Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes

Amygdala 5-HTT Gene Network Moderates the Effects of Postnatal Adversity on Attention Problems: Anatomo-Functional Correlation and Epigenetic Changes

Variations in serotoninergic signaling have been related to behavioral outcomes. Alterations in the genome, such as DNA methylation and histone modifications, are affected by serotonin neurotransmission. The amygdala is an important brain region involved in emotional responses and impulsivity, which...

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Bibliographic Details
Main Authors: Randriely Merscher Sobreira de Lima, Barbara Barth, Danusa Mar Arcego, Euclides José de Mendonça Filho, Andrew Clappison, Sachin Patel, Zihan Wang, Irina Pokhvisneva, Roberto Britto Sassi, Geoffrey B. C. Hall, Michael S. Kobor, Kieran J. O'Donnell, Ana Paula Santana de Vasconcellos Bittencourt, Michael J. Meaney, Carla Dalmaz, Patrícia Pelufo Silveira
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Neuroscience
Subjects:
early environment
serotonin transporter
ADHD
DNA methylation
ePRS
parallel independent component analysis
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00198/full

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