Fat-soluble vitamin deficiencies after bariatric surgery could be misleading if they are not appropriately adjusted
Objective: To evaluate the differences in frequency of fat-soluble vitamin deficiencies if we adjust their levels by its main carriers in plasma in patients undergoing Biliopancreatic diversion (BPD) and Roux-en-Y gastric bypass (RYGB). Research Methods & Procedures: We recruited 178 patients wh...
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| Format: | Article |
| Language: | English |
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Arán Ediciones, S. L.
2014-07-01
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| Series: | Nutrición Hospitalaria |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014000800015&lng=en&tlng=en |
| _version_ | 1818480406054305792 |
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| author | Martín Cuesta Laura Pelaz Celia Pérez M.ª José Torrejón Lucio Cabrerizo Pilar Matía Natalia Pérez-Ferre Andrés Sánchez-Pernaute Antonio Torres Miguel A. Rubio |
| author_facet | Martín Cuesta Laura Pelaz Celia Pérez M.ª José Torrejón Lucio Cabrerizo Pilar Matía Natalia Pérez-Ferre Andrés Sánchez-Pernaute Antonio Torres Miguel A. Rubio |
| author_sort | Martín Cuesta |
| collection | DOAJ |
| description | Objective: To evaluate the differences in frequency of fat-soluble vitamin deficiencies if we adjust their levels by its main carriers in plasma in patients undergoing Biliopancreatic diversion (BPD) and Roux-en-Y gastric bypass (RYGB). Research Methods & Procedures: We recruited 178 patients who underwent RYGB (n = 116 patients) and BPD (n = 62 patients) in a single centre. Basal data information and one-year after surgery included: anthropometric measurements, fat-soluble vitamins A, E and D, retinol binding protein (RBP) and total cholesterol as carriers of vitamin A and E respectively. Continuous data were compared using T-Student and proportions using chi-square test. Results: There was a vitamin D deficiency of 96% of all patients, 10% vitamin A deficiency and 1.2% vitamin E deficiency prior to surgery. One year after surgery, 33% of patients were vitamin A deficient but the frequency reduced to 19% when we adjusted by RBP. We found a vitamin E deficiency frequency of 0% in RYGB and 4.8% in DBP one year after surgery. However, when we adjusted the serum levels to total cholesterol, we found an increased frequency of 8.7% in RYGB group for vitamin E deficiency and 21.4% in DBP (p = 0.04). Conclusion: We have found a different frequency of deficit for fat-soluble vitamin both in BPD and RYGB once we have adjusted for its main carriers. This is clinically relevant to prevent from overexposure and toxicity. We suggest that carrier molecules should be routinely requested when we assess fat-soluble vitamin status in patients who undergo malabsorptive procedures. |
| first_indexed | 2024-12-10T11:23:10Z |
| format | Article |
| id | doaj.art-4b993882a8854621b5512a0df2157c31 |
| institution | Directory Open Access Journal |
| issn | 0212-1611 |
| language | English |
| last_indexed | 2024-12-10T11:23:10Z |
| publishDate | 2014-07-01 |
| publisher | Arán Ediciones, S. L. |
| record_format | Article |
| series | Nutrición Hospitalaria |
| spelling | doaj.art-4b993882a8854621b5512a0df2157c312022-12-22T01:50:51ZengArán Ediciones, S. L.Nutrición Hospitalaria0212-16112014-07-0130111812310.3305/nh.2014.30.1.7471S0212-16112014000800015Fat-soluble vitamin deficiencies after bariatric surgery could be misleading if they are not appropriately adjustedMartín Cuesta0Laura Pelaz1Celia Pérez2M.ª José Torrejón3Lucio Cabrerizo4Pilar Matía5Natalia Pérez-Ferre6Andrés Sánchez-Pernaute7Antonio Torres8Miguel A. Rubio9Hospital Clínico San CarlosHospital Clínico San CarlosHospital Clínico San CarlosHospital Clínico San CarlosHospital Clínico San CarlosHospital Clínico San CarlosHospital Clínico San CarlosHospital Clínico San CarlosHospital Clínico San CarlosHospital Clínico San CarlosObjective: To evaluate the differences in frequency of fat-soluble vitamin deficiencies if we adjust their levels by its main carriers in plasma in patients undergoing Biliopancreatic diversion (BPD) and Roux-en-Y gastric bypass (RYGB). Research Methods & Procedures: We recruited 178 patients who underwent RYGB (n = 116 patients) and BPD (n = 62 patients) in a single centre. Basal data information and one-year after surgery included: anthropometric measurements, fat-soluble vitamins A, E and D, retinol binding protein (RBP) and total cholesterol as carriers of vitamin A and E respectively. Continuous data were compared using T-Student and proportions using chi-square test. Results: There was a vitamin D deficiency of 96% of all patients, 10% vitamin A deficiency and 1.2% vitamin E deficiency prior to surgery. One year after surgery, 33% of patients were vitamin A deficient but the frequency reduced to 19% when we adjusted by RBP. We found a vitamin E deficiency frequency of 0% in RYGB and 4.8% in DBP one year after surgery. However, when we adjusted the serum levels to total cholesterol, we found an increased frequency of 8.7% in RYGB group for vitamin E deficiency and 21.4% in DBP (p = 0.04). Conclusion: We have found a different frequency of deficit for fat-soluble vitamin both in BPD and RYGB once we have adjusted for its main carriers. This is clinically relevant to prevent from overexposure and toxicity. We suggest that carrier molecules should be routinely requested when we assess fat-soluble vitamin status in patients who undergo malabsorptive procedures.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014000800015&lng=en&tlng=enCirugía bariátricaVitaminaLiposolubleDerivación biliopancreáticaDerivación gástrica en Y de Roux |
| spellingShingle | Martín Cuesta Laura Pelaz Celia Pérez M.ª José Torrejón Lucio Cabrerizo Pilar Matía Natalia Pérez-Ferre Andrés Sánchez-Pernaute Antonio Torres Miguel A. Rubio Fat-soluble vitamin deficiencies after bariatric surgery could be misleading if they are not appropriately adjusted Nutrición Hospitalaria Cirugía bariátrica Vitamina Liposoluble Derivación biliopancreática Derivación gástrica en Y de Roux |
| title | Fat-soluble vitamin deficiencies after bariatric surgery could be misleading if they are not appropriately adjusted |
| title_full | Fat-soluble vitamin deficiencies after bariatric surgery could be misleading if they are not appropriately adjusted |
| title_fullStr | Fat-soluble vitamin deficiencies after bariatric surgery could be misleading if they are not appropriately adjusted |
| title_full_unstemmed | Fat-soluble vitamin deficiencies after bariatric surgery could be misleading if they are not appropriately adjusted |
| title_short | Fat-soluble vitamin deficiencies after bariatric surgery could be misleading if they are not appropriately adjusted |
| title_sort | fat soluble vitamin deficiencies after bariatric surgery could be misleading if they are not appropriately adjusted |
| topic | Cirugía bariátrica Vitamina Liposoluble Derivación biliopancreática Derivación gástrica en Y de Roux |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112014000800015&lng=en&tlng=en |
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