Kanwal Rehman2Muhammad Imran3Muhammad Imran4Mohammed A. Assiri5Mohammed A. Assiri6Fatema Al-Rashed7Fahd Al-Mulla8Rasheed Ahmad9Sardar Sindhu10Sardar Sindhu11Department of Pharmaceutical Chemistry, Government College University Faisalabad, Faisalabad, PakistanDepartment of Pharmaceutical Chemistry, Government College University Faisalabad, Faisalabad, PakistanDepartment of Pharmacy, The Women University, Multan, PakistanResearch Center for Advanced Materials Science (RCAMS), King Khalid University, Abha, Saudi ArabiaDepartment of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi ArabiaResearch Center for Advanced Materials Science (RCAMS), King Khalid University, Abha, Saudi ArabiaDepartment of Chemistry, Faculty of Science, King Khalid University, Abha, Saudi ArabiaImmunology and Microbiology Department, Dasman Diabetes Institute, Dasman, KuwaitResearch Division, Dasman Diabetes Institute, Dasman, KuwaitImmunology and Microbiology Department, Dasman Diabetes Institute, Dasman, KuwaitImmunology and Microbiology Department, Dasman Diabetes Institute, Dasman, KuwaitAnimal and Imaging Core Facilities, Dasman Diabetes Institute, Dasman, KuwaitHeavy metals are the metal compounds found in earth’s crust and have densities higher than that of water. Common heavy metals include the lead, arsenic, mercury, cadmium, copper, manganese, chromium, nickel, and aluminum. Their environmental levels are consistently rising above the permissible limits and they are highly toxic as enter living systems via inhalation, ingestion, or inoculation. Prolonged exposures cause the disruption of metabolism, altered gene and/or protein expression, and dysregulated metabolite profiles. Metabolomics is a state of the art analytical tool widely used for pathomolecular inv22estigations, biomarkers, drug discovery and validation of biotransformation pathways in the fields of biomedicine, nutrition, agriculture, and industry. Here, we overview studies using metabolomics as a dynamic tool to decipher the mechanisms of metabolic impairment related to heavy metal toxicities caused by the environmental or experimental exposures in different living systems. These investigations highlight the key role of metabolomics in identifying perturbations in pathways of lipid and amino acid metabolism, with a critical role of oxidative stress in metabolic impairment. We present the conclusions with future perspectives on metabolomics applications in meeting emerging needs.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1218497/fullheavy metalstoxicitymetabolomicsmetabolic impairmentoxidative stress |
| spellingShingle | Muhammad Sajid Hamid Akash Azka Yaqoob Kanwal Rehman Muhammad Imran Muhammad Imran Mohammed A. Assiri Mohammed A. Assiri Fatema Al-Rashed Fahd Al-Mulla Rasheed Ahmad Sardar Sindhu Sardar Sindhu Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicities Frontiers in Molecular Biosciences heavy metals toxicity metabolomics metabolic impairment oxidative stress |
| title | Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicities |
| title_full | Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicities |
| title_fullStr | Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicities |
| title_full_unstemmed | Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicities |
| title_short | Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicities |
| title_sort | metabolomics a promising tool for deciphering metabolic impairment in heavy metal toxicities |
| topic | heavy metals toxicity metabolomics metabolic impairment oxidative stress |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1218497/full |
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