Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish (<i>Danio rerio</i>)

Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish (<i>Danio rerio</i>)

The mechanisms of resistance to antidepressant drugs is a key and still unresolved problem of psychopharmacology. Serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) play a key role in the therapeutic effect of many antidepressants. Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzy...

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Bibliographic Details
Main Authors: Valentina S. Evsiukova, Daria Bazovkina, Ekaterina Bazhenova, Elizabeth A. Kulikova, Alexander V. Kulikov
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
tryptophan hydroxylase 2
serotonin
BDNF
brain
behavior
antidepressant resistance
Online Access:https://www.mdpi.com/1422-0067/22/23/12851

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