Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time
Stem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). We have shown previously that endogenous stem cell potential is confined to ependymal cells in the adult spinal cord which could be targeted for non-invasive SCI therapy. However, ependymal cells are an under...
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Elsevier
2016-11-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396416304960 |
| _version_ | 1818137328014589952 |
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| author | Xiaofei Li Elisa M. Floriddia Konstantinos Toskas Karl J.L. Fernandes Nicolas Guérout Fanie Barnabé-Heider |
| author_facet | Xiaofei Li Elisa M. Floriddia Konstantinos Toskas Karl J.L. Fernandes Nicolas Guérout Fanie Barnabé-Heider |
| author_sort | Xiaofei Li |
| collection | DOAJ |
| description | Stem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). We have shown previously that endogenous stem cell potential is confined to ependymal cells in the adult spinal cord which could be targeted for non-invasive SCI therapy. However, ependymal cells are an understudied cell population. Taking advantage of transgenic lines, we characterize the appearance and potential of ependymal cells during development. We show that spinal cord stem cell potential in vitro is contained within these cells by birth. Moreover, juvenile cultures generate more neurospheres and more oligodendrocytes than adult ones. Interestingly, juvenile ependymal cells in vivo contribute to glial scar formation after severe but not mild SCI, due to a more effective sealing of the lesion by other glial cells. This study highlights the importance of the age-dependent potential of stem cells and post-SCI environment in order to utilize ependymal cell's regenerative potential. |
| first_indexed | 2024-12-11T09:54:33Z |
| format | Article |
| id | doaj.art-4ba4de3471864dfa8201dcef2e9d846a |
| institution | Directory Open Access Journal |
| issn | 2352-3964 |
| language | English |
| last_indexed | 2024-12-11T09:54:33Z |
| publishDate | 2016-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj.art-4ba4de3471864dfa8201dcef2e9d846a2022-12-22T01:12:18ZengElsevierEBioMedicine2352-39642016-11-0113C556510.1016/j.ebiom.2016.10.035Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over TimeXiaofei Li0Elisa M. Floriddia1Konstantinos Toskas2Karl J.L. Fernandes3Nicolas Guérout4Fanie Barnabé-Heider5Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, SwedenDepartment of Neuroscience, Karolinska Institutet, 171 77 Stockholm, SwedenDepartment of Neuroscience, Karolinska Institutet, 171 77 Stockholm, SwedenDepartment of Neurosciences, Research Center of the University of Montreal Hospital (CRCHUM), QC H2X 0A9 Montreal, CanadaDepartment of Neuroscience, Karolinska Institutet, 171 77 Stockholm, SwedenDepartment of Neuroscience, Karolinska Institutet, 171 77 Stockholm, SwedenStem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). We have shown previously that endogenous stem cell potential is confined to ependymal cells in the adult spinal cord which could be targeted for non-invasive SCI therapy. However, ependymal cells are an understudied cell population. Taking advantage of transgenic lines, we characterize the appearance and potential of ependymal cells during development. We show that spinal cord stem cell potential in vitro is contained within these cells by birth. Moreover, juvenile cultures generate more neurospheres and more oligodendrocytes than adult ones. Interestingly, juvenile ependymal cells in vivo contribute to glial scar formation after severe but not mild SCI, due to a more effective sealing of the lesion by other glial cells. This study highlights the importance of the age-dependent potential of stem cells and post-SCI environment in order to utilize ependymal cell's regenerative potential.http://www.sciencedirect.com/science/article/pii/S2352396416304960Spinal cord injuryStem cell potentialEpendymal cellsDevelopmentGlial cellsJuvenile |
| spellingShingle | Xiaofei Li Elisa M. Floriddia Konstantinos Toskas Karl J.L. Fernandes Nicolas Guérout Fanie Barnabé-Heider Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time EBioMedicine Spinal cord injury Stem cell potential Ependymal cells Development Glial cells Juvenile |
| title | Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time |
| title_full | Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time |
| title_fullStr | Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time |
| title_full_unstemmed | Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time |
| title_short | Regenerative Potential of Ependymal Cells for Spinal Cord Injuries Over Time |
| title_sort | regenerative potential of ependymal cells for spinal cord injuries over time |
| topic | Spinal cord injury Stem cell potential Ependymal cells Development Glial cells Juvenile |
| url | http://www.sciencedirect.com/science/article/pii/S2352396416304960 |
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