Selection dynamics of HCV genotype 3 resistance-associated substitutions under direct-acting antiviral therapy pressure

Selection dynamics of HCV genotype 3 resistance-associated substitutions under direct-acting antiviral therapy pressure

The chronic hepatitis C (CHC) treatment is currently based on the use of direct-acting antivirals (DAAs), and patients infected with hepatitis C virus genotype 3 (GT3) have emerged as a more difficult-to-cure population. The NS5A inhibitor daclatasvir (DCV) and sofosbuvir (SOF), an NS5B viral polyme...

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Bibliographic Details
Main Authors: João Paulo Vilela Rodrigues, Guilherme Rodrigues Fernandes Campos, Cintia Bittar, Ana de Lourdes Candolo Martinelli, Marília Silveira de Almeida Campos, Leonardo Régis Leira Pereira, Paula Rahal, Fernanda Fernandes Souza
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Brazilian Journal of Infectious Diseases
Subjects:
Hepatitis C, Chronic
Hepacivirus
Antiviral agents
Drug resistance, Viral
Online Access:http://www.sciencedirect.com/science/article/pii/S141386702200410X

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