The Outcomes of Primary Debulking Surgery and Neoadjuvant Chemotherapy in Advanced Ovarian Cancer
Objective: To compare the outcomes and survival rate of primary debulking surgery with neoadjuvant chemotherapy. Method: We selected advanced ovarian cancer patients from medical records. Subjects were allocated into groups of primary debulking surgery and neoajuvant chemotherapy by considering...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Indonesian Society of Obstetrics and Gynecology
2016-04-01
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| Series: | Indonesian Journal of Obstetrics and Gynecology |
| Online Access: | http://inajog.com/index.php/journal/article/view/86 |
| Summary: | Objective: To compare the outcomes and survival rate of primary
debulking surgery with neoadjuvant chemotherapy.
Method: We selected advanced ovarian cancer patients from medical
records. Subjects were allocated into groups of primary debulking
surgery and neoajuvant chemotherapy by considering the inclusion
and exclusion criteria. We analyzed the data using T test,
Fisher’s exact, and chi-square. The survival rate was presented in
Kaplan Meier curve, whereas the significance was tested with Logrank.
We managed the data using STRATA software version 12.
Result: We obtained 32 cases of primary debulking surgery group
and 20 cases of the neoadjuvant chemotherapy group. Most of the
subjects (44.2%) were 40-49 years old and 80.8% had delivered
more than twice. The mean value of Ca-125 at admission was
3,594.8 u/ml (range 66.6 to 73,000 u/ml). Total of 31 subjects
showed the serous histologic type (59.6%). There was no association
between primary debulking surgery and neoadjuvant chemotherapy
for the parameter of operative time, blood loss, organs injury,
ICU stay, and hospital stay (p>0.05). Primary debulking surgery
had a survival rate similar to neoadjuvant chemotherapy group
(p=0.95).
Conclusion: The perioperative outcomes of advanced ovarian cancer
patients has similar result between primary debulking surgery
and neoadjuvant chemotherapy. Primary debulking surgery has a
survival rate similar to neoadjuvant chemotherapy group.
[Indones J Obstet Gynecol 2016; 4-2: 111-115]
Keywords: advanced ovarian cancer, neoadjuvant chemotherapy,
primary debulking surgery |
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| ISSN: | 2338-6401 2338-7335 |