Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve Regeneration
This study focused on a potential application of electrically conductive, biocompatible, bioresorbable fibers for tubular conduits aimed at the regeneration of peripheral nerves. The conducting, mechanical, and biological properties of composite fibers based on chitosan and single-walled carbon nano...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/13/2860 |
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| author | Elena N. Dresvyanina Nurjemal A. Tagandurdyyeva Vera V. Kodolova-Chukhontseva Irina P. Dobrovol’skaya Almaz M. Kamalov Yulia A. Nashchekina Alexey V. Nashchekin Alexey G. Ivanov Galina Yu. Yukina Vladimir E. Yudin |
| author_facet | Elena N. Dresvyanina Nurjemal A. Tagandurdyyeva Vera V. Kodolova-Chukhontseva Irina P. Dobrovol’skaya Almaz M. Kamalov Yulia A. Nashchekina Alexey V. Nashchekin Alexey G. Ivanov Galina Yu. Yukina Vladimir E. Yudin |
| author_sort | Elena N. Dresvyanina |
| collection | DOAJ |
| description | This study focused on a potential application of electrically conductive, biocompatible, bioresorbable fibers for tubular conduits aimed at the regeneration of peripheral nerves. The conducting, mechanical, and biological properties of composite fibers based on chitosan and single-walled carbon nanotubes were investigated in this paper. It was shown that introducing 0.5 wt.% of SWCNT into the composite fibers facilitated the formation of a denser fiber structure, resulting in improved strength (σ = 260 MPa) and elastic (E = 14 GPa) characteristics. Additionally, the composite fibers were found to be biocompatible and did not cause significant inflammation or deformation during in vivo studies. A thin layer of connective tissue formed around the fiber. |
| first_indexed | 2024-03-11T01:31:12Z |
| format | Article |
| id | doaj.art-4b9b5c476f4b4bc595978ce6fefdb1a3 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T01:31:12Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-4b9b5c476f4b4bc595978ce6fefdb1a32023-11-18T17:21:12ZengMDPI AGPolymers2073-43602023-06-011513286010.3390/polym15132860Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve RegenerationElena N. Dresvyanina0Nurjemal A. Tagandurdyyeva1Vera V. Kodolova-Chukhontseva2Irina P. Dobrovol’skaya3Almaz M. Kamalov4Yulia A. Nashchekina5Alexey V. Nashchekin6Alexey G. Ivanov7Galina Yu. Yukina8Vladimir E. Yudin9Institute of Textile and Fashion, Saint Petersburg State University of Industrial Technologies and Design, B. Morskaya Str., 18, Saint Petersburg 191186, RussiaInstitute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, Polytekhnicheskaya Str., 29, Saint Petersburg 195251, RussiaInstitute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, Polytekhnicheskaya Str., 29, Saint Petersburg 195251, RussiaInstitute of Macromolecular Compounds of Russian Academy of Sciences, VO Bolshoy pr., 31, Saint Petersburg 199004, RussiaInstitute of Biomedical Systems and Biotechnology, Peter the Great Saint Petersburg Polytechnic University, Polytekhnicheskaya Str., 29, Saint Petersburg 195251, RussiaInstitute of Cytology Russian Academy of Sciences, Tikhoretsky Ave., 4, Saint Petersburg 194064, RussiaIoffe Institute, Polytekhnicheskaya Str., 26, Saint Petersburg 194021, RussiaInstitute of Macromolecular Compounds of Russian Academy of Sciences, VO Bolshoy pr., 31, Saint Petersburg 199004, RussiaPavlov First Saint Petersburg State Medical University, L’va Tolstogo Str. 6-8, Saint Petersburg 197022, RussiaInstitute of Macromolecular Compounds of Russian Academy of Sciences, VO Bolshoy pr., 31, Saint Petersburg 199004, RussiaThis study focused on a potential application of electrically conductive, biocompatible, bioresorbable fibers for tubular conduits aimed at the regeneration of peripheral nerves. The conducting, mechanical, and biological properties of composite fibers based on chitosan and single-walled carbon nanotubes were investigated in this paper. It was shown that introducing 0.5 wt.% of SWCNT into the composite fibers facilitated the formation of a denser fiber structure, resulting in improved strength (σ = 260 MPa) and elastic (E = 14 GPa) characteristics. Additionally, the composite fibers were found to be biocompatible and did not cause significant inflammation or deformation during in vivo studies. A thin layer of connective tissue formed around the fiber.https://www.mdpi.com/2073-4360/15/13/2860chitosanwet spinningsingle-wall carbon nanotubescompositesperipheral nerve regeneration |
| spellingShingle | Elena N. Dresvyanina Nurjemal A. Tagandurdyyeva Vera V. Kodolova-Chukhontseva Irina P. Dobrovol’skaya Almaz M. Kamalov Yulia A. Nashchekina Alexey V. Nashchekin Alexey G. Ivanov Galina Yu. Yukina Vladimir E. Yudin Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve Regeneration Polymers chitosan wet spinning single-wall carbon nanotubes composites peripheral nerve regeneration |
| title | Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve Regeneration |
| title_full | Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve Regeneration |
| title_fullStr | Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve Regeneration |
| title_full_unstemmed | Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve Regeneration |
| title_short | Structure and Properties of Composite Fibers Based on Chitosan and Single-Walled Carbon Nanotubes for Peripheral Nerve Regeneration |
| title_sort | structure and properties of composite fibers based on chitosan and single walled carbon nanotubes for peripheral nerve regeneration |
| topic | chitosan wet spinning single-wall carbon nanotubes composites peripheral nerve regeneration |
| url | https://www.mdpi.com/2073-4360/15/13/2860 |
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