Cyanoacrylate in Colorectal Surgery: Is It Safe?
Anastomotic leakage (AL) of a gastrointestinal (GI) anastomosis continues to be an important complication in GI surgery. Since its introduction more than 60 years ago, Cyanoacrylate (CA) has gained popularity in colorectal surgery to provide “prophylaxis” against AL. However, although in surgical pr...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/15/5152 |
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| author | Anna D’Amore Pietro Anoldo Michele Manigrasso Giovanni Aprea Giovanni Domenico De Palma Marco Milone |
| author_facet | Anna D’Amore Pietro Anoldo Michele Manigrasso Giovanni Aprea Giovanni Domenico De Palma Marco Milone |
| author_sort | Anna D’Amore |
| collection | DOAJ |
| description | Anastomotic leakage (AL) of a gastrointestinal (GI) anastomosis continues to be an important complication in GI surgery. Since its introduction more than 60 years ago, Cyanoacrylate (CA) has gained popularity in colorectal surgery to provide “prophylaxis” against AL. However, although in surgical practice it is increasingly used, evidence on humans is still lacking. The aim of this study is to analyze in humans the safety of CA to seal colorectal anastomosis. All consecutive patients from Jannuary 2022 through December 2022 who underwent minimally invasive colorectal surgery were retrospectively analyzed from a prospectively maintained database. Inclusion criteria were a histological diagnosis of cancer, a totally minimally invasive procedure, and the absence of intraoperative complications. 103 patients were included in the study; N-butyl cyanoacrylate with metacryloxisulfolane (Glubran 2<sup>®</sup>) was used to seal colorectal anastomosis, no adverse reactions to CA or postoperative complications related to inflammation and adhesions occurred; and only one case of AL (0.9%) was recorded. We can consider this study an important proof of concept on the safety of CA to seal colorectal anastomosis. It opens the possibility of starting prospective and comparative studies in humans to evaluate the effectiveness of CA in preventing colorectal AL. |
| first_indexed | 2024-03-11T00:23:18Z |
| format | Article |
| id | doaj.art-4ba4c16ba4104c16a34824e540817c02 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T00:23:18Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4ba4c16ba4104c16a34824e540817c022023-11-18T23:10:04ZengMDPI AGJournal of Clinical Medicine2077-03832023-08-011215515210.3390/jcm12155152Cyanoacrylate in Colorectal Surgery: Is It Safe?Anna D’Amore0Pietro Anoldo1Michele Manigrasso2Giovanni Aprea3Giovanni Domenico De Palma4Marco Milone5Department of Clinical Medicine and Surgery, “Federico II” University of Naples, 80131 Naples, ItalyDepartment of Advanced Biomedical Sciences, “Federico II” University of Naples, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, “Federico II” University of Naples, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, “Federico II” University of Naples, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, “Federico II” University of Naples, 80131 Naples, ItalyDepartment of Clinical Medicine and Surgery, “Federico II” University of Naples, 80131 Naples, ItalyAnastomotic leakage (AL) of a gastrointestinal (GI) anastomosis continues to be an important complication in GI surgery. Since its introduction more than 60 years ago, Cyanoacrylate (CA) has gained popularity in colorectal surgery to provide “prophylaxis” against AL. However, although in surgical practice it is increasingly used, evidence on humans is still lacking. The aim of this study is to analyze in humans the safety of CA to seal colorectal anastomosis. All consecutive patients from Jannuary 2022 through December 2022 who underwent minimally invasive colorectal surgery were retrospectively analyzed from a prospectively maintained database. Inclusion criteria were a histological diagnosis of cancer, a totally minimally invasive procedure, and the absence of intraoperative complications. 103 patients were included in the study; N-butyl cyanoacrylate with metacryloxisulfolane (Glubran 2<sup>®</sup>) was used to seal colorectal anastomosis, no adverse reactions to CA or postoperative complications related to inflammation and adhesions occurred; and only one case of AL (0.9%) was recorded. We can consider this study an important proof of concept on the safety of CA to seal colorectal anastomosis. It opens the possibility of starting prospective and comparative studies in humans to evaluate the effectiveness of CA in preventing colorectal AL.https://www.mdpi.com/2077-0383/12/15/5152cyanoacrylatecolorectal surgeryminimally invasive surgeryanastomosisleakageinflammation |
| spellingShingle | Anna D’Amore Pietro Anoldo Michele Manigrasso Giovanni Aprea Giovanni Domenico De Palma Marco Milone Cyanoacrylate in Colorectal Surgery: Is It Safe? Journal of Clinical Medicine cyanoacrylate colorectal surgery minimally invasive surgery anastomosis leakage inflammation |
| title | Cyanoacrylate in Colorectal Surgery: Is It Safe? |
| title_full | Cyanoacrylate in Colorectal Surgery: Is It Safe? |
| title_fullStr | Cyanoacrylate in Colorectal Surgery: Is It Safe? |
| title_full_unstemmed | Cyanoacrylate in Colorectal Surgery: Is It Safe? |
| title_short | Cyanoacrylate in Colorectal Surgery: Is It Safe? |
| title_sort | cyanoacrylate in colorectal surgery is it safe |
| topic | cyanoacrylate colorectal surgery minimally invasive surgery anastomosis leakage inflammation |
| url | https://www.mdpi.com/2077-0383/12/15/5152 |
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