Inhibition of non-canonical NF-κB signaling suppresses periodontal inflammation and bone loss

Inhibition of non-canonical NF-κB signaling suppresses periodontal inflammation and bone loss

Periodontal disease is an infectious disease that affects many people worldwide. Disease progression destroys the alveolar bone and causes tooth loss. We have previously shown that alymphoplasia (aly/aly) mice harboring a loss-of-function mutation in the map3k14 gene, which is involved in p100 to p5...

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Bibliographic Details
Main Authors: Tsukasa Aoki, Fumitaka Hiura, Aonan Li, Nan Yang, Nana Takakura-Hino, Satoru Mukai, Miho Matsuda, Fusanori Nishimura, Eijiro Jimi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Immunology
Subjects:
nuclear factor-k B
periodonititis
osteoclasts (OCs)
inflammation
bone
NIK
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1179007/full

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