Adverse drug reactions in drug information databases: does presentation affect interpretation?
Objective: Formatting of adverse drug reaction (ADR) information differs among drug information (DI) resources and may impact clinical decision-making. The objective of this study was to determine whether ADR formatting impacts adverse event interpretation by pharmacy practitioners and students. Met...
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| Format: | Article |
| Language: | English |
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University Library System, University of Pittsburgh
2020-01-01
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| Series: | Journal of the Medical Library Association |
| Subjects: | |
| Online Access: | http://jmla.pitt.edu/ojs/jmla/article/view/748 |
| _version_ | 1819032044260294656 |
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| author | Sean M. McConachie Christopher A. Giuliano Insaf Mohammad Pramodini B. Kale-Pradhan |
| author_facet | Sean M. McConachie Christopher A. Giuliano Insaf Mohammad Pramodini B. Kale-Pradhan |
| author_sort | Sean M. McConachie |
| collection | DOAJ |
| description | Objective: Formatting of adverse drug reaction (ADR) information differs among drug information (DI) resources and may impact clinical decision-making. The objective of this study was to determine whether ADR formatting impacts adverse event interpretation by pharmacy practitioners and students.
Methods: Participants were randomized to receive ADR information in a comparative quantitative (CQUANT), noncomparative quantitative (NQUANT), or noncomparative qualitative (NQUAL) format to interpret 3 clinical vignettes. Vignettes involved patients presenting with adverse events that varied in the extent to which they were associated with a medication. The primary outcome was interpretation of the likelihood of medication-induced adverse events on a 10-point Likert scale. Lower scoring on likelihood (i.e., ADR deemed unlikely) reflected more appropriate interpretation. Linear regression was performed to analyze the effects of ADR information format on the primary outcome.
Results: A total of 108 participants completed the study (39 students and 69 pharmacists). Overall, the CQUANT group had the lowest average likelihood compared to NQUAL (4.0 versus 5.4; p<0.01) and NQUANT (4.0 versus 4.9; p=0.016) groups. There was no difference between NQUAL and NQUANT groups (5.4 versus 4.9; p=0.14). In the final model, at least 2 years of postgraduate training (–1.1; 95% CI: –1.8 to –0.3; p<0.01) and CQUANT formatting (–1.3; 95% CI: –0.9 to –1.7; p<0.01) were associated with reduced likelihood.
Conclusions: Formatting impacts pharmacists’ and pharmacy students’ interpretation of ADR information. CQUANT formatting and at least two years of postgraduate training improved interpretation of adverse events. |
| first_indexed | 2024-12-21T06:55:41Z |
| format | Article |
| id | doaj.art-4ba3982c9d6c4b6299c1d3070f5a51e5 |
| institution | Directory Open Access Journal |
| issn | 1536-5050 1558-9439 |
| language | English |
| last_indexed | 2024-12-21T06:55:41Z |
| publishDate | 2020-01-01 |
| publisher | University Library System, University of Pittsburgh |
| record_format | Article |
| series | Journal of the Medical Library Association |
| spelling | doaj.art-4ba3982c9d6c4b6299c1d3070f5a51e52022-12-21T19:12:20ZengUniversity Library System, University of PittsburghJournal of the Medical Library Association1536-50501558-94392020-01-01108110.5195/jmla.2020.748429Adverse drug reactions in drug information databases: does presentation affect interpretation?Sean M. McConachie0Christopher A. Giuliano1Insaf Mohammad2Pramodini B. Kale-Pradhan3Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, and, Beaumont Hospital, Dearborn, MIEugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, and and, Ascension St. John Hospital, Dearborn, MIEugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, and and, Beaumont Hospital, Dearborn, MIEugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, and and, Ascension St. John Hospital, Dearborn, MIObjective: Formatting of adverse drug reaction (ADR) information differs among drug information (DI) resources and may impact clinical decision-making. The objective of this study was to determine whether ADR formatting impacts adverse event interpretation by pharmacy practitioners and students. Methods: Participants were randomized to receive ADR information in a comparative quantitative (CQUANT), noncomparative quantitative (NQUANT), or noncomparative qualitative (NQUAL) format to interpret 3 clinical vignettes. Vignettes involved patients presenting with adverse events that varied in the extent to which they were associated with a medication. The primary outcome was interpretation of the likelihood of medication-induced adverse events on a 10-point Likert scale. Lower scoring on likelihood (i.e., ADR deemed unlikely) reflected more appropriate interpretation. Linear regression was performed to analyze the effects of ADR information format on the primary outcome. Results: A total of 108 participants completed the study (39 students and 69 pharmacists). Overall, the CQUANT group had the lowest average likelihood compared to NQUAL (4.0 versus 5.4; p<0.01) and NQUANT (4.0 versus 4.9; p=0.016) groups. There was no difference between NQUAL and NQUANT groups (5.4 versus 4.9; p=0.14). In the final model, at least 2 years of postgraduate training (–1.1; 95% CI: –1.8 to –0.3; p<0.01) and CQUANT formatting (–1.3; 95% CI: –0.9 to –1.7; p<0.01) were associated with reduced likelihood. Conclusions: Formatting impacts pharmacists’ and pharmacy students’ interpretation of ADR information. CQUANT formatting and at least two years of postgraduate training improved interpretation of adverse events.http://jmla.pitt.edu/ojs/jmla/article/view/748adverse drug reactionclinical pharmacy information systemsdrug information service |
| spellingShingle | Sean M. McConachie Christopher A. Giuliano Insaf Mohammad Pramodini B. Kale-Pradhan Adverse drug reactions in drug information databases: does presentation affect interpretation? Journal of the Medical Library Association adverse drug reaction clinical pharmacy information systems drug information service |
| title | Adverse drug reactions in drug information databases: does presentation affect interpretation? |
| title_full | Adverse drug reactions in drug information databases: does presentation affect interpretation? |
| title_fullStr | Adverse drug reactions in drug information databases: does presentation affect interpretation? |
| title_full_unstemmed | Adverse drug reactions in drug information databases: does presentation affect interpretation? |
| title_short | Adverse drug reactions in drug information databases: does presentation affect interpretation? |
| title_sort | adverse drug reactions in drug information databases does presentation affect interpretation |
| topic | adverse drug reaction clinical pharmacy information systems drug information service |
| url | http://jmla.pitt.edu/ojs/jmla/article/view/748 |
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