Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges
Abstract Cytokines are signaling molecules between cells in immune system. Cytokine storm, due to the sudden acute increase in levels of pro‐inflammatory circulating cytokines, can result in disease severity and major‐organ damage. Thus, there is urgent need to develop rapid, sensitive, and specific...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | View |
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| Online Access: | https://doi.org/10.1002/VIW.20210003 |
| _version_ | 1818391175172718592 |
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| author | Guozhen Liu Cheng Jiang Xiaoting Lin Yang Yang |
| author_facet | Guozhen Liu Cheng Jiang Xiaoting Lin Yang Yang |
| author_sort | Guozhen Liu |
| collection | DOAJ |
| description | Abstract Cytokines are signaling molecules between cells in immune system. Cytokine storm, due to the sudden acute increase in levels of pro‐inflammatory circulating cytokines, can result in disease severity and major‐organ damage. Thus, there is urgent need to develop rapid, sensitive, and specific methods for monitoring of cytokines in biology and medicine. Undoubtedly, point‐of‐care testing (POCT) will provide clinical significance in disease early diagnosis, management, and prevention. This review aims to summarize and discuss the latest technologies for detection of cytokines with a focus on POCT. The overview of diseases resulting from imbalanced cytokine levels, such as COVID‐19, sepsis and other cytokine release syndromes are presented. The clinical cut‐off levels of cytokine as biomarkers for different diseases are summarized. The challenges and perspectives on the development of cytokine POCT devices are also proposed and discussed. Cytokine POCT devices are expected to be the ongoing spotlight of disease management and prevention during COVID‐19 pandemic and also the post COVID‐19 pandemic era. |
| first_indexed | 2024-12-14T05:09:20Z |
| format | Article |
| id | doaj.art-4ba5b5999a4940e8af54f462fac032c5 |
| institution | Directory Open Access Journal |
| issn | 2688-3988 2688-268X |
| language | English |
| last_indexed | 2024-12-14T05:09:20Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | View |
| spelling | doaj.art-4ba5b5999a4940e8af54f462fac032c52022-12-21T23:16:00ZengWileyView2688-39882688-268X2021-08-0124n/an/a10.1002/VIW.20210003Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challengesGuozhen Liu0Cheng Jiang1Xiaoting Lin2Yang Yang3School of Life and Health Sciences The Chinese University of Hong Kong Shenzhen 518172 P.R. ChinaNuffield Department of Clinical Neurosciences John Radcliffe Hospital University of Oxford Oxford OX3 9DU United KingdomGraduate School of Biomedical Engineering University of New South Wales Sydney NSW 2052 AustraliaSchool of Life and Health Sciences The Chinese University of Hong Kong Shenzhen 518172 P.R. ChinaAbstract Cytokines are signaling molecules between cells in immune system. Cytokine storm, due to the sudden acute increase in levels of pro‐inflammatory circulating cytokines, can result in disease severity and major‐organ damage. Thus, there is urgent need to develop rapid, sensitive, and specific methods for monitoring of cytokines in biology and medicine. Undoubtedly, point‐of‐care testing (POCT) will provide clinical significance in disease early diagnosis, management, and prevention. This review aims to summarize and discuss the latest technologies for detection of cytokines with a focus on POCT. The overview of diseases resulting from imbalanced cytokine levels, such as COVID‐19, sepsis and other cytokine release syndromes are presented. The clinical cut‐off levels of cytokine as biomarkers for different diseases are summarized. The challenges and perspectives on the development of cytokine POCT devices are also proposed and discussed. Cytokine POCT devices are expected to be the ongoing spotlight of disease management and prevention during COVID‐19 pandemic and also the post COVID‐19 pandemic era.https://doi.org/10.1002/VIW.20210003COVID‐19cytokine biosensorscytokine stormdisposable sensorspoint‐of‐care diagnostics |
| spellingShingle | Guozhen Liu Cheng Jiang Xiaoting Lin Yang Yang Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges View COVID‐19 cytokine biosensors cytokine storm disposable sensors point‐of‐care diagnostics |
| title | Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges |
| title_full | Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges |
| title_fullStr | Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges |
| title_full_unstemmed | Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges |
| title_short | Point‐of‐care detection of cytokines in cytokine storm management and beyond: Significance and challenges |
| title_sort | point of care detection of cytokines in cytokine storm management and beyond significance and challenges |
| topic | COVID‐19 cytokine biosensors cytokine storm disposable sensors point‐of‐care diagnostics |
| url | https://doi.org/10.1002/VIW.20210003 |
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