Sebo-pharmacokinetics: a proposed percutaneous sebum egression method
Background/Aims: The sebaceous gland is widely believed a critical factor in the pathogenesis of acne vulgaris. Although extensive studies document the ability of oral and topical treatments to improve acne, little is known about the quantification and mechanism of drug delivery via the sebaceous gl...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2019-02-01
|
| Series: | Journal of Dermatological Treatment |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09546634.2018.1476648 |
| _version_ | 1797683734948872192 |
|---|---|
| author | Rasika Reddy John Havens Cary Akram Elmahdy Howard Maibach |
| author_facet | Rasika Reddy John Havens Cary Akram Elmahdy Howard Maibach |
| author_sort | Rasika Reddy |
| collection | DOAJ |
| description | Background/Aims: The sebaceous gland is widely believed a critical factor in the pathogenesis of acne vulgaris. Although extensive studies document the ability of oral and topical treatments to improve acne, little is known about the quantification and mechanism of drug delivery via the sebaceous gland. A percutaneous egression method presents a way to study how drugs reaching the bloodstream can enter the skin. Methods: A literature search was performed across databases (PubMed, Embase, and Google Scholar) and the University of California, San Francisco (UCSF) textbook library with relevant search terms. Results: This search failed to reveal data on sebo-pharmacokinetics (PK); however, many articles center on pharmacodynamics (PD) – i.e. functional improvement instigated by oral or topical treatments. Experiments on humans and hamsters – representative sebaceous gland models – demonstrate indirect PD measures of sebaceous gland function. Discussion: Here, we summarize the current available data on drug delivery via the sebaceous gland and suggest a practical method to directly document sebo-PK in man and animal. |
| first_indexed | 2024-03-12T00:19:04Z |
| format | Article |
| id | doaj.art-4ba4bd61248848309ed2f03077ece72a |
| institution | Directory Open Access Journal |
| issn | 0954-6634 1471-1753 |
| language | English |
| last_indexed | 2024-03-12T00:19:04Z |
| publishDate | 2019-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj.art-4ba4bd61248848309ed2f03077ece72a2023-09-15T14:08:32ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532019-02-0130218919310.1080/09546634.2018.14766481476648Sebo-pharmacokinetics: a proposed percutaneous sebum egression methodRasika Reddy0John Havens Cary1Akram Elmahdy2Howard Maibach3Veterans Affairs Medical CenterUniversity of CaliforniaUniversity of CaliforniaUniversity of CaliforniaBackground/Aims: The sebaceous gland is widely believed a critical factor in the pathogenesis of acne vulgaris. Although extensive studies document the ability of oral and topical treatments to improve acne, little is known about the quantification and mechanism of drug delivery via the sebaceous gland. A percutaneous egression method presents a way to study how drugs reaching the bloodstream can enter the skin. Methods: A literature search was performed across databases (PubMed, Embase, and Google Scholar) and the University of California, San Francisco (UCSF) textbook library with relevant search terms. Results: This search failed to reveal data on sebo-pharmacokinetics (PK); however, many articles center on pharmacodynamics (PD) – i.e. functional improvement instigated by oral or topical treatments. Experiments on humans and hamsters – representative sebaceous gland models – demonstrate indirect PD measures of sebaceous gland function. Discussion: Here, we summarize the current available data on drug delivery via the sebaceous gland and suggest a practical method to directly document sebo-PK in man and animal.http://dx.doi.org/10.1080/09546634.2018.1476648sebumsebaceous glanddrug deliveryisotretinoinpharmacokineticsacne vulgaris |
| spellingShingle | Rasika Reddy John Havens Cary Akram Elmahdy Howard Maibach Sebo-pharmacokinetics: a proposed percutaneous sebum egression method Journal of Dermatological Treatment sebum sebaceous gland drug delivery isotretinoin pharmacokinetics acne vulgaris |
| title | Sebo-pharmacokinetics: a proposed percutaneous sebum egression method |
| title_full | Sebo-pharmacokinetics: a proposed percutaneous sebum egression method |
| title_fullStr | Sebo-pharmacokinetics: a proposed percutaneous sebum egression method |
| title_full_unstemmed | Sebo-pharmacokinetics: a proposed percutaneous sebum egression method |
| title_short | Sebo-pharmacokinetics: a proposed percutaneous sebum egression method |
| title_sort | sebo pharmacokinetics a proposed percutaneous sebum egression method |
| topic | sebum sebaceous gland drug delivery isotretinoin pharmacokinetics acne vulgaris |
| url | http://dx.doi.org/10.1080/09546634.2018.1476648 |
| work_keys_str_mv | AT rasikareddy sebopharmacokineticsaproposedpercutaneoussebumegressionmethod AT johnhavenscary sebopharmacokineticsaproposedpercutaneoussebumegressionmethod AT akramelmahdy sebopharmacokineticsaproposedpercutaneoussebumegressionmethod AT howardmaibach sebopharmacokineticsaproposedpercutaneoussebumegressionmethod |