MET Expression Level in Lung Adenocarcinoma Loosely Correlates with <i>MET</i> Copy Number Gain/Amplification and Is a Poor Predictor of Patient Outcome
<i>MET</i> amplification has been associated with shorter survival in cancer patients, however, the potential correlation of MET overexpression with either <i>MET</i> amplification or patient outcome is controversial. The aim of this study was to address these questions by co...
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MDPI AG
2022-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/10/2433 |
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| author | Wei Yin Ming Guo Zhenya Tang Gokce A. Toruner Joanne Cheng L. Jeffrey Medeiros Guilin Tang |
| author_facet | Wei Yin Ming Guo Zhenya Tang Gokce A. Toruner Joanne Cheng L. Jeffrey Medeiros Guilin Tang |
| author_sort | Wei Yin |
| collection | DOAJ |
| description | <i>MET</i> amplification has been associated with shorter survival in cancer patients, however, the potential correlation of MET overexpression with either <i>MET</i> amplification or patient outcome is controversial. The aim of this study was to address these questions by correlating MET expression level with <i>MET</i> copy number and patient outcome in a cohort of 446 patients who had a lung adenocarcinoma: 88 with <i>MET</i> amplification, 118 with polysomy 7, and 240 with negative results by fluorescence in situ hybridization. MET expression assessed by immunohistochemistry was semi-quantified by expression level: absent (0+), weak (1+), moderate (2+) and strong (3+); or by H-score: 0–99, 100–199, and ≥200. MET expression level or H-score was positively but weakly correlated with <i>MET</i> copy number or <i>MET/CEP7</i> ratio. Strong expression of MET (3+ or H-score ≥ 200) was associated with a shorter overall survival, but it was not an independent hazard for survival by multivariant analysis. We conclude that MET expression is loosely correlated with MET copy number gain/amplification. Strong expression of MET does not independently predict patient outcome. |
| first_indexed | 2024-03-10T03:12:31Z |
| format | Article |
| id | doaj.art-4b953f8699144dcbb100feffbdc895e3 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T03:12:31Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-4b953f8699144dcbb100feffbdc895e32023-11-23T10:23:05ZengMDPI AGCancers2072-66942022-05-011410243310.3390/cancers14102433MET Expression Level in Lung Adenocarcinoma Loosely Correlates with <i>MET</i> Copy Number Gain/Amplification and Is a Poor Predictor of Patient OutcomeWei Yin0Ming Guo1Zhenya Tang2Gokce A. Toruner3Joanne Cheng4L. Jeffrey Medeiros5Guilin Tang6Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USADepartment of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA<i>MET</i> amplification has been associated with shorter survival in cancer patients, however, the potential correlation of MET overexpression with either <i>MET</i> amplification or patient outcome is controversial. The aim of this study was to address these questions by correlating MET expression level with <i>MET</i> copy number and patient outcome in a cohort of 446 patients who had a lung adenocarcinoma: 88 with <i>MET</i> amplification, 118 with polysomy 7, and 240 with negative results by fluorescence in situ hybridization. MET expression assessed by immunohistochemistry was semi-quantified by expression level: absent (0+), weak (1+), moderate (2+) and strong (3+); or by H-score: 0–99, 100–199, and ≥200. MET expression level or H-score was positively but weakly correlated with <i>MET</i> copy number or <i>MET/CEP7</i> ratio. Strong expression of MET (3+ or H-score ≥ 200) was associated with a shorter overall survival, but it was not an independent hazard for survival by multivariant analysis. We conclude that MET expression is loosely correlated with MET copy number gain/amplification. Strong expression of MET does not independently predict patient outcome.https://www.mdpi.com/2072-6694/14/10/2433MET expression<i>MET</i> amplificationlung cancersurvival |
| spellingShingle | Wei Yin Ming Guo Zhenya Tang Gokce A. Toruner Joanne Cheng L. Jeffrey Medeiros Guilin Tang MET Expression Level in Lung Adenocarcinoma Loosely Correlates with <i>MET</i> Copy Number Gain/Amplification and Is a Poor Predictor of Patient Outcome Cancers MET expression <i>MET</i> amplification lung cancer survival |
| title | MET Expression Level in Lung Adenocarcinoma Loosely Correlates with <i>MET</i> Copy Number Gain/Amplification and Is a Poor Predictor of Patient Outcome |
| title_full | MET Expression Level in Lung Adenocarcinoma Loosely Correlates with <i>MET</i> Copy Number Gain/Amplification and Is a Poor Predictor of Patient Outcome |
| title_fullStr | MET Expression Level in Lung Adenocarcinoma Loosely Correlates with <i>MET</i> Copy Number Gain/Amplification and Is a Poor Predictor of Patient Outcome |
| title_full_unstemmed | MET Expression Level in Lung Adenocarcinoma Loosely Correlates with <i>MET</i> Copy Number Gain/Amplification and Is a Poor Predictor of Patient Outcome |
| title_short | MET Expression Level in Lung Adenocarcinoma Loosely Correlates with <i>MET</i> Copy Number Gain/Amplification and Is a Poor Predictor of Patient Outcome |
| title_sort | met expression level in lung adenocarcinoma loosely correlates with i met i copy number gain amplification and is a poor predictor of patient outcome |
| topic | MET expression <i>MET</i> amplification lung cancer survival |
| url | https://www.mdpi.com/2072-6694/14/10/2433 |
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