Relationship between Aldose reductase and superoxide dismutase inhibition capacities of indole-based analogs of melatonin derivatives
Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Under diabetic conditions, the elevated vascular glucose level causes an increased flux through the polyol pathway, which induces functional and morphological changes associated with secondary diabetic complications...
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2009-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2009/0354-46640904675D.pdf |
| _version_ | 1818050880964919296 |
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| author | Daş-Evcimen N. Yildirim Ö. Suzen S. |
| author_facet | Daş-Evcimen N. Yildirim Ö. Suzen S. |
| author_sort | Daş-Evcimen N. |
| collection | DOAJ |
| description | Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Under diabetic conditions, the elevated vascular glucose level causes an increased flux through the polyol pathway, which induces functional and morphological changes associated with secondary diabetic complications such as cataract, neuropathy, and nephropathy. Oxidative stress, antioxidants, and the polyol pathway have recently been found to be linked in pathological states. A large number of structurally different compounds have been studied as potent in vitro AR inhibitors (ARIs). However, with few exceptions, these compounds did not show clinical benefit, and some even produced serious side effects. In view of the ARI activity of certain indole derivative compounds and antioxidant properties of melatonin, we investigated some indole-based analogs of melatonin derivatives. Antioxidant and ARI activity tests were applied to nine indole derivatives that are substituted at the third and fifth positions. Also, the relationship between ARI and antioxidant enzyme activity is discussed. |
| first_indexed | 2024-12-10T11:00:31Z |
| format | Article |
| id | doaj.art-4ba30c7b93df4ea9ba523f9f1c94f6d3 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 |
| language | English |
| last_indexed | 2024-12-10T11:00:31Z |
| publishDate | 2009-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-4ba30c7b93df4ea9ba523f9f1c94f6d32022-12-22T01:51:43ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642009-01-0161467568110.2298/ABS0904675DRelationship between Aldose reductase and superoxide dismutase inhibition capacities of indole-based analogs of melatonin derivativesDaş-Evcimen N.Yildirim Ö.Suzen S.Aldose reductase (AR) has been implicated in the etiology of diabetic complications. Under diabetic conditions, the elevated vascular glucose level causes an increased flux through the polyol pathway, which induces functional and morphological changes associated with secondary diabetic complications such as cataract, neuropathy, and nephropathy. Oxidative stress, antioxidants, and the polyol pathway have recently been found to be linked in pathological states. A large number of structurally different compounds have been studied as potent in vitro AR inhibitors (ARIs). However, with few exceptions, these compounds did not show clinical benefit, and some even produced serious side effects. In view of the ARI activity of certain indole derivative compounds and antioxidant properties of melatonin, we investigated some indole-based analogs of melatonin derivatives. Antioxidant and ARI activity tests were applied to nine indole derivatives that are substituted at the third and fifth positions. Also, the relationship between ARI and antioxidant enzyme activity is discussed.http://www.doiserbia.nb.rs/img/doi/0354-4664/2009/0354-46640904675D.pdfAldose reductaseantioxidantdiabetes mellitusindolemelatonin |
| spellingShingle | Daş-Evcimen N. Yildirim Ö. Suzen S. Relationship between Aldose reductase and superoxide dismutase inhibition capacities of indole-based analogs of melatonin derivatives Archives of Biological Sciences Aldose reductase antioxidant diabetes mellitus indole melatonin |
| title | Relationship between Aldose reductase and superoxide dismutase inhibition capacities of indole-based analogs of melatonin derivatives |
| title_full | Relationship between Aldose reductase and superoxide dismutase inhibition capacities of indole-based analogs of melatonin derivatives |
| title_fullStr | Relationship between Aldose reductase and superoxide dismutase inhibition capacities of indole-based analogs of melatonin derivatives |
| title_full_unstemmed | Relationship between Aldose reductase and superoxide dismutase inhibition capacities of indole-based analogs of melatonin derivatives |
| title_short | Relationship between Aldose reductase and superoxide dismutase inhibition capacities of indole-based analogs of melatonin derivatives |
| title_sort | relationship between aldose reductase and superoxide dismutase inhibition capacities of indole based analogs of melatonin derivatives |
| topic | Aldose reductase antioxidant diabetes mellitus indole melatonin |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2009/0354-46640904675D.pdf |
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