Differential Susceptibility and Vulnerability of Brain Cells in C57BL/6 Mouse to Mitochondrial Dysfunction Induced by Short-Term Cuprizone Exposure

Differential Susceptibility and Vulnerability of Brain Cells in C57BL/6 Mouse to Mitochondrial Dysfunction Induced by Short-Term Cuprizone Exposure

Cuprizone (CPZ) is a chemical chelator toxic to mitochondria of cells. While inducing oligodendrocyte (OL) loss and demyelination, CPZ caused no fatal damage to the other brain cells (neurons, astrocytes, and microglia) in previous studies, suggesting differential susceptibility and vulnerability of...

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Bibliographic Details
Main Authors: Mengyi Luo, Maomao Deng, Zijia Yu, Yi Zhang, Shuqin Xu, Shengping Hu, Haiyun Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroanatomy
Subjects:
cuprizone
1H-MRS
mitochondrial dysfunction
susceptibility
vulnerability
brain cells
Online Access:https://www.frontiersin.org/article/10.3389/fnana.2020.00030/full

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